Výsledky vyhledávání

Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PAN Endonuclease Inhibitors

Autor: Yixian Liao, Yilu Ye, Mingjian Liu, Zhihao Liu, Jinshen Wang, Baixi Li, Lijian Huo, Yilian Zhuang, Liye Chen, Jianxin Chen, Yongfeng Gao, Xiaoyun Ning, Sumei Li, Shuwen Liu, Gaopeng Song

Publikováno v: Journal of Medicinal Chemistry. 66:188-219

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::728cb4ec1b20f219e61fa5889ea8033b
https://doi.org/10.1021/acs.jmedchem.2c00857

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Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PA

Autor: Yixian, Liao, Yilu, Ye, Mingjian, Liu, Zhihao, Liu, Jinshen, Wang, Baixi, Li, Lijian, Huo, Yilian, Zhuang, Liye, Chen, Jianxin, Chen, Yongfeng, Gao, Xiaoyun, Ning, Sumei, Li, Shuwen, Liu, Gaopeng, Song

Publikováno v: Journal of medicinal chemistry.

Influenza PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::786ef8c480bfa346ce6719f2a01663fe
https://pubmed.ncbi.nlm.nih.gov/36521178

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Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein

Autor: Hui Li, Chen Cheng, Shanshan Shi, Yan Wu, Yongfeng Gao, Zhihao Liu, Mingjian Liu, Zhaodong Li, Lijian Huo, Xiaoyan Pan, Shuwen Liu, Gaopeng Song

Publikováno v: European journal of medicinal chemistry. 238

The COVID-19 pandemic generates a global threat to public health and continuously emerging SARS-CoV-2 variants bring a great challenge to the development of both vaccines and antiviral agents. In this study, we identified UA-18 and its optimized anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e6f94ce3c040838b5f6edf130c6f01
https://pubmed.ncbi.nlm.nih.gov/35551037

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Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PA

Autor: Yixian, Liao, Yilu, Ye, Sumei, Li, Yilian, Zhuang, Liye, Chen, Jianxin, Chen, Zining, Cui, Lijian, Huo, Shuwen, Liu, Gaopeng, Song

Publikováno v: European journal of medicinal chemistry. 189

Currently, influenza PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfcac0baa78c69851b36a2149b1aded0
https://pubmed.ncbi.nlm.nih.gov/31954881

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Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease

Autor: Sumei Li, Lijian Huo, Yilian Zhuang, Yilu Ye, Jianxin Chen, Yixian Liao, Shuwen Liu, Zi-Ning Cui, Liye Chen, Gaopeng Song

Publikováno v: European Journal of Medicinal Chemistry. 189:112048

Currently, influenza PAN endonuclease has become an attractive target for development of new drugs to treat influenza infections. Herein we report the discovery of new PAN endonuclease inhibitors derived from a chelating agent dopamine moiety. A seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4f3f225d5878b0031c11592b936e8b2
https://doi.org/10.1016/j.ejmech.2020.112048

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