Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Liis Karo-Astover"'
Autor:
Tatjana Meister, Heti Pisarev, Raivo Kolde, Ruth Kalda, Kadri Suija, Lili Milani, Liis Karo-Astover, Marko Piirsoo, Anneli Uusküla
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270192 (2022)
BackgroundCOVID-19 pandemic has led to overloading of health systems all over the world. For reliable risk stratification, knowledge on factors predisposing to SARS-CoV-2 infection and to severe COVID-19 disease course is needed for decision-making a
Externí odkaz:
https://doaj.org/article/cf4cfa723001441fa48c625fc0822f0e
Autor:
Alexander Karlas, Stefano Berre, Thérèse Couderc, Margus Varjak, Peter Braun, Michael Meyer, Nicolas Gangneux, Liis Karo-Astover, Friderike Weege, Martin Raftery, Günther Schönrich, Uwe Klemm, Anne Wurzlbauer, Franz Bracher, Andres Merits, Thomas F. Meyer, Marc Lecuit
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits usin
Externí odkaz:
https://doaj.org/article/a11a26eb638c455b881f87794f4e9c13
Autor:
Eva Žusinaite, Andres Merits, Kai Rausalu, Aleksei Lulla, Liis Karo-Astover, Ailar Omler, Mona Teppor, Valeria Lulla
Publikováno v:
J Virol
Alphaviruses (family Togaviridae) include both human pathogens such as chikungunya virus (CHIKV) and Sindbis virus (SINV) and model viruses such as Semliki Forest virus (SFV). The alphavirus positive-strand RNA genome is translated into nonstructural
Autor:
Raivo Kolde, Anneli Uusküla, Ruth Kalda, Kadri Suija, Lili Milani, Heti Pisarev, Tatjana Meister, Marko Piirsoo, Liis Karo-Astover
Publikováno v:
SSRN Electronic Journal.
Background COVID-19 pandemic has led to overloading of health systems all over the world. For reliable risk stratification, knowledge on factors predisposing to SARS-CoV-2 infection and to severe COVID-19 disease course is needed for decision-making
Autor:
Brett A. Lidbury, Gerald M. McInerney, Andres Merits, Suresh Mahalingam, Liis Karo-Astover, Kuo-Ching Sheng, Julian V. Melton, Bastian Thaa, Michelle Nelson, Lara J. Herrero, Peter W. Gage, Adam Taylor, Gary Ewart
Publikováno v:
Journal of Virology. 90:4150-4159
The alphaviral 6k gene region encodes the two structural proteins 6K protein and, due to a ribosomal frameshift event, the transframe protein (TF). Here, we characterized the role of the 6k proteins in the arthritogenic alphavirus Ross River virus (R
Publikováno v:
Journal of Virology
Polyprotein processing has an important regulatory role in the life cycle of positive-strand RNA viruses. In the case of alphaviruses, sequential cleavage of the nonstructural polyprotein (ns-polyprotein) at three sites eventually yields four mature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b282b46f97abf1df05bbe5dc7e1738f0
https://europepmc.org/articles/PMC6026757/
https://europepmc.org/articles/PMC6026757/
Publikováno v:
Journal of Virology
Semliki Forest virus (genus Alphavirus ) is an important model for studying regulated nonstructural (ns) polyprotein processing. In this study, we evaluated the strictness of the previously outlined cleavage rules, accounting for the timing and outco
Publikováno v:
APMIS. 115:1409-1414
Eukaryotic cells continuously produce reactive oxygen species (ROS) and have mechanisms to control ROS levels. ROS have been shown to mediate cell proliferation and transformation. We studied the effect of CuZn-superoxide dismutase (CuZnSOD) on the f
Autor:
Kairit Tints, Eva Žusinaite, Liis Karo-Astover, Pirjo Spuul, Andres Merits, Kaja Kiiver, Inga Sarand
Publikováno v:
The Journal of General Virology
The replicase of Semliki Forest virus (SFV) consists of four non-structural proteins, designated nsP1–4, and is bound to cellular membranes via an amphipathic peptide and palmitoylated cysteine residues of nsP1. It was found that mutations preventi
Publikováno v:
Virus research. 153(2)
Semliki Forest virus (SFV), an alphavirus, replicates in vertebrate host and mosquito vector cells. The virus-specific part of the replicase complex constitutes nonstructural proteins 1–4 (nsP1–nsP4) and is bound to cytoplasmic membranes by an am