Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lilia Bernasconi"'
Autor:
Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany, Olesya Panasenko, Lilia Bernasconi, Nicolas Hulo, Didier Picard
Publikováno v:
eLife, Vol 12 (2023)
Cells are exposed to a wide variety of internal and external stresses. Although many studies have focused on cellular responses to acute and severe stresses, little is known about how cellular systems adapt to sublethal chronic stresses. Using mammal
Externí odkaz:
https://doaj.org/article/8dccfe64e7dd4eff8c8191177c079f57
Autor:
Kaushik Bhattacharya, Samarpan Maiti, Szabolcs Zahoran, Lorenz Weidenauer, Dina Hany, Diana Wider, Lilia Bernasconi, Manfredo Quadroni, Martine Collart, Didier Picard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular chaperone Hsp90 decreases with age but whether organisms can physiologically tune expression is unclear. Here, the authors show that mammalian cells can adjust Hsp90 levels to accumulating cellular stress by translational reprogramming.
Externí odkaz:
https://doaj.org/article/98445de100014006b4ae943b041a9674
Autor:
Nastaran Mohammadi Ghahhari, Magdalena K. Sznurkowska, Nicolas Hulo, Lilia Bernasconi, Nicola Aceto, Didier Picard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The epithelial mesenchymal transition (EMT) is important in the metastatic spread of cancer cells. Here, the authors show that the EMT transcription factor, ZEB1, can modify estrogen receptor α during EMT and facilitate the migration of breast cance
Externí odkaz:
https://doaj.org/article/72e550ee41ff44c1a9cb0c079d4c632f
Autor:
Kaushik Bhattacharya, Lorenz Weidenauer, Tania Morán Luengo, Ellis C. Pieters, Pablo C. Echeverría, Lilia Bernasconi, Diana Wider, Yashar Sadian, Margreet B. Koopman, Matthieu Villemin, Christoph Bauer, Stefan G. D. Rüdiger, Manfredo Quadroni, Didier Picard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance
Externí odkaz:
https://doaj.org/article/82875625c72b4d9c8c7eaaf0131c13bc
Autor:
Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Gregory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis T. F. Tsai, David A. Agard, Len Neckers, Didier Picard
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)
Abstract Background The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor o
Externí odkaz:
https://doaj.org/article/e2196003fcc841a4afae75d1e8f78cab
Autor:
Didier Picard, S. G. D. Rüdiger, Lorenz Weidenauer, Kaushik Bhattacharya, Diana Wider, Christoph Ruediger Bauer, Lilia Bernasconi, Pablo Christian Echeverria, Manfredo Quadroni, M. Villemin, T. Moran Luengo
SUMMARYHop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38c20ca7fec2711578ee7976a6564f6
Autor:
Nathalie Picard-Riera, Lilia Bernasconi, Selvaraju Raghuram, Ursula Boschert, Rocco Cirillo, Christophe Losberger, Georg Feger, Virginia Avellana-Adalid, Ruben Papoian, Linda Kadi, Marie Kosco-Vilbois, Anne Baron-Van Evercooren, Pierre Graber
Publikováno v:
Molecular and Cellular Neuroscience. 25:707-721
We have used in vitro oligodendrocyte differentiation and the in vivo remyelination model, the cuprizone model, to identify genes regulating oligodendrocyte function and remyelination. One of the genes we identified, osteopontin (opn), is a secreted
Autor:
Ismo Ulmanen, Jukka Tenhunen, Tuula Karhunen, Carola Tilgmann, Lilia Bernasconi, Jean Piere Aubry, Johan Peränen, Kenneth Lundstrom, Pertti Panula
Publikováno v:
Lund University
The intracellular localization of soluble and membrane-bound isoforms of rat and human catechol O-methyltransferase (COMT) was studied by expressing the recombinant COMT proteins either separately or together in mammalian cell lines (HeLa and COS-7 c
Autor:
Sandrine Pouly, Catherine Salvat, Yves Sagot, Lara Joubert, Chantal Alliod, Anthony Nichols, Rob Hooft van Huijsduijnen, François Duval, Lilia Bernasconi, Christian Rommel, Rosanna Pescini Gobert, Marie-Laure Curchod, Marie-José Frossard, Isabelle Foucault, Arthur Roach
Publikováno v:
Journal of Neuroscience Research.
Oligodendrocytes generate and maintain myelin, which is essential for axonal function and protection of the mammalian central nervous system. To advance our molecular understanding of differentiation by these cells, we screened libraries of pharmacol
Autor:
Dominique Perrin, Lara Joubert, Catherine Salvat, Isabelle Foucault, Bernard Françon, Hadi Abderrahim, Marc Lamarine, Catherine Jorand-Lebrun, Francisca Zanoguera, Rosanna Pescini Gobert, Marie Laure Curchod, Helene Peixoto, Agnes Bombrun, Lilia Bernasconi, Christian Rommel, Chantal Alliod, Rob Hooft van Huijsduijnen, Chloé Vignaud, Thérèse Jomotte, Christèle Frémaux
Publikováno v:
Molecular and cellular biology. 29(6)
Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendr