Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Lilach Sheiner"'
Autor:
Hamza A. A. Elati, Amber L. Goerner, Bruno Martorelli Di Genova, Lilach Sheiner, Harry P. de Koning
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited. Recently, nucleotide metabolism has received much attention as a target for new antiprotozoa
Externí odkaz:
https://doaj.org/article/bce7ae6bd9e84fbcb7717fc87cda9754
Publikováno v:
Contact, Vol 5 (2022)
Membrane contact sites (MCS) are critical for cellular functions of eukaryotes, as they enable communication and exchange between organelles. Research over the last decade unravelled the function and composition of MCS between a variety of organelles
Externí odkaz:
https://doaj.org/article/4a445bd6c9614aa8bd30cd52a839b3c7
Autor:
Alexander Mühleip, Rasmus Kock Flygaard, Jana Ovciarikova, Alice Lacombe, Paula Fernandes, Lilach Sheiner, Alexey Amunts
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Structural and functional analysis of mitochondria from the human parasite Toxoplasma gondii reveals that its ATP synthase assembles into cyclic hexamers, arranged together in a form of pentagonal pyramids required for maintenance of cristae morpholo
Externí odkaz:
https://doaj.org/article/56947c119cc747a6b15d66b6a2139440
Publikováno v:
Microorganisms, Vol 10, Iss 5, p 863 (2022)
Mitochondrial ribosomes are fundamental to mitochondrial function, and thus survival, of nearly all eukaryotes. Despite their common ancestry, mitoribosomes have evolved divergent features in different eukaryotic lineages. In apicomplexans, the mitoc
Externí odkaz:
https://doaj.org/article/989467379c36460982b42a771f059da3
Autor:
Andrew E Maclean, Hannah R Bridges, Mariana F Silva, Shujing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009301 (2021)
The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important pathogens of humans causing diseases such as toxoplasmosis and malaria, depend
Externí odkaz:
https://doaj.org/article/ba08b60f25cf49998a756e68fbbcd2c7
Autor:
Gustavo D. Campagnaro, Hamza A. A. Elati, Sofia Balaska, Maria Esther Martin Abril, Manal J. Natto, Fabian Hulpia, Kelly Lee, Lilach Sheiner, Serge Van Calenbergh, Harry P. de Koning
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 710 (2022)
Toxoplasma gondii is unable to synthesize purines de novo, instead salvages them from its environment, inside the host cell, for which they need high affinity carriers. Here, we report the expression of a T. gondii Equilibrative Nucleoside Transporte
Externí odkaz:
https://doaj.org/article/7f24eee4bc2f49a3a23c0b4746b9a03e
Autor:
Jitka Richtová, Lilach Sheiner, Ansgar Gruber, Shun-Min Yang, Luděk Kořený, Boris Striepen, Miroslav Oborník
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6495 (2021)
Heme biosynthesis is essential for almost all living organisms. Despite its conserved function, the pathway’s enzymes can be located in a remarkable diversity of cellular compartments in different organisms. This location does not always reflect th
Externí odkaz:
https://doaj.org/article/fd9c193ce89f4601bfa21895f12d9d5f
Autor:
Carmen Melatti, Manuela Pieperhoff, Leandro Lemgruber, Ehmke Pohl, Lilach Sheiner, Markus Meissner
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007512 (2019)
The single mitochondrion of apicomplexan protozoa is thought to be critical for all stages of the life cycle, and is a validated drug target against these important human and veterinary parasites. In contrast to other eukaryotes, replication of the m
Externí odkaz:
https://doaj.org/article/16b16b2070df4bb69b989ba46103096f
Autor:
Marco Biddau, Anne Bouchut, Jack Major, Tracy Saveria, Julie Tottey, Ojore Oka, Marcel van-Lith, Katherine Elizabeth Jennings, Jana Ovciarikova, Amy DeRocher, Boris Striepen, Ross Frederick Waller, Marilyn Parsons, Lilach Sheiner
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006836 (2018)
Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These parasites are known to be hypersensitive to redox imbalance, yet little is understood about the cellular roles of their various re
Externí odkaz:
https://doaj.org/article/971e47a9d0744ad6bcce81deef63eef6
Autor:
Melanie J. Williams, Hernan Alonso, Marta Enciso, Saskia Egarter, Lilach Sheiner, Markus Meissner, Boris Striepen, Brian J. Smith, Christopher J. Tonkin
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Key to the virulence of apicomplexan parasites is their ability to move through tissue and to invade and egress from host cells. Apicomplexan motility requires the activity of the glideosome, a multicomponent molecular motor composed of a ty
Externí odkaz:
https://doaj.org/article/d0c460df28c34814998e886ac78c3a7f