Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Lijnzaad P"'
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 10, Pp 1-16 (2020)
Abstract Protein–DNA interactions are dynamic, and these dynamics are an important aspect of chromatin‐associated processes such as transcription or replication. Due to a lack of methods to study on‐ and off‐rates across entire genomes, prote
Externí odkaz:
https://doaj.org/article/1b744990507c44a588fd58f2853d4b9b
Autor:
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L. van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H. D. Kerstens, Lindy L. Visser, Maarten Rookmaaker, Marianne Verhaar, Godelieve A. M. Tytgat, Patrick Kemmeren, Ronald R. de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C. Rios, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Ruben van Boxtel, Frank C. P. Holstege, Hans Clevers, Jarno Drost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different
Externí odkaz:
https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d988
Autor:
Saman Amini, Annika Jacobsen, Olga Ivanova, Philip Lijnzaad, Jaap Heringa, Frank C P Holstege, K Anton Feenstra, Patrick Kemmeren
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1007061 (2019)
Genetic interactions, a phenomenon whereby combinations of mutations lead to unexpected effects, reflect how cellular processes are wired and play an important role in complex genetic diseases. Understanding the molecular basis of genetic interaction
Externí odkaz:
https://doaj.org/article/9065b05da34441719fe9147f6f4f70ab
Autor:
Aleksandra Pawlik, Celia W.G. van Gelder, Aleksandra Nenadic, Patricia M. Palagi, Eija Korpelainen, Philip Lijnzaad, Diana Marek, Susanna-Assunta Sansone, John Hancock, Carole Goble
Publikováno v:
F1000Research, Vol 6 (2017)
Quality training in computational skills for life scientists is essential to allow them to deliver robust, reproducible and cutting-edge research. A pan-European bioinformatics programme, ELIXIR, has adopted a well-established and progressive program
Externí odkaz:
https://doaj.org/article/52f4de1c13964cbb8b9a873101b0d89b
Autor:
Eoghan O'Duibhir, Philip Lijnzaad, Joris J Benschop, Tineke L Lenstra, Dik van Leenen, Marian JA Groot Koerkamp, Thanasis Margaritis, Mariel O Brok, Patrick Kemmeren, Frank CP Holstege
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 6, Pp 1-14 (2014)
Abstract Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such experiments may involve indirect effects, these frequently remain uncharacterized.
Externí odkaz:
https://doaj.org/article/632580814a554de6a7ae1d2d159fbd1a
Autor:
Deloukas, P., Schuler, G. D., Gyapay, G., Beasley, E. M., Soderlund, C., Rodriguez-Tomé, P., Hui, L., Matise, T. C., McKusick, K. B., Beckmann, J. S., Bentolila, S., Birren, B. B., Browne, J., Butler, A., Castle, A. B., Chiannilkulchai, N., Clee, C., Day, P. J. R., Dehejia, A., Dibling, T., Drouot, N., Duprat, S., Fizames, C., Fox, S., Gelling, S., Green, L., Harrison, P., Hocking, R., Holloway, E., Hunt, S., Keil, S., Lijnzaad, P., Ma, J., Mendis, A., Miller, J., Morissette, J., Muselet, D., Nusbaum, H. C., Peck, A., Rozen, S., Simon, D., Slonim, D. K., Staples, R., Stein, L. D., Stewart, E. A., Suchard, M. A., Thangarajah, T., Vega-Czarny, N., Webber, C., Wu, X., Hudson, J., Auffray, C., Nomura, N., Sikela, J. M., Polymeropoulous, M. H., James, M. R., Lander, E. S., Hudson, T. J., Myers, R. M., Cox, D. R., Weissenbach, J., Boguski, M. S., Bentley, D. R.
Publikováno v:
Science, 1998 Oct . 282(5389), 744-746.
Externí odkaz:
https://www.jstor.org/stable/2899266
Autor:
Thanasis Margaritis, Philip Lijnzaad, Dik van Leenen, Diane Bouwmeester, Patrick Kemmeren, Sander R van Hooff, Frank CP Holstege
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-6 (2009)
Abstract DNA microarray technology is a powerful tool for monitoring gene expression or for finding the location of DNA‐bound proteins. DNA microarrays can suffer from gene‐specific dye bias (GSDB), causing some probes to be affected more by the
Externí odkaz:
https://doaj.org/article/30df98edcc8f49bcbae66c69663bf88a
Publikováno v:
Current Science, 2006 Sep . 91(6), 789-795.
Externí odkaz:
https://www.jstor.org/stable/24093909
Autor:
Loes A L van de Pasch, Antony J Miles, Wilco Nijenhuis, Nathalie A C H Brabers, Dik van Leenen, Philip Lijnzaad, Markus K Brown, Jimmy Ouellet, Yves Barral, Geert J P L Kops, Frank C P Holstege
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65628 (2013)
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of SUMO-targeted ubiquitin ligases (STUbLs). Slx5/8 has been implicated in genome stability and transcription, but the precise contribution is unclear. To
Externí odkaz:
https://doaj.org/article/adb16228f63c4339ad1d4a5aec022f62
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