Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lilah Toker"'
Autor:
Irene H. Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Lura, Omnia Shadad, Erika Fernandez-Vizarra, Cèlia Painous, Alexandra Pérez-Soriano, Yaroslau Compta, Laura Molina-Porcel, Guido Alves, Ole-Bjørn Tysnes, Christian Dölle, Gonzalo S. Nido, Charalampos Tzoulis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory c
Externí odkaz:
https://doaj.org/article/ca1314f7e4514676b9bb0eefc96db530
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Variation in cell composition can dramatically impact analyses in bulk tissue samples. A commonly employed approach to mitigate this issue is to adjust statistical models using estimates of cell abundance derived directly from omi
Externí odkaz:
https://doaj.org/article/87c277d2929745d1b8453c534ea2d91b
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Epidemiological studies of Parkinson’s disease (PD) show variable and partially conflicting findings with regard to incidence, prevalence, and mortality. These differences are commonly attributed to technical and methodological factors, in
Externí odkaz:
https://doaj.org/article/d90cf28f03db40088ad2149ddb21529e
Autor:
Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bjørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle, Charalampos Tzoulis
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-20 (2021)
Abstract Background Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and spec
Externí odkaz:
https://doaj.org/article/9fc79b5444a44fc3bd31f3e48ea449ed
Autor:
Gonzalo S. Nido, Fiona Dick, Lilah Toker, Kjell Petersen, Guido Alves, Ole-Bjørn Tysnes, Inge Jonassen, Kristoffer Haugarvoll, Charalampos Tzoulis
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract The etiology of Parkinson’s disease is largely unknown. Genome-wide transcriptomic studies in bulk brain tissue have identified several molecular signatures associated with the disease. While these studies have the potential to shed light
Externí odkaz:
https://doaj.org/article/8f3957982f06408db16e18a6596a3592
Autor:
Shreejoy J. Tripathy, Lilah Toker, Claire Bomkamp, B. Ogan Mancarci, Manuel Belmadani, Paul Pavlidis
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Patch-seq, combining patch-clamp electrophysiology with single-cell RNA-sequencing (scRNAseq), enables unprecedented access to a neuron's transcriptomic, electrophysiological, and morphological features. Here, we present a re-analysis of five patch-s
Externí odkaz:
https://doaj.org/article/845f60259a1c46a1a99fb588a6de3bba
Autor:
Shreejoy J Tripathy, Lilah Toker, Brenna Li, Cindy-Lee Crichlow, Dmitry Tebaykin, B Ogan Mancarci, Paul Pavlidis
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005814 (2017)
How neuronal diversity emerges from complex patterns of gene expression remains poorly understood. Here we present an approach to understand electrophysiological diversity through gene expression by integrating pooled- and single-cell transcriptomics
Externí odkaz:
https://doaj.org/article/9ec86e7271424462a77dccf66738ed64
Publikováno v:
F1000Research, Vol 5 (2016)
Concern about the reproducibility and reliability of biomedical research has been rising. An understudied issue is the prevalence of sample mislabeling, one impact of which would be invalid comparisons. We studied this issue in a corpus of human tran
Externí odkaz:
https://doaj.org/article/dafebf39a7484084b427313c4368d130
Publikováno v:
F1000Research, Vol 5 (2016)
Concern about the reproducibility and reliability of biomedical research has been rising. An understudied issue is the prevalence of sample mislabeling, one impact of which would be invalid comparisons. We studied this issue in a corpus of human tran
Externí odkaz:
https://doaj.org/article/2d6f28cbdb6f4138831f9f1e7bd178bd
Publikováno v:
Biological Psychiatry. 84:787-796
Background High-throughput expression analyses of postmortem brain tissue have been widely used to study bipolar disorder and schizophrenia. However, despite the extensive efforts, no consensus has emerged as to the functional interpretation of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a19d2c421831ee96571d7aaed74efa
https://doi.org/10.1016/j.biopsych.2018.07.010
https://doi.org/10.1016/j.biopsych.2018.07.010