Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

Autor: Maria Poley, Gal Chen, Noga Sharf-Pauker, Aviram Avital, Maya Kaduri, Mor Sela, Patricia Mora Raimundo, Lilach Koren, Sivan Arber, Egor Egorov, Janna Shainsky, Jeny Shklover, Avi Schroeder

Publikováno v: Advanced NanoBiomed Research, Vol 2, Iss 12, Pp n/a-n/a (2022)

Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell

Externí odkaz: https://doaj.org/article/f2cbb73ba8b34bc5ad30636da92e7fe7

JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function.

Autor: Roy Kalfon, Tom Friedman, Shir Eliachar, Rona Shofti, Tali Haas, Lilach Koren, Jacob D Moskovitz, Tsonwin Hai, Ami Aronheim

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0213081 (2019)

c-Jun dimerization protein (JDP2) and Activating Transcription Factor 3 (ATF3) are closely related basic leucine zipper proteins. Transgenic mice with cardiac expression of either JDP2 or ATF3 showed maladaptive remodeling and cardiac dysfunction. Su

Externí odkaz: https://doaj.org/article/b7e59c89d8b64732b6df441aee01e741

Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy.

Autor: Lilach Koren, Ofer Elhanani, Izhak Kehat, Tsonwin Hai, Ami Aronheim

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68396 (2013)

Cardiac hypertrophy is an adaptive response to various mechanophysical and pathophysiological stresses. However, when chronic stress is sustained, the beneficial response turns into a maladaptive process that eventually leads to heart failure. Althou

Externí odkaz: https://doaj.org/article/dee0cff1d0d44d4abaf166bb99d65a69

Abstract 1738: Sensitizing cancer cell to doxorubicin by tumor treating fields (TTFields)-induced, elevated membrane permeability

Autor: Bella Koltun, Tali Voloshin, Tal Kan, Cfir David, Lilach Koren, Yaara Porat, Alexandra Volodin, Noa Kaynan, Anat Klein-Goldberg, Rom Paz, Boris Brant, Yiftah Barsheshet, Efrat Zemer-Tov, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti

Publikováno v: Cancer Research. 83:1738-1738

Background: Tumor Treating Fields (TTFields) are electric fields that disrupt cellular processes critical for cancer cell viability and tumor progression, ultimately leading to cell death. In addition, application of TTFields to glioblastoma cells ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a59d4e6334884cd860a78673887179e0
https://doi.org/10.1158/1538-7445.am2023-1738

Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer Treatment and Fertility

Autor: Maria Poley, Patricia Mora-Raimundo, Yael Shammai, Maya Kaduri, Lilach Koren, Omer Adir, Jeny Shklover, Janna Shainsky-Roitman, Srinivas Ramishetti, Francis Man, Rafael T. M. de Rosales, Assaf Zinger, Dan Peer, Irit Ben-Aharon, Avi Schroeder

Publikováno v: ACS Nano
Poley, M, Mora-Raimundo, P, Shammai, Y, Kaduri, M, Koren, L, Adir, O, Shklover, J, Shainsky-Roitman, J, Ramishetti, S, Man, F, T. M. de Rosales, R, Zinger, A, Peer, D, Ben-Aharon, I & Schroeder, A 2022, ' Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer Treatment and Fertility ', ACS Nano, vol. 16, no. 4, pp. 5246-5257 . https://doi.org/10.1021/acsnano.1c07237

Throughout the female menstrual cycle, physiological changes occur that affect the biodistribution of nanoparticles within the reproductive system. We demonstrate a 2-fold increase in nanoparticle accumulation in murine ovaries and uterus during ovul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0869c43327bc4ad3967994d83e253ef0
https://europepmc.org/articles/PMC7613117/