Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Lila E Mullany"'
Autor:
Martha L Slattery, Lila E Mullany, Lori C Sakoda, Roger K Wolff, Wade S Samowitz, Jennifer S Herrick
Publikováno v:
Cancer Informatics, Vol 17 (2018)
Mitogen-activated protein kinase (MAPK) pathways regulate many cellular functions including cell proliferation and apoptosis. We examined associations of differential gene and microRNA (miRNA) expression between carcinoma and paired normal mucosa for
Externí odkaz:
https://doaj.org/article/207ecfcd04d94433a46dc325a254eaf3
Publikováno v:
Cancer Informatics, Vol 16 (2017)
Background: Determination of functional pathways regulated by microRNAs (miRNAs), while an essential step in developing therapeutics, is challenging. Some miRNAs have been studied extensively; others have limited information. In this study, we focus
Externí odkaz:
https://doaj.org/article/d632b07c959f4212829dc0dab56f737a
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154177 (2016)
microRNAs (miRNA) repress messenger RNAs post-transcriptionally through binding to the 3' UTR of the mRNA with the miRNA seed region. It has been purported that longer seed regions have a greater efficacy on mRNA repression. We tested this hypothesis
Externí odkaz:
https://doaj.org/article/88a885ecfbf04af9880518583d9fefb5
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162077 (2016)
It has been proposed that miRNAs are involved in the control of telomeres. We test that hypothesis by examining the association between miRNAs and telomere length (TL). Additionally, we evaluate if genetic variation in telomerase reverse transcriptas
Externí odkaz:
https://doaj.org/article/96acc436f3624ea8abbcb17dff3bbd50
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143894 (2015)
IntroductionMicroRNAs (miRNAs) regulate messenger RNAs (mRNAs) and as such have been implicated in a variety of diseases, including cancer. MiRNAs regulate mRNAs through binding of the miRNA 5' seed sequence (~7-8 nucleotides) to the mRNA 3' UTRs; po
Externí odkaz:
https://doaj.org/article/24aa89f0794144ccb6b6a832509728f4
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134406 (2015)
Several diet and lifestyle factors may impact health by influencing oxidative stress levels. We hypothesize that level of cigarette smoking, alcohol, anti-inflammatory drugs, and diet alter gene expression. We analyzed RNA-seq data from 144 colon can
Externí odkaz:
https://doaj.org/article/a3d500fe8be840248e0952243536450c
Autor:
Lila E. Mullany, Wade S. Samowitz, Martha L. Slattery, Roger K. Wolff, Lori C. Sakoda, John R. Stevens, Jennifer S. Herrick
Publikováno v:
Genes & Cancer
JAK-STAT signaling influences many downstream processes that, unchecked, contribute to carcinogenesis and metastasis. MicroRNAs (miRNAs) are hypothesized as a mechanism to prevent uncontrolled growth from continuous JAK-STAT activation. We investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7107d9230903f191e803739e8ed38b44
https://doi.org/10.18632/genesandcancer.177
https://doi.org/10.18632/genesandcancer.177
Autor:
Jennifer S. Herrick, Lila E. Mullany, Martha L. Slattery, Wade S. Samowitz, Roger K. Wolff, John R. Stevens, Lori C. Sakoda
Publikováno v:
Genes & Cancer
Uncontrolled cell replication is a key component of carcinogenesis. MicroRNAs (miRNAs) regulate genes involved in checkpoints, DNA repair, and genes encoding for key proteins regulating the cell cycle. We investigated how miRNAs and mRNAs in colorect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a654060996b5e8a6f19f8edaaa8c810
https://doi.org/10.18632/genesandcancer.167
https://doi.org/10.18632/genesandcancer.167
Autor:
Roger K. Wolff, Lila E. Mullany, Martha L. Slattery, John R. Stevens, Jennifer S. Herrick, Wade S. Samowitz
Publikováno v:
Genes, Chromosomes & Cancer
Transcription factors (TFs) and microRNAs (miRNAs) regulate gene expression: TFs by influencing messenger RNA (mRNA) transcription and miRNAs by influencing mRNA translation and transcript degradation. Additionally, miRNAs and TFs alter each other's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2e8f866ca7d7bfaa0bf332ae4beba0
https://doi.org/10.1002/gcc.22520
https://doi.org/10.1002/gcc.22520
Autor:
Martha L. Slattery, Lori C. Sakoda, John R. Stevens, Roger K. Wolff, Lila E. Mullany, Wade S. Samowitz, Jennifer S. Herrick
Publikováno v:
Oncotarget
Mathematics and Statistics Faculty Publications
Mathematics and Statistics Faculty Publications
The Wnt-signaling pathway functions in regulating cell growth and thus is involved in the carcinogenic process of several cancers, including colorectal cancer. We tested the hypothesis that multiple genes in this signaling pathway are dysregulated an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56ee918756ce06a3e1034caca10657f
http://europepmc.org/articles/PMC5814196
http://europepmc.org/articles/PMC5814196