Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lilia Fisk"'
Autor:
Donna S. Macmillan, Martyn L. Chilton, Lilia Fisk, Richard V. Williams, Alex Cayley, Mukesh Patel
Publikováno v:
Challenges and Advances in Computational Chemistry and Physics ISBN: 9783030164423
The correlation of chemical structure with physicochemical and biological data to assess a desired or undesired biological outcome now utilises both qualitative and quantitative structure–activity relationships ((Q)SARs) and advanced computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030251dbd686e6e89bb93d16e5bb549b
https://doi.org/10.1007/978-3-030-16443-0_3
https://doi.org/10.1007/978-3-030-16443-0_3
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493976768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe2501e57678c8a3865cfb6d5413274
https://doi.org/10.1007/978-1-4939-7677-5_4
https://doi.org/10.1007/978-1-4939-7677-5_4
Autor:
Lilia Fisk, Valerie J. Gillet, William C. Drewe, Mukesh Patel, Jonathan D. Vessey, Steven J. Canipa, Laurence Coquin, Richard Sherhod, Jeffrey Plante
Publikováno v:
Toxicology Research. 4:46-56
Emerging pattern mining techniques have been applied to datasets of Ames mutagens. The discovered patterns give rise to clusters of compounds from large and biased datasets which are used to develop new structural alerts for mutagenicity in the Derek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cebc49df912ce02f0bcbd51dac353a29
https://doi.org/10.1039/c4tx00071d
https://doi.org/10.1039/c4tx00071d
Publikováno v:
Chemistry & Biodiversity. 6:2107-2114
Hepatotoxicity is a major cause of pharmaceutical drug attrition and is also a concern within other chemical industries. In silico approaches to the prediction of hepatotoxicity are an important tool in the early identification of adverse effects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c095d3b538a11fad5dc0597c1542c50e
https://doi.org/10.1002/cbdv.200900133
https://doi.org/10.1002/cbdv.200900133
Publikováno v:
Neurochemical Research. 32:1741-1748
Pathogenesis of Alzheimer's disease (AD), which is characterised by accumulation of extracellular deposits of beta-amyloid peptide (Abeta) in the brain, has recently been linked to vascular disorders such as ischemia and stroke. Abeta is constantly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d387ef05842f0edc74f363571b9d4c
https://doi.org/10.1007/s11064-007-9349-2
https://doi.org/10.1007/s11064-007-9349-2
Publikováno v:
Annals of the New York Academy of Sciences. 1035:1-20
The levels of amyloid beta-peptides (Abeta) in the brain represent a dynamic equilibrium state as a result of their biosynthesis from the amyloid precursor protein (APP) by beta- and gamma-secretases, their degradation by a team of amyloid-degrading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ef89b4b98195a7b3f1578479901d6
https://doi.org/10.1196/annals.1332.001
https://doi.org/10.1196/annals.1332.001
Autor:
Svetlana A. Plesneva, Igor A. Zhuravin, Lilia Fisk, Rosa M. Canet. Aviles, Anthony J. Turner, Natalia N. Nalivaeva
Publikováno v:
Letters in Peptide Science. 10:455-462
In the present study we have investigated the effect of prenatal hypoxia on expression of amyloid precursor protein (APP) and some metallopeptidases, which regulate β-amyloid peptide (Aβ) levels (neprilysin (NEP) and endothelin-converting enzyme (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5284271653e23a01778fa6689f6164
https://doi.org/10.1007/bf02442577
https://doi.org/10.1007/bf02442577
Autor:
Nigel Greene, Lilia Fisk, Russell T. Naven, Reine R. Note, Mukesh L. Patel, Dennis J. Pelletier
Publikováno v:
Chemical research in toxicology. 23(7)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd76c6e90ffddf6cf46affcd7099bbf
https://pubmed.ncbi.nlm.nih.gov/20553011
https://pubmed.ncbi.nlm.nih.gov/20553011
Publikováno v:
ChemInform. 41
Hepatotoxicity is a major cause of pharmaceutical drug attrition and is also a concern within other chemical industries. In silico approaches to the prediction of hepatotoxicity are an important tool in the early identification of adverse effects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5591f150211d07f91aaeb7f5e9507c20
https://doi.org/10.1002/chin.201009263
https://doi.org/10.1002/chin.201009263
Publikováno v:
Current Alzheimer research. 5(2)
The steady state concentration of the Alzheimer's amyloid-beta peptide in the brain represents a balance between its biosynthesis from the transmembrane amyloid precursor protein (APP), its oligomerisation into neurotoxic and stable species and its d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2d96fb959a129ad51cebed21e4076f
https://pubmed.ncbi.nlm.nih.gov/18393806
https://pubmed.ncbi.nlm.nih.gov/18393806