Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Lijia, Ma"'
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Wild‐type sortase A is an important virulence factor displaying a diverse array of proteins on the surface of bacteria. This protein display relies on the transpeptidase activity of sortase A, which is widely engineered to allow protein li
Externí odkaz:
https://doaj.org/article/ac7c996410f34a9eb5989022a0deeaef
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-based knockout screening is revolting the genetic analysis of a cellular or molecular phenotype in question but is challenged by the large size of single-guide RN
Externí odkaz:
https://doaj.org/article/5077d345502647e88b094a61c32c87fc
Autor:
Jianbo Li, Panfeng Wu, Zhoutao Cao, Guanlan Huang, Zhike Lu, Jianfeng Yan, Heng Zhang, Yangfan Zhou, Rong Liu, Hui Chen, Lijia Ma, Mengcheng Luo
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113765- (2024)
Summary: The increasing emergence of Cas9 variants has attracted broad interest, as these variants were designed to expand CRISPR applications. New Cas9 variants typically feature higher editing efficiency, improved editing specificity, or alternativ
Externí odkaz:
https://doaj.org/article/c2ab74585f1c42a3b0819013104c6643
Autor:
Heng Zhang, Jianfeng Yan, Zhike Lu, Yangfan Zhou, Qingfeng Zhang, Tingting Cui, Yini Li, Hui Chen, Lijia Ma
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-20 (2023)
Abstract Life science studies involving clustered regularly interspaced short palindromic repeat (CRISPR) editing generally apply the best-performing guide RNA (gRNA) for a gene of interest. Computational models are combined with massive experimental
Externí odkaz:
https://doaj.org/article/d881e6e86c01463aa5b6f0f3696e4ad5
Autor:
Zhenxing Yu, Zhike Lu, Jingjing Li, Yingying Wang, Panfeng Wu, Yini Li, Yangfan Zhou, Bailun Li, Heng Zhang, Yingzheng Liu, Lijia Ma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
It is still a challenge to accurately identify off-target endonuclease edits. Here the authors report PEAC-seq using a Prime Editor to insert a tag to the editing sites and enrich the tagged regions with site-specific primers for sequencing: they sho
Externí odkaz:
https://doaj.org/article/906145db752d453cb2223b7e2782e62c
Autor:
Luping He, Boling Yi, Dirui Zhang, Sining Hu, Chen Zhao, Rui Sun, Jianlin Ma, Jingbo Hou, Haibo Jia, Lijia Ma, Bo Yu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAs a novel lipoprotein ratio, baseline low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LHR) is closely related to the clinical outcomes of acute coronary syndromes (ACS) after percutaneous coronary interve
Externí odkaz:
https://doaj.org/article/80c83e17c6ef4efe8048fc05ceb49325
Autor:
Senqing Jiang, Junchen Guo, Yanwei Yin, Chao Fang, Jifei Wang, Yidan Wang, Fangmeng Lei, Sibo Sun, Xueying Pei, Ruyi Jia, Shaotao Zhang, Lulu Li, Yini Wang, Lei Xing, Huai Yu, Huimin Liu, Maoen Xu, Xuefeng Ren, Lijia Ma, Guo Wei, Jingbo Hou, Jiannan Dai, Bo Yu, Tianyu Xu, Xiaoxia Fu
Publikováno v:
Cardiology Discovery, Vol 2, Iss 2, Pp 83-88 (2022)
Abstract. Objective:. Microchannels are associated with the progression of atherosclerotic vulnerable plaques. However, in patients with culprit optical coherence tomography (OCT)-defined plaque erosion, the knowledge of microchannels and culprit les
Externí odkaz:
https://doaj.org/article/a315094a4598416380f4292a0f43a4ed
Publikováno v:
Viruses, Vol 15, Iss 10, p 1994 (2023)
Due to the variation in the SARS-CoV-2 virus, COVID-19 exhibits significant variability in severity. This presents challenges for governments in managing the allocation of healthcare resources and prioritizing health interventions. Clinical severity
Externí odkaz:
https://doaj.org/article/7c097b66ee3b40ac95e5999fed4d6268
Autor:
Taotao Sheng, Shamaine Wei Ting Ho, Wen Fong Ooi, Chang Xu, Manjie Xing, Nisha Padmanabhan, Kie Kyon Huang, Lijia Ma, Mohana Ray, Yu Amanda Guo, Ngak Leng Sim, Chukwuemeka George Anene-Nzelu, Mei Mei Chang, Milad Razavi-Mohseni, Michael A. Beer, Roger Sik Yin Foo, Raghav Sundar, Yiong Huak Chan, Angie Lay Keng Tan, Xuewen Ong, Anders Jacobsen Skanderup, Kevin P. White, Sudhakar Jha, Patrick Tan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Abstract Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most p
Externí odkaz:
https://doaj.org/article/38cedd9ca8014168bc07ffb9aa64af83
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/164a074c1c5a4911b6791668618d2c26