Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Liji Raju"'
Autor:
Philip L. Leopold, Vassilia Partali, Hans-Richard Sliwka, Rachel Jones, Liji Raju, Nada Abdul Khalique, Tarek Ibrahim, Nour Barakat, Mais Al-Kawaz, Christer L. Øpstad, Michael D. Pungente, Emile Jubeli
Publikováno v:
Molecules, Vol 17, Iss 3, Pp 3484-3500 (2012)
The success of nucleic acid delivery requires the development of safe and efficient delivery vectors that overcome cellular barriers for effective transport. Herein we describe the synthesis of a series of novel, single-chain rigid cationic carotenoi
Externí odkaz:
https://doaj.org/article/cdde7c7eaee747feacbd5488c1456277
Autor:
Vassilia Partali, Michael D. Pungente, Aseel Abu-Dayya, Tushar Khanna, Marcella Flinterman, Nada Abdul Khalique, George Dickson, Liji Raju, Hans-Richard Sliwka, Christer L. Øpstad, Linda J. Popplewell
Publikováno v:
Molecules, Vol 17, Iss 2, Pp 1138-1148 (2012)
Duchenne Muscular Dystrophy (DMD) is a common, inherited, incurable, fatal muscle wasting disease caused by deletions that disrupt the reading frame of the DMD gene such that no functional dystrophin protein is produced. Antisense oligonucleotide (AO
Externí odkaz:
https://doaj.org/article/4edbf40a96264fb08676cccf7100e8e0
Autor:
P. Parvizi-Bahktar, Helge B. Larsen, Michael D. Pungente, Nada Abdul Khalique, Liji Raju, Thomas M. Fyles, Emile Jubeli, David G. Nicholson, J. Mendez-Campos
Publikováno v:
'Organic & Biomolecular Chemistry ', vol: 14, pages: 3080-3090 (2016)
The efficiency of the transfection of a plasmid DNA encoding a galactosidase promoted by a series of pyridinium lipids in mixtures with other cationic lipids and neutral lipids was assessed in CHO-K1 cells. We identify key molecular parameters of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a4969936e11652a946df7e8aced84d
https://doi.org/10.1039/c6ob00041j
https://doi.org/10.1039/c6ob00041j
Autor:
Mohamad Abdulhai, Liji Raju, Nada Abdul Khalique, Helge B. Larsen, William P. D. Goldring, Emilie Jubeli, Amanda B. Maginty, Michael D. Pungente, David G. Nicholson
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:6364-6378
Previously we reported the synthesis and in vitro evaluation of four novel, short-chain cationic lipid gene delivery vectors, characterized by acyclic or macrocyclic hydrophobic regions composed of, or derived from, two 7-carbon chains. Herein we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fdff93481c192d0ec84b8cd9312b6b
https://doi.org/10.1016/j.bmc.2015.08.032
https://doi.org/10.1016/j.bmc.2015.08.032
Autor:
Muhammad Zeeshan, Vassilia Partali, Philip L. Leopold, Natalia Bilchuk, Hans-Richard Sliwka, Liji Raju, Emile Jubeli, Cory Zegel, Agape Chen, Christer L. Øpstad, Michael D. Pungente, Nada Abdul Khalique, Howard H. Lou
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 89:280-289
Cationic lipids are promising non-viral vectors for the cellular delivery of nucleic acids. Important considerations for the development of new delivery vectors are enhanced uptake efficiency, low toxicity and traceability. Traceable gene transfer sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46cec60bc2f9a53bb29c921e92ec9e7
https://doi.org/10.1016/j.ejpb.2014.12.011
https://doi.org/10.1016/j.ejpb.2014.12.011
Publikováno v:
Materials Today: Proceedings. 2:331-335
Cationic lipids are promising, potentially safer cellular delivery carriers of therapeutic nucleic acids compared to the more effective viral vectors. The key to improving the effectiveness of non-viral agents is unlocking the still unsolved mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be70e3e94db8c8591edd6a59e0c13f40
https://doi.org/10.1016/j.matpr.2015.04.059
https://doi.org/10.1016/j.matpr.2015.04.059
Autor:
Muhammad Zeeshan, Michael D. Pungente, Philip L. Leopold, David G. Nicholson, Vassilia Partali, Natalia Bilchuk, Howard H. Lou, Liji Raju, Nada Abdul Khalique, Christer L. Øpstad, Asma Zaidi, Aleksandra Liberska, Helge B. Larsen, Marcella Flinterman, Chinmay Surve, Emile Jubeli, Mitchell A. Izower, Hans-Richard Sliwka
Publikováno v:
Chemistry and Physics of Lipids. 183:117-136
Cationic glycol phospholipids were synthesized introducing chromophoric, rigid polyenoic C20:5 and C30:9 chains next to saturated flexible alkyl chains of variable lengths C6-20:0. Surface properties and liposome formation of the amphiphilic compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9f0e7ee60878300d7a7b361fbbd843
https://doi.org/10.1016/j.chemphyslip.2014.04.006
https://doi.org/10.1016/j.chemphyslip.2014.04.006
Autor:
David G. Nicholson, Maryem Al Manaa, Ahmed Almeer, Michael D. Pungente, Liji Raju, Paria Parvizi, Helge B. Larsen, Emile Jubeli, Thomas M. Fyles, Hebatalla Allam, Nada Abdul Khalique
Publikováno v:
International Journal of Pharmaceutics. 461:145-156
This study seeks correlations between the molecular structures of cationic and neutral lipids, the lipid phase behavior of the mixed-lipid lipoplexes they form with plasmid DNA, and the transfection efficacy of the lipoplexes. Synthetic cationic pyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9da2fc79e4b25e2cd0302add31109c
https://doi.org/10.1016/j.ijpharm.2013.11.045
https://doi.org/10.1016/j.ijpharm.2013.11.045
Autor:
Arnljot Elgsaeter, Christer L. Øpstad, Michael D. Pungente, Hans-Richard Sliwka, Philip L. Leopold, Liji Raju, Vassilia Partali, Nada Abdul Khalique, Emile Jubeli
Publikováno v:
Chemistry and Physics of Lipids. :65-73
The synthesis and self-assembling properties of a model compound in a new class of cationic phospholipids with a highly unsaturated conjugated fatty acid are described. In addition, the potential of this new lipid as a nucleic acid carrier was evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd39a2c2a25658cb4df08200e7d7e378
https://doi.org/10.1016/j.chemphyslip.2013.03.002
https://doi.org/10.1016/j.chemphyslip.2013.03.002
Autor:
Emile Jubeli, Nada Abdul Khalique, William P. D. Goldring, David G. Nicholson, Amanda B. Maginty, Helge B. Larsen, Michael D. Pungente, Liji Raju
Publikováno v:
European journal of medicinal chemistry. 125
In this communication we describe the construction of four succinic-based cationic lipids, their formulation with plasmid DNA (pDNA), and an evaluation of their in vitro gene delivery into Chinese hamster ovarian (CHO-K1) cells. The cationic lipids e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9747330a719b3a1f9a1ef9f1a0562c9f
https://pubmed.ncbi.nlm.nih.gov/27662033
https://pubmed.ncbi.nlm.nih.gov/27662033