Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines

Autor: Lilia Anani, Aurélien Coelho, Fabien Massicot, Johann Rogier, Jean-Bernard Behr, Jean-Luc Vasse, Carine Machado-Rodrigues

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18, pp.2632-2636. ⟨10.1039/D0OB00034E⟩

International audience; The diastereoselective conjugate addition of secondary homoallylamines, obtained in the enantioenriched form via allylmetallation of imines, to α,β-unsaturated esters is reported. This method allows access to valuable buildi

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