Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Lil Pabon"'
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Autor:
Kris G. Alavattam, Katie A. Mitzelfelt, Giancarlo Bonora, Paul A. Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J. Palpant, William S. Noble, Charles E. Murry
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 159-174 (2023)
Summary: Vascular endothelial cells are a mesoderm-derived lineage with many essential functions, including angiogenesis and coagulation. The gene-regulatory mechanisms underpinning endothelial specialization are largely unknown, as are the roles of
Externí odkaz:
https://doaj.org/article/5f7f366be7be4a3e89f754bffcd612c1
Autor:
Alessandro Bertero, Paul A. Fields, Vijay Ramani, Giancarlo Bonora, Galip G. Yardimci, Hans Reinecke, Lil Pabon, William S. Noble, Jay Shendure, Charles E. Murry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent spli
Externí odkaz:
https://doaj.org/article/a51e8f8741a942b2bf348aa7a7f3475f
Autor:
Kai-Chun Yang, MD, Astrid Breitbart, MD, Willem J. De Lange, PhD, Peter Hofsteen, PhD, Akiko Futakuchi-Tsuchida, BS, Joy Xu, MSE, Cody Schopf, BS, Maria V. Razumova, PhD, Alex Jiao, PhD, Robert Boucek, MD, Lil Pabon, PhD, Hans Reinecke, PhD, Deok-Ho Kim, PhD, J. Carter Ralphe, MD, Michael Regnier, PhD, Charles E. Murry, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)
Summary: A novel myosin heavy chain 7 mutation (E848G) identified in a familial cardiomyopathy was studied in patient-specific induced pluripotent stem cell–derived cardiomyocytes. The cardiomyopathic human induced pluripotent stem cell–derived c
Externí odkaz:
https://doaj.org/article/55e66573abed49ff8e6ea65cc4f0d1b0
Autor:
Peter Hofsteen, Aaron Mark Robitaille, Nicholas Strash, Nathan Palpant, Randall T. Moon, Lil Pabon, Charles E. Murry
Publikováno v:
iScience, Vol 2, Iss , Pp 88-100 (2018)
Summary: Cardiac development requires coordinated biphasic regulation of the WNT/β-catenin signaling pathway. By intersecting gene expression and loss-of-function siRNA screens we identified Alpha Protein Kinase 2 (ALPK2) as a candidate negative reg
Externí odkaz:
https://doaj.org/article/7af71fc9827042cf9fe6669709f29e0f
Autor:
Nathan J. Palpant, Yuliang Wang, Brandon Hadland, Rebecca J. Zaunbrecher, Meredith Redd, Daniel Jones, Lil Pabon, Rajan Jain, Jonathan Epstein, Walter L. Ruzzo, Ying Zheng, Irwin Bernstein, Adam Margolin, Charles E. Murry
Publikováno v:
Cell Reports, Vol 20, Iss 7, Pp 1597-1608 (2017)
We analyzed chromatin dynamics and transcriptional activity of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) and KDR+/CD34+ endothelial cells generated from different mesodermal origins. Using an unbiased algorithm to hiera
Externí odkaz:
https://doaj.org/article/e989b68c8d95474a80bdd72eab2acc56
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 278-289 (2017)
We hypothesized that the neonatal rat heart would bring transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult size. In neonatal rat heart, engrafted hiPSC derivatives developed partially
Externí odkaz:
https://doaj.org/article/d4f6075a460d4ab68a2943a6c93abd82
Autor:
Josè Manuel Pioner, Alice W. Racca, Jordan M. Klaiman, Kai-Chun Yang, Xuan Guan, Lil Pabon, Veronica Muskheli, Rebecca Zaunbrecher, Jesse Macadangdang, Mark Y. Jeong, David L. Mack, Martin K. Childers, Deok-Ho Kim, Chiara Tesi, Corrado Poggesi, Charles E. Murry, Michael Regnier
Publikováno v:
Stem Cell Reports, Vol 6, Iss 6, Pp 885-896 (2016)
Summary: Tension production and contractile properties are poorly characterized aspects of excitation-contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Previous approaches have been limited due to the sma
Externí odkaz:
https://doaj.org/article/fcea7251262e4c4781ea99c51aaabcc4
Autor:
Desy S. Lee, Jyh-Hong Chen, David J. Lundy, Chung-Hung Liu, Shiaw-Min Hwang, Lil Pabon, Ru-Chi Shieh, Chien-Chang Chen, Sheng-Nan Wu, Yu-Ting Yan, Sho-Tone Lee, Po-Min Chiang, Shu Chien, Charles E. Murry, Patrick C.H. Hsieh
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 1960-1967 (2015)
Pluripotent-cell-derived cardiomyocytes have great potential for use in research and medicine, but limitations in their maturity currently constrain their usefulness. Here, we report a method for improving features of maturation in murine and human e
Externí odkaz:
https://doaj.org/article/1e5368eca16c4c6fb87703916969648c
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126259 (2015)
BackgroundMaternal smoking is a risk factor for low birth weight and other adverse developmental outcomes.ObjectiveWe sought to determine the impact of standard tobacco cigarettes and e-cigarettes on heart development in vitro and in vivo.MethodsZebr
Externí odkaz:
https://doaj.org/article/69d517d86a3a494693fd388fcf240caf
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11134 (2010)
Wnt/beta-catenin signaling is an important regulator of differentiation and morphogenesis that can also control stem cell fates. Our group has developed an efficient protocol to generate cardiomyocytes from human embryonic stem (ES) cells via inducti
Externí odkaz:
https://doaj.org/article/e536470824d54784afade1576f5ad104