Precapillary sphincters maintain perfusion in the cerebral cortex

Autor: Changsi Cai, Stefan Andreas Zambach, Lila Khennouf, Reena Prity Murmu, Aske G. K. Jensen, Jonas C. Fordsmann, Søren Grubb, Martin Lauritzen, Bjørn Olav Hald

Publikováno v: Grubb, S, Cai, C, Hald, B O, Khennouf, L, Murmu, R P, Jensen, A G K, Fordsmann, J, Zambach, S & Lauritzen, M 2020, ' Precapillary sphincters maintain perfusion in the cerebral cortex ', Nature Communications, vol. 11, no. 1, 395 . https://doi.org/10.1038/s41467-020-14330-z
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47307dfff3ce20bb2cec76a22b09734
https://curis.ku.dk/portal/da/publications/precapillary-sphincters-maintain-perfusion-in-the-cerebral-cortex(5c39d6e3-93ac-4008-bf25-2295376394a1).html

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Autor: Chanawee Hirunpattarasilp, Takaomi C. Saido, Huma Sethi, Pablo Izquierdo, Vasiliki Kyrargyri, Anusha Mishra, Wenhui Huang, Thomas Pfeiffer, Angela Richard-Loendt, Sebastian Brandner, Nils Korte, David Attwell, Ross Nortley, Takashi Saito, Zane Jaunmuktane, Lila Khennouf, Christian Madry, Hui Gong

Publikováno v: Science

Pericytes put the squeeze on cognition Like a computer, the brain needs a reliable source of power, which is provided as oxygen and glucose in the blood. However, in many neurological disorders this energy supply is disrupted. Brain blood flow is con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bdb60a98720cd382437ece4c327c27

Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1

Autor: Lila, Khennouf, Bodil, Gesslein, Barbara Lykke, Lind, Arn M J M, van den Maagdenberg, Martin, Lauritzen

Publikováno v: Annals of neurology. 80(2)

Familial hemiplegic migraine type 1 (FHM1) is a subtype of migraine with aura caused by a gain-of-function mutation in the pore-forming α1 subunit of CaV 2.1 (P/Q-type) calcium channels. However, the mechanisms underlying how the disease is brought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aa1c5b71d8ff83ec6cd2f18db4b0919
https://pubmed.ncbi.nlm.nih.gov/27314908