Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Lijian Hui"'
Autor:
Zhaoyuan Fang, Xiangkun Han, Yueqing Chen, Xinyuan Tong, Yun Xue, Shun Yao, Shijie Tang, Yunjian Pan, Yihua Sun, Xue Wang, Yujuan Jin, Haiquan Chen, Liang Hu, Lijian Hui, Lin Li, Luonan Chen, Hongbin Ji
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how Lkb1 deficiency dynamically regulates AST. Using the class
Externí odkaz:
https://doaj.org/article/1de59c754db845e4b4f94de55da2e5fb
Autor:
Huiying Li, Yingyin Wu, Yuhao Qiu, Xinru Li, Yuting Guan, Xiya Cao, Meizhen Liu, Dan Zhang, Sijie Huang, Longnian Lin, Lijian Hui, Xueyun Ma, Mingyao Liu, Xueli Zhang, Liren Wang, Dali Li
Publikováno v:
Advanced Science, Vol 9, Iss 34, Pp n/a-n/a (2022)
Abstract Optogenetic genome engineering is a powerful technology for high‐resolution spatiotemporal genetic manipulation, especially for in vivo studies. It is difficult to generate stable transgenic animals carrying a tightly regulated optogenetic
Externí odkaz:
https://doaj.org/article/aabf60057ef345448f3c430c5f3c7af0
Autor:
Ludi Zhang, Jian‐Yun Ge, Yun‐Wen Zheng, Zhen Sun, Chenhua Wang, Zhaoliang Peng, Baihua Wu, Mei Fang, Kinji Furuya, Xiaolong Ma, Yanjiao Shao, Nobuhiro Ohkohchi, Tatsuya Oda, Jianglin Fan, Guoyu Pan, Dali Li, Lijian Hui
Publikováno v:
Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)
Abstract Although liver‐humanized animals are desirable tools for drug development and expansion of human hepatocytes in large quantities, their development is restricted to mice. In animals larger than mice, a precondition for efficient liver huma
Externí odkaz:
https://doaj.org/article/4956c6e9b5b94dd8a2f22c16eb0aefd6
Autor:
Fei Xiao, Yajie Guo, Jiali Deng, Feixiang Yuan, Yuzhong Xiao, Lijian Hui, Yu Li, Zhimin Hu, Yuncai Zhou, Kai Li, Xiao Han, Qichen Fang, Weiping Jia, Yan Chen, Hao Ying, Qiwei Zhai, Shanghai Chen, Feifan Guo
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 138-148 (2019)
Objective: c-Jun, a prominent member of the activator protein 1 (AP-1) family, is involved in various physiology processes such as cell death and survival. However, a role of hepatic c-Jun in the whole-body metabolism is poorly understood. Methods: W
Externí odkaz:
https://doaj.org/article/bdad27fbc3e54d50b294f965f85f5570
Autor:
Lingli He, Liang Yuan, Wentao Yu, Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hang-zi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang, Lei Zhang
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108284- (2020)
Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hi
Externí odkaz:
https://doaj.org/article/3073b7c2389a4f9a8a749e7f97c29550
Autor:
Kyung Tae Lim, Jonghun Kim, Seon In Hwang, Ludi Zhang, Heonjong Han, Dasom Bae, Kee-Pyo Kim, Yi-Ping Hu, Hans R. Schöler, Insuk Lee, Lijian Hui, Dong Wook Han
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1522-1536 (2018)
Summary: Disorders of the biliary epithelium, known as cholangiopathies, cause severe and irreversible liver diseases. The limited accessibility of bile duct precludes modeling of several cholangiocyte-mediated diseases. Therefore, novel approaches f
Externí odkaz:
https://doaj.org/article/a90ed3ab22de4fc298e212ffae0444ee
Autor:
Yimeng Gao, Xiaoran Zhang, Ludi Zhang, Jin Cen, Xuan Ni, Xiaoying Liao, Chenxi Yang, Ying Li, Xiaotao Chen, Zhao Zhang, Yajing Shu, Xin Cheng, David C. Hay, Dongmei Lai, Guoyu Pan, Gang Wei, Lijian Hui
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1813-1824 (2017)
Summary: Hepatocyte-like cells (HLCs) can be generated through directed differentiation or transdifferentiation. Employing two strategies, we generated induced pluripotent stem cell (iPSC)-HLCs and hiHeps from the same donor cell line. Both types of
Externí odkaz:
https://doaj.org/article/307e7757042448d39eabd5eaba5c3f47
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 499-512 (2017)
Summary: Liver or hepatocytes transplantation is limited by the availability of donor organs. Functional hepatocytes independent of the donor sources may have wide applications in regenerative medicine and the drug industry. Recent studies have demon
Externí odkaz:
https://doaj.org/article/166c7cf56cae4d72b3d15ea7f027ca16
Autor:
Nesrin Tüysüz, Louis van Bloois, Stieneke van den Brink, Harry Begthel, Monique M. A. Verstegen, Luis J. Cruz, Lijian Hui, Luc J. W. van der Laan, Jeroen de Jonge, Robert Vries, Eric Braakman, Enrico Mastrobattista, Jan J. Cornelissen, Hans Clevers, Derk ten Berge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
There are two technical impediments for using purified Wnt proteins in serum-free stem cell cultures: rapid loss of activity and toxicity of detergents to stem cell self-renewal. Here, the authors show that lipid-stabilized Wnt3a can establish long-t
Externí odkaz:
https://doaj.org/article/c1491917e9fe4c3fa3f5944fd3318bf1
Autor:
Wenjuan Pu, Hui Zhang, Xiuzhen Huang, Xueying Tian, Lingjuan He, Yue Wang, Libo Zhang, Qiaozhen Liu, Yan Li, Yi Li, Huan Zhao, Kuo Liu, Jie Lu, Yingqun Zhou, Pengyu Huang, Yu Nie, Yan Yan, Lijian Hui, Kathy O. Lui, Bin Zhou
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Hepatocytes are highly specialized cells and their fate is determined by their position in the liver as either periportal or perivenous hepatocytes. Here, Pu et al. show through genetic lineage tracing for Mfsd2 that periportal hepatocytes proliferat
Externí odkaz:
https://doaj.org/article/8bcbb5f141f84e2ebd07ff6d5e9adba5