CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

Autor: Carmen Martin-Ruiz, Jedrzej Hoffmann, Evgeniya Shmeleva, Thomas von Zglinicki, Gavin Richardson, Lilia Draganova, Rachael Redgrave, Joanna Collerton, Helen Arthur, Bernard Keavney, Ioakim Spyridopoulos

Publikováno v: npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-6 (2020)

Abstract Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to an

Externí odkaz: https://doaj.org/article/6c6164b48b09434e8151f284b40d511a

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

Autor: Rachael Redgrave, Gavin D. Richardson, Carmen Martin-Ruiz, Bernard Keavney, Evgeniya V. Shmeleva, Thomas von Zglinicki, Ioakim Spyridopoulos, Jedrzej Hoffmann, Lilia Draganova, Joanna Collerton, Helen M. Arthur

Publikováno v: NPJ Aging and Mechanisms of Disease
Martin-Ruiz, C, Hoffmann, J, Shmeleva, E, Zglinicki, T V, Richardson, G, Draganova, L, Redgrave, R, Collerton, J, Arthur, H, Keavney, B & Spyridopoulos, I 2020, ' CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians ', npj Aging and Mechanisms of Disease, vol. 6, no. 1, 3 . https://doi.org/10.1038/s41514-019-0041-y
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-6 (2020)

Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8528db76f681704db83a8bf339711cf
https://doi.org/10.1038/s41514-019-0041-y

152 Circulating non-classical monocytes are preferentially depleted from the circulation immediately after reperfusion in stemi patients and are associated with patient outcomes

Autor: Helen M. Arthur, Lilia Draganova, Rajiv Das, Ioakim Spyridopoulos, Evgeniya V. Shmeleva, Karim Bennaceur, Alan Bagnall, Bernard Keavney, Simi Ali, Azfar Zaman, Mohaned Egred, Stephen Boag, Nicholas Howard, Sarah Marsh

Publikováno v: Basic Science.

Background In patients with acute myocardial infarction (MI), monocytes are rapidly recruited to the injured tissue, where they contribute to the inflammatory milieu. Different monocyte subsets exhibit distinct roles. Classical monocytes (CD16-CCR2 +

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4622bcb1143d6c6f492c78ca5516539d
https://doi.org/10.1136/heartjnl-2018-bcs.148

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells

Autor: Gavin David, Richardson, Andrew, Sage, Karim, Bennaceur, Nayef, Al Zhrany, Jose, Coelho-Lima, Emily, Dookun, Lilia, Draganova, Gabriele, Saretzki, David T, Breault, Ziad, Mallat, Ioakim, Spyridopoulos

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 38(6)

Atherosclerosis is an age-related disease characterized by systemic oxidative stress and low-grade inflammation. The role of telomerase and telomere length in atherogenesis remains contentious. Short telomeres of peripheral leukocytes are predictive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09c9540af6dd3f5eac8b6b8b98febb46
https://pubmed.ncbi.nlm.nih.gov/29793988