Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Autor: Hanna Antila, Maria Ryazantseva, Dina Popova, Pia Sipilä, Ramon Guirado, Samuel Kohtala, Ipek Yalcin, Jesse Lindholm, Liisa Vesa, Vinicius Sato, Joshua Cordeira, Henri Autio, Mikhail Kislin, Maribel Rios, Sâmia Joca, Plinio Casarotto, Leonard Khiroug, Sari Lauri, Tomi Taira, Eero Castrén, Tomi Rantamäki

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthe

Externí odkaz: https://doaj.org/article/9b0a9c01a2904ac9a4a5d9e945138f61

The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development.

Autor: Antonio Di Lieto, Tomi Rantamäki, Liisa Vesa, Sudhirkumar Yanpallewar, Hanna Antila, Jesse Lindholm, Maribel Rios, Lino Tessarollo, Eero Castrén

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32869 (2012)

Previous studies suggest that the responsiveness of TrkB receptor to BDNF is developmentally regulated in rats. Antidepressant drugs (AD) have been shown to increase TrkB signalling in the adult rodent brain, and recent findings implicate a BDNF-inde

Externí odkaz: https://doaj.org/article/a38b8b7fcfd34020a6754c8504c05345

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Autor: Ramon Guirado, Sari E. Lauri, Vinicius Sato, Mikhail Kislin, Liisa Vesa, Maria Ryazantseva, Leonard Khiroug, Sâmia R.L. Joca, Jesse Lindholm, Joshua Cordeira, Ipek Yalcin, Eero Castrén, Pia Sipilä, Dina Popova, Plinio C. Casarotto, Tomi Rantamäki, Samuel Kohtala, Henri Autio, Hanna Antila, Maribel Rios, Tomi Taira

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Antila, H, Ryazantseva, M, Popova, D, Sipilä, P, Guirado, R, Kohtala, S, Yalcin, I, Lindholm, J, Vesa, L, Sato, V, Cordeira, J, Autio, H, Kislin, M, Rios, M, Joca, S, Casarotto, P, Khiroug, L, Lauri, S, Taira, T, Castrén, E & Rantamäki, T 2017, ' Isoflurane produces antidepressant effects and induces TrkB signaling in rodents ', Scientific Reports, vol. 7, no. 1, pp. 7811 . https://doi.org/10.1038/s41598-017-08166-9

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c283e5110533f9a62d72bdb5d5779c3f
https://doaj.org/article/9b0a9c01a2904ac9a4a5d9e945138f61

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

Autor: Senem Merve Fred, Liina Laukkanen, Cecilia A Brunello, Liisa Vesa, Helka Goos, Iseline Cardon, Rafael Moliner, Tanja Maritzen, Markku Varjosalo, Plinio C Casarotto, Eero Castrén

The activation of TRKB (tropomyosin-related kinase B), the receptor for brain-derived neurotrophic factor (BDNF), is a crucial step in brain plasticity. Several antidepressant drugs are reported to activate TRKB, and animals with compromised BDNF or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8f441abdb699370914dee823d7e816

The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease

Autor: Marius C. Hoener, Masami Kojima, Susanna Kemppainen, Saara Stavén, Heikki Tanila, Hennariikka Koivisto, Henri Autio, Hanna Antila, Eero Castrén, Lothar Lindemann, Elisa Kärkkäinen, Tomi Rantamäki, Liisa Vesa, Pasi Miettinen, Nina N. Karpova

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e68722 (2013)

Brain-derived neurotrophic factor (BDNF) importantly regulates learning and memory and supports the survival of injured neurons. Reduced BDNF levels have been detected in the brains of Alzheimer's disease (AD) patients but the exact role of BDNF in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4c478a0a7cc00c3310f2a15baec682
https://pubmed.ncbi.nlm.nih.gov/23844236