Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lilia Leisle"'
Autor:
Alexander K. Schuster, Lilia Leisle, Nils Picker, Hanne Bubendorfer-Vorwerk, Philip Lewis, Philipp Hahn, Jürgen Wasem, Robert P. Finger
Publikováno v:
Ophthalmology and Therapy, Vol 13, Iss 4, Pp 1025-1039 (2024)
Abstract Introduction Epidemiologic data on age-related macular degeneration (AMD) are mainly based on cohort studies, including both diagnosed and undiagnosed cases. Using health claims data allows estimating epidemiological data of diagnosed subjec
Externí odkaz:
https://doaj.org/article/ce784cea87024d5cbc8542cea2c4cf38
Autor:
Lilia Leisle, Kin Lam, Sepehr Dehghani-Ghahnaviyeh, Eva Fortea, Jason D. Galpin, Christopher A. Ahern, Emad Tajkhorshid, Alessio Accardi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
CLC-type channels selectively transport Cl− across biological membranes, but it is unclear how discrimination between anions is maintained. Here, authors use a combination of non-natural amino acid substitutions, electrophysiology, and molecular dy
Externí odkaz:
https://doaj.org/article/eabf06623768491494a18c38aba88802
Autor:
Lilia Leisle, Yanyan Xu, Eva Fortea, Sangyun Lee, Jason D Galpin, Malvin Vien, Christopher A Ahern, Alessio Accardi, Simon Bernèche
Publikováno v:
eLife, Vol 9 (2020)
The CLC family comprises H+-coupled exchangers and Cl- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through p
Externí odkaz:
https://doaj.org/article/c9ee0e91e4b94b3f972f512b0980c861
Autor:
Lilia Leisle, Rahul Chadda, John D Lueck, Daniel T Infield, Jason D Galpin, Venkatramanan Krishnamani, Janice L Robertson, Christopher A Ahern
Publikováno v:
eLife, Vol 5 (2016)
A general method is described for the site-specific genetic encoding of cyanine dyes as non-canonical amino acids (Cy-ncAAs) into proteins. The approach relies on an improved technique for nonsense suppression with in vitro misacylated orthogonal tRN
Externí odkaz:
https://doaj.org/article/217eeb09083548d5bba5fc63e7377a1b
Autor:
Lilia Leisle, Kin Lam, Sepehr Dehghani-Ghahnaviyeh, Eva Fortea, Jason Galpin, Christopher Ahern, Emad Tajkhorshid, Alessio Accardi
Chloride homeostasis is tightly regulated in cellular compartments by dedicated channels and transporters. Whereas CLC-type channels select for Cl− over other anions, all other ‘chloride’ channels are indiscriminate in their anionic permeabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0720d02a2b2586df02de1d45fb06953d
https://doi.org/10.21203/rs.3.rs-1813428/v1
https://doi.org/10.21203/rs.3.rs-1813428/v1
Autor:
Stefan Gründer, Elinor Cleuvers, Michèle Bachmann, Lilia Leisle, Michael A. Margreiter, Audrey Ortega-Ramírez, Giulia Rossetti
Publikováno v:
Journal of medicinal chemistry. 64(18)
Prolonged acidosis, as it occurs during ischemic stroke, induces neuronal death via acid-sensing ion channel 1a (ASIC1a). Concomitantly, it desensitizes ASIC1a, highlighting the pathophysiological significance of modulators of ASIC1a acid sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3fa8d1d70da35caf3448ceec80afa7
https://pubmed.ncbi.nlm.nih.gov/34461722
https://pubmed.ncbi.nlm.nih.gov/34461722
Publikováno v:
Channels
article-version (VoR) Version of Record
Channels 15(1), 273-283 (2021). doi:10.1080/19336950.2021.1882762
article-version (VoR) Version of Record
Channels 15(1), 273-283 (2021). doi:10.1080/19336950.2021.1882762
Channels 15(1), 273-283 (2021). doi:10.1080/19336950.2021.1882762
Published by Taylor & Francis, Abingdon, Oxon
Published by Taylor & Francis, Abingdon, Oxon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae66fd7e38ecbda1c1e618c5796d21ba
https://pubmed.ncbi.nlm.nih.gov/33522420
https://pubmed.ncbi.nlm.nih.gov/33522420
Autor:
Simon Bernèche, Eva Fortea, Sangyun Lee, Alessio Accardi, Jason D. Galpin, Malvin Vien, Lilia Leisle, Christopher A. Ahern, Yanyan Xu
Publikováno v:
eLife, Vol 9 (2020)
eLife 9, e51224 (2020). doi:10.7554/eLife.51224
eLife 9, e51224 (2020). doi:10.7554/eLife.51224
The CLC family comprises H; +; -coupled exchangers and Cl; -; channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45128363e1c120b641427ac12b07ed2
https://doi.org/10.7554/elife.51224
https://doi.org/10.7554/elife.51224
Publikováno v:
The Journal of General Physiology
A conserved glutamic acid residue is thought to occupy three different conformations in the transport pathway of CLC H+/Cl− exchangers. Vien et al. provide functional evidence that the most central of these three positions is adopted by CLC-ec1 dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1e020aa8fd39cc8110b1b6ba9c5022
https://doi.org/10.1085/jgp.201611682
https://doi.org/10.1085/jgp.201611682