Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lilia M. Beauchamp"'
Autor:
Lilia M. Beauchamp, Takayuki Yamaji, James A. Fyfe, Raymond D. Price, Thomas A. Krenitsky, Anthony O. Caggiano, Nobuya Matsuoka
Publikováno v:
Drug Development Research. 62:49-59
The ability of endogenous neurotrophins, including nerve growth factor (NGF), to promote the survival and development of neurons provides convincing evidence for their therapeutic potential, despite significant barriers to their successful clinical u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b444c68755e2f02cfbf93a573ce30e8
https://doi.org/10.1002/ddr.10385
https://doi.org/10.1002/ddr.10385
Autor:
Karen K. Biron, Eric A. Meade, John E. Reardon, Wayne H. Miller, Lilia M. Beauchamp, Albert A. Smith, Charles A. Goss, Richard L. Miller
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:341-356
A racemic mixture of ganciclovir phosphonate was resolved by stereoselective phosphorylation using GMP kinase. The R-enantiomer of ganciclovir phosphonate was active against human cytomegalovirus but the S-enantiomer was less active. We show that ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a92a1dfc121d556957acf25d5856b
https://doi.org/10.1080/15257770008033013
https://doi.org/10.1080/15257770008033013
Autor:
Lilia M. Beauchamp, Howard J. Schaeffer, Gertrude B. Elion, Paulo de Miranda, James A. Fyfe, Phillip A. Furman
Publikováno v:
Reviews in Medical Virology. 9:147-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7921e4095107c207351bb24d4702065b
https://doi.org/10.1002/(sici)1099-1654(199907/09)9:3<147::aid-rmv255>3.0.co
https://doi.org/10.1002/(sici)1099-1654(199907/09)9:3<147::aid-rmv255>3.0.co
Publikováno v:
European Journal of Medicinal Chemistry. 33:363-374
An extensive series of analogues of the lead anxiolytic 4-benzylamino-2-methylpyrrolo[2,3-d]pyrimidine 1 was synthesized and evaluated in the Geller-Seifter conflict test for anxiolytic activity to discover a less toxic derivative. Analysis of the SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49de706e1e9d088d8ba480037366203
https://doi.org/10.1016/s0223-5234(98)80003-2
https://doi.org/10.1016/s0223-5234(98)80003-2
Publikováno v:
Journal of Heterocyclic Chemistry. 33:1605-1610
By modifying previously described methods for the synthesis of 9-substituted-guanines from imidazoles, we have developed a new procedure for the regioselective synthesis of 9-substituted-8-azaguanines (5-amino-3-substituted-3,6-dihydro-7H-1,2,3-triaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33ba10817ee40a989ad9d6f7fce852b
https://doi.org/10.1002/jhet.5570330609
https://doi.org/10.1002/jhet.5570330609
Publikováno v:
Nucleosides and Nucleotides. 15:1315-1321
The synthesis of a new ganciclovir analog with a trifluoromethyl group in the acyclic chain is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5833afb227163c7fd0bd026e7eca5ed5
https://doi.org/10.1080/07328319608002432
https://doi.org/10.1080/07328319608002432
Autor:
Eric A. Meade, Lilia M. Beauchamp
Publikováno v:
Journal of Heterocyclic Chemistry. 33:303-308
4-Benzylamino-6-methyl-1H-pyrrolo[3,2-c]pyridine (2) and 4-benzylamino-6-methyl-1H-pyrrolo[2,3-b]pyridine (3) were synthesized as deaza analogues of the anxiolytic agent 4-benzylamino-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (1). The 1-deaza analogue (2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b8872e50d8170cfd8223aa63904c37
https://doi.org/10.1002/jhet.5570330215
https://doi.org/10.1002/jhet.5570330215
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:565-568
From a group of pyrrolo[2,3- d ]pyrimidine compounds that have been screened against influenza virus, one derivative, 4-(3-piperidinyl benzylamino)-2-methyl-7 H -pyrrolo[2,3- d ]pyrimidine ( 9 ), has shown promising activity against both the A and B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a875a05a2ac4972e3eb10b544451515
https://doi.org/10.1016/0960-894x(96)00070-4
https://doi.org/10.1016/0960-894x(96)00070-4
Autor:
Martha Rodriguez, Taj Naseree, Tracy Scott, Roy Flanagan, Nabih Ghal, Barbara Johnston, Lilia M. Beauchamp
Publikováno v:
Nucleosides and Nucleotides. 14:1591-1600
A novel synthesis of 1-(β-D-pentopyranosyl)pyridinethione nucleosides utilizing pyridine-2(1H)-thiones and α-bromoxylose or β-bromoarabinose triacetate as starting components is described. The free nucleosides were tested for their potential activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7588cb4e795a041951f741a7c15d3e74
https://doi.org/10.1080/15257779508009494
https://doi.org/10.1080/15257779508009494
Autor:
G B Roberts, G. Darby, P de Miranda, S. Lacey, K. L. Powell, Lilia M. Beauchamp, S. G. Rahim, D. J. M. Purifoy, P. Ertl, Thomas A. Krenitsky
Publikováno v:
Journal of Medical Virology. 41:139-145
Research leading to the new anti-herpesvirus compounds discussed here has come from three approaches. The first approach was directed towards improving the bioavailability of acyclovir by examining the potential of a variety of prodrugs, leading to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2182cf99752b41dfd58afe84a982d75e
https://doi.org/10.1002/jmv.1890410527
https://doi.org/10.1002/jmv.1890410527