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Akademický článek

Cross-Reactive T Cell Response Exists in Chronic Lymphocytic Choriomeningitis Virus Infection upon Pichinde Virus Challenge

Autor: Jasmin Mischke, Sebastian Klein, Austin Seamann, Immo Prinz, Liisa Selin, Dario Ghersi, Markus Cornberg, Anke R.M. Kraft

Publikováno v: Viruses, Vol 14, Iss 10, p 2293 (2022)

Immunological memory to a previously encountered pathogen can influence the outcome of a sequential infection, which is called heterologous immunity. Lymphocytic choriomeningitis virus (LCMV) immune mice develop a NP205-specific T cell response that

Externí odkaz: https://doaj.org/article/25dabda49c694613b930194c59537936

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Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines

Autor: Christine Stabell Benn, Nelly Amenyogbe, Anders Björkman, Jorge Domínguez-Andrés, Eleanor N. Fish, Katie L. Flanagan, Sabra L. Klein, Tobias R. Kollmann, Kirsten Ohm Kyvik, Mihai G. Netea, Naja Hulvej Rod, Frederik Schaltz-Buchholzer, Frank Shann, Liisa Selin, Sanne M. Thysen, Peter Aaby

Publikováno v: Drug Safety, 46, 439-448
Benn, C S, Amenyogbe, N, Bjorkman, A, Dominguez-Andres, J, Fish, E N, Flanagan, K L, Klein, S L, Kollmann, T R, Kyvik, K O, Netea, M G, Rod, N H, Schaltz-Buchholzer, F, Shann, F, Selin, L, Thysen, S M & Aaby, P 2023, ' Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines ', Drug Safety, vol. 46, pp. 439-448 . https://doi.org/10.1007/s40264-023-01295-3
Drug Safety, 46, 5, pp. 439-448

The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against the vaccine-specific disease, may also have “non-specific effects” affecting the risk of unrelated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25515580bee3ed6a7a9fcb03af374d7e
https://hdl.handle.net/2066/292761

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Influenza-A virus specific Epstein-Barr virus lytic memory CD8 T cells in EBV sero-negative middle age adults (VIR5P.1147)

Autor: Rabinarayan Mishra, Levi Watkin, Nuray Aslan, Anna Gil, Katherine Luzuriaga, Liisa Selin

Publikováno v: The Journal of Immunology. 194:148.15-148.15

For unknown reasons 5-10% of middle-aged adults (>35 years) remain EBV-sero-negative when the virus infects the vast majority of people, and is actively shed at high titers during chronic infection. Here we show that EBV-sero-negative (EBV-SN) HLA-A2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a563314775ea3dd6f370fa42a4547e3
https://doi.org/10.4049/jimmunol.194.supp.148.15

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Heterologous protective immunity can lead to impaired activation, memory differentiation and inflation of new naive responses (VIR2P.1170)

Autor: Priti Agarwal, Anke Kraft, Levi Watkin, Laurie Kenney, Keith Daniels, alex Chen, Michael Brehm, Liisa Selin

Publikováno v: The Journal of Immunology. 194:75.9-75.9

Activation of crossreactive memory CD8 T cells leads to heterologous protective immunity. Here we question whether early activation of crossreactive memory CD8 T cells alters the activation of new naïve CD8 responses to the second virus. Pichinde vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d22c3aa772114da2567ca99fdaafd9
https://doi.org/10.4049/jimmunol.194.supp.75.9

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Crossreactive influenza A(IAV)-Specific CD4 memory cells enhance viral load during lymphocytic choriomeningitis (LCMV) infection (IRC5P.635)

Autor: Liisa Selin, Priti Agarwal, Anke Kraft, Myriam Wlodarczyk

Publikováno v: The Journal of Immunology. 194:58.18-58.18

IAV is a common human respiratory pathogen with a strong association with heterotypic and heterologous immunity. IAV-immune mice challenged with LCMV develop detrimental effects with both increased virus titers and immunopathology. Crossreactive CD8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a308ac07fe9af2064bd769629743d68
https://doi.org/10.4049/jimmunol.194.supp.58.18

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Severity of infectious mononucleosis correlates with the frequency of crossreactive influenza A/Epstein Barr virus-specific CD8+ T cells (HUM4P.301)

Autor: Liisa Selin, Levi Watkin, Anna Gil, Rabinarayan Mishra, Katherine Luzuriaga, Nuray Aslan

Publikováno v: The Journal of Immunology. 194:122.8-122.8

During EBV-associated infectious mononucleosis (IM) IAV-specific crossreactive memory T cells are activated and play a role in disease severity. In HLA-A2+ IM patients, influenza M158 (IAV-M1)-specific CD8 memory T cell responses crossreacted with tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a582d5665e8722b93d6e66f5e003ae1
https://doi.org/10.4049/jimmunol.194.supp.122.8

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Acute Epstein Barr virus-induced infectious mononucleosis leads to expansion of highly diverse CD8 T cell repertoires crossreactive with influenza A (HUM6P.249)

Autor: Anna Gil, Nuray Aslan, Rabi Mishra, Liisa Selin

Publikováno v: The Journal of Immunology. 194:190.8-190.8

The competence of T cell responses predominantly depends on how efficient T cell receptors (TCRs) are at recognizing antigenic epitopes. We show here that during acute infectious mononucleosis (IM) there was an expansion of IAV-M1-specific memory cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a9c7fad9239d15483f59dff71bc5d25
https://doi.org/10.4049/jimmunol.194.supp.190.8

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Characterization of crossreactive T cell receptors that recognize both Epstein Barr virus and influenza A virus during acute influenza A virus infection (VIR5P.1135)

Autor: InYoung Song, Anna Gil, Lawrence Stern, Liisa Selin

Publikováno v: The Journal of Immunology. 194:148.3-148.3

Crossreactive CD8+T cells that recognize both influenza A (IAV) epitope M158, and Epstein Barr virus (EBV) epitope BRLF1109, are frequently found in HLA-A*02 populations particularly during acute infection. However, whether this crossreactivity is me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6abc7899da7abf38bf28fd29b4a07d
https://doi.org/10.4049/jimmunol.194.supp.148.3

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Crossreactive Epstein-Barr virus (EBV)-influenza A virus (IAV) specific CD8 memory T cells during acute symptomatic IAV infection. (VIR2P.1022)

Autor: Rabinarayan Mishra, Anna Gil, Nuray Aslan, Katherine Luzuriaga, Liisa Selin

Publikováno v: The Journal of Immunology. 192:75.11-75.11

We previously showed that crossreactivity is common between IAV and EBV in HLA-A2+ patients during infectious mononucleosis. IAV-M1 specific CD8 T cells, along with expanded populations of IAV-M1/EBV-BRLF-1 and IAV-M1/EBV-BMLF-1 double-tetramer+ cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3814838d7300fcc618fa344c0cf7d00
https://doi.org/10.4049/jimmunol.192.supp.75.11

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Acute symptomatic influenza A virus (IAV) infection in humans leads to expansion of highly diverse CD8 T cell repertoires crossreactive with persistent Epstein Barr virus (EBV) (HUM8P.344)

Autor: Anna Gil, Rabinarayan Mishra, Nuray Aslan, Liisa Selin

Publikováno v: The Journal of Immunology. 192:185.19-185.19

The competence of T cell responses predominantly depends on how efficient T cell receptors (TCRs) are at recognizing antigenic epitopes. We show here that during acute severely symptomatic IAV infection there was an expansion of IAV-M1/EBV-BRLF1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05bfbafec19d5ab986ffa1d412ccf679
https://doi.org/10.4049/jimmunol.192.supp.185.19

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