Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lila Ramaiah"'
Autor:
Cynthia M. Rohde, Claudia Lindemann, Michael Giovanelli, Rani S. Sellers, Jan Diekmann, Shambhunath Choudhary, Lila Ramaiah, Annette B. Vogel, Yana Chervona, Alexander Muik, Ugur Sahin
Publikováno v:
Vaccines, Vol 11, Iss 2, p 417 (2023)
The emergence of SARS-CoV-2 at the end of 2019 required the swift development of a vaccine to address the pandemic. Nonclinical GLP-compliant studies in Wistar Han rats were initiated to assess the local tolerance, systemic toxicity, and immune respo
Externí odkaz:
https://doaj.org/article/8173e5bc40354988b9d1682a782cfb3e
Autor:
A. Eric Schultze, Lila Ramaiah
Publikováno v:
Toxicologic pathology. 50(7)
This session, held during the 41st Annual STP Symposium, focused on mechanisms of decreased erythropoiesis and erythroid cell injury. The speakers provided comprehensive overviews of physiologic and pathologic erythropoiesis, reviewed various mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fd361789cf98bc6cb863999967fd7f
https://pubmed.ncbi.nlm.nih.gov/36062427
https://pubmed.ncbi.nlm.nih.gov/36062427
Autor:
William Siska, Ara Gupta, Denise Bounous, Holly Jordan, Laura Boone, Allison Vitsky, Adeyemi O Adedeji, Michael R. Logan, Adam D. Aulbach, Laura Cregar, Tara Arndt, Anne Provencher, Niraj Tripathi, Lila Ramaiah
Publikováno v:
Veterinary Clinical Pathology. 48:383-388
The interpretation of clinical pathology results from nonclinical safety studies is a fundamental component in hazard identification of new drug candidates. The ever-increasing complexity of nonclinical safety studies and sophistication of modern ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10f4972abd750e087a2f679ab5d85fa
https://doi.org/10.1111/vcp.12773
https://doi.org/10.1111/vcp.12773
Autor:
Lila Ramaiah, Douglas A. Keller, Michael Merz, David Brott, Silvia Lentini, Lucas Westcott‐Baker, Paul B. Watkins, Shashi K. Ramaiah, David L. Bourdet, Ann Marie Stanley, Rachel J. Church, Sharin E. Roth, Ajit Dash, Philip J. Sherratt, Mark I. Avigan, John Marcinak
Publikováno v:
Clinical Pharmacology and Therapeutics
The diagnosis and management of drug-induced liver injury (DILI) remains a challenge in clinical trials in drug development. The qualification of emerging biomarkers capable of predicting DILI soon after the initiation of treatment, differentiating D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b21112abd059a7095cf1e95b7259e
http://europepmc.org/articles/PMC7006882
http://europepmc.org/articles/PMC7006882
Autor:
Ara Gupta, Tara Arndt, Michael R. Logan, Adam D. Aulbach, Anne Provencher, Lila Ramaiah, Laura Boone, Holly Jordan, William Siska, Denise Bounous, Allison Vitsky, Adeyemi O Adedeji, Niraj Tripathi, Laura Cregar
Publikováno v:
Veterinary Clinical Pathology. 48:389-399
Clinical pathology reporting practices are diverse among individuals and organizations involved in nonclinical toxicology studies. Clear, informative, and consistent reporting of clinical pathology results increases their value and avoids misinterpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f0703c947358b5be92ad4c967c485
https://doi.org/10.1111/vcp.12772
https://doi.org/10.1111/vcp.12772
Autor:
Linna Wang, Kristina D. Chadwick, Alicja Batog, Ting Su, Renuka C Pilutla, Raja Mangipudy, Bonnie Wang, Qin C Ji, Thomas Brodie, Lila Ramaiah
Publikováno v:
The AAPS Journal. 22
Microsampling techniques enable the minimization of blood collection volume from animals and subsequent handling of the blood samples or their derived plasma or serum samples. This offers advantages over conventional large-volume sampling, such as el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db4d43fe8e7dfd46efbc6a7e0448ef6
https://doi.org/10.1208/s12248-020-00438-z
https://doi.org/10.1208/s12248-020-00438-z
Autor:
J. Eric McDuffie, William J. Reagan, Joanna Harding, James D. Smith, Dominique Brees, Tanja S. Zabka, Magali Guffroy, Deidre A. Dalmas, Jean-Charles Gautier, Lila Ramaiah, Alison Wolfreys, John E. Burkhardt, A. Eric Schultze, Warren E. Glaab
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 120
Pharmaceutical and biotechnology companies rarely disclose their use of translational emerging safety biomarkers (ESBs) during drug development, and the impact of ESB use on the speed of drug development remains unclear. A cross-industry survey of 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b5cd09e29bfbf7127c37f6846504a0
https://pubmed.ncbi.nlm.nih.gov/33387566
https://pubmed.ncbi.nlm.nih.gov/33387566
Autor:
Betty Pettersen, Lila Ramaiah, Nathanael G. Lintner, Kelly M. Knee, S. Denise Field, Reema Jasuja, Youngwook Ahn, Lindsay Tomlinson, Amey Barakat, Brendon Kapinos, Zane Wenzel
Publikováno v:
Blood. 136:27-28
Sickle cell disease (SCD) is a severe genetic disorder caused by a mutation in hemoglobin (b6Glu-Val), which allows the mutant hemoglobin to assemble into long polymers when deoxygenated. Over time, these polymers build up and deform red blood cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95d6b76f28888a18ef8f33b9c6205ac3
https://doi.org/10.1182/blood-2020-142052
https://doi.org/10.1182/blood-2020-142052
Publikováno v:
Toxicologic Pathology. 45:223-237
The continuing education course on integrating clinical and anatomical pathology data was designed to communicate the importance of using a weight of evidence approach to interpret safety findings in toxicology studies. This approach is necessary, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a2df0a81916c4022e67212e43aa1c21
https://doi.org/10.1177/0192623316677068
https://doi.org/10.1177/0192623316677068
Autor:
Lila Ramaiah, Daniela Ennulat, Denise Bounous, Lindsay Tomlinson, Allison Vitsky, Niraj Tripathi, Valerie G. Barlow, Florence Poitout-Belissent
Publikováno v:
Toxicologic Pathology. 44:163-172
The Society of Toxicologic Pathology formed a working group in collaboration with the American Society for Veterinary Clinical Pathology to provide recommendations for the appropriate inclusion of clinical pathology evaluation in recovery arms of non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce77299899fd0025f094d31022c351d9
https://doi.org/10.1177/0192623315624165
https://doi.org/10.1177/0192623315624165