Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lili Belcastro"'
Autor:
Kristina A. Cole, John M. Maris, Stuart D. Shumway, Bruce Pawel, Daniel Martinez, Yimei Li, Lili Belcastro, JulieAnn Rader, Kirill Levin, Mike R. Russell
PDF file - 126K, Dual inhibition of Chk1 and Wee1 significantly impairs tumor growth in vivo. Mice were treated with either 30 mg/kg of single agent MK-1775 (targeting Wee1), single-agent MK-8776 (targeting Chk1) or simultaneous MK-1775 and MK-8776.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd50173a4d7ead743c4b7ed13032bb7
https://doi.org/10.1158/0008-5472.22399253
https://doi.org/10.1158/0008-5472.22399253
Autor:
Kristina A. Cole, John M. Maris, Stuart D. Shumway, Bruce Pawel, Daniel Martinez, Yimei Li, Lili Belcastro, JulieAnn Rader, Kirill Levin, Mike R. Russell
PDF file - 42K, Therapies targeting Chk1/Wee1 in combination with chemotherapy demonstrates synergy in most neuroblastoma cells. Ten neuroblastoma cell lines were tested for synergistic interactions between MK-1775 or MK-8776 in combination with eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076b7150fbb1f1219171fd176ecf0bf2
https://doi.org/10.1158/0008-5472.22399247
https://doi.org/10.1158/0008-5472.22399247
Autor:
Kristina A. Cole, John M. Maris, Stuart D. Shumway, Bruce Pawel, Daniel Martinez, Yimei Li, Lili Belcastro, JulieAnn Rader, Kirill Levin, Mike R. Russell
PDF file - 48K, Wee1 and Chk1 expression are elevated in high-risk, MYCN-amplified neuroblastoma. Primary tumors were obtained from 251 patients at diagnosis (221 high-risk, 30 low-risk; 68 MYCN amplified, 183 MYCN non-amplified), and were run on Aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd3e9015e9c5501f06c22be290af062
https://doi.org/10.1158/0008-5472.22399259
https://doi.org/10.1158/0008-5472.22399259
Autor:
Kristina A. Cole, John M. Maris, Stuart D. Shumway, Bruce Pawel, Daniel Martinez, Yimei Li, Lili Belcastro, JulieAnn Rader, Kirill Levin, Mike R. Russell
PDF file - 128K, Target engagement was validated for several cell lines via western blot analyses. Here, RPE-1, SK-N-AS, KELLY and NB-1691 cells are shown following treatment with increasing concentrations of MK-8776 and MK-1775 for 16h. Inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459a3ac2919c868a99f5ab97dad26bb9
https://doi.org/10.1158/0008-5472.22399256
https://doi.org/10.1158/0008-5472.22399256
Autor:
Kristina A. Cole, John M. Maris, Stuart D. Shumway, Bruce Pawel, Daniel Martinez, Yimei Li, Lili Belcastro, JulieAnn Rader, Kirill Levin, Mike R. Russell
PDF file - 133K, Expression and activity of Wee1 is prevalent in neuroblastoma. (A) A secondary panel of neuroblastoma cell lines demonstrated Wee1 expression and activation (evidenced by phospho-Ser642) by western blot. Cdc2 activity was observed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8405480f25f12a6552980c56225a05f9
https://doi.org/10.1158/0008-5472.22399262.v1
https://doi.org/10.1158/0008-5472.22399262.v1
Autor:
Kristina A. Cole, John M. Maris, Stuart D. Shumway, Bruce Pawel, Daniel Martinez, Yimei Li, Lili Belcastro, JulieAnn Rader, Kirill Levin, Mike R. Russell
PDF file - 55K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c095e4606352075eabea0acc9fb32d6
https://doi.org/10.1158/0008-5472.22399250
https://doi.org/10.1158/0008-5472.22399250
Autor:
Meagan Gelinske, Dan Blake, Heather Lesnik, Aaron Mack, Greg Stromberg, Lili Belcastro, Andrew Schaefer, Basak Clements, Sarah Currie, Helen Hay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8c872bbb3420bcf7f58ea3d93fab2b
https://doi.org/10.46220/2022cgt001
https://doi.org/10.46220/2022cgt001
Publikováno v:
Cell and Gene Therapy Insights. 7:183-198