Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lihren Chen"'
Autor:
John C. McKew, Lihren Chen, Elizabeth Murphy, Weiheng Wang, Tam Steve Yik-Kai, Wen Zhang, James D. Clark, Katherine L. Lee, Cheryl Nickerson-Nutter, Xin Xu, Debra G. Goodwin, Marina W.H. Shen
Publikováno v:
Journal of Medicinal Chemistry. 52:1156-1171
The cPLA(2)alpha inhibitors we reported earlier were potent in both isolated enzyme and rat whole blood assays but have high plogD(7.4). To address these issues, reactions of electrophilic sulfonamides 9-12 were employed to incorporate various hetero
Autor:
Manus Ipek, Zhao-Kui Wan, Eva Binnun, Tarek S. Mansour, Jason Shaoyun Xiang, Seung Hahm, Xiangping Li, Huan-Qiu Li, James Tobin, Eddine Saiah, Vipin Suri, Yuzhe Xing, May Tam, Lihren Chen, John C. McKew, Jill Nunez, Xin Xu
Publikováno v:
Journal of Medicinal Chemistry. 51:4068-4071
11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol. Evidence suggests that selective inhibition of 11beta-HSD1 could treat diabetes and metabolic syndrome. Presented herein are the synthesis, st
Autor:
Megan A. Foley, M. Sherry Ku, Cheryl Nickerson-Nutter, Lihren Chen, Weiheng Wang, Manjunath K. Ramarao, Marina W.H. Shen, Debra G. Goodwin, Katherine L. Lee, Tam Steve Yik-Kai, Jaechul Shim, Mark L. Behnke, SooPeang Khor, John C. McKew, Xin Xu, Steven J. Kirincich, Frank Lovering, Frances Donahue, James D. Clark
Publikováno v:
Journal of Medicinal Chemistry. 50:1380-1400
The synthesis and structure-activity relationship of a series of indole inhibitors of cytosolic phospholipase A2alpha (cPLA2alpha, type IVA phospholipase) are described. Inhibitors of cPLA2alpha are predicted to be efficacious in treating asthma as w
Publikováno v:
Tetrahedron Letters. 40:5449-5453
The C1C8 and C9C24 fragments of (−)-discodermolide, the antipode of the marine natural product (+)-discodermolide, have been synthesized with excellent stereoselectivities. These syntheses feature the utilization of the isoxazolidine-mediated
Autor:
Enrico A. Stura, Lihren Chen, Eduardo García-Junceda, Chi-Huey Wong, Ian A. Wilson, Sutapa Ghosh
Publikováno v:
Proteins: Structure, Function, and Genetics. 22:67-72
X-ray quality crystals of class I-deoxyribose-5-phosphate aldolase from Escherichia coli have been obtained for the unliganded enzyme and in complex with its substrate, 2-deoxyribose-5-phosphate. The enzyme catalyzes the reversible cleavage of 2-deox
Autor:
Harrie J. M. Gijsen, Eduardo García-Junceda, D. H. Steensma, Olga Blanco, Chi-Huey Wong, Lihren Chen
Publikováno v:
Journal of the American Chemical Society. 117:3333-3339
Publikováno v:
Journal of the American Chemical Society. 116:6191-6194
Publikováno v:
ChemInform. 22
In summary, this paper describes a simple and practical enzymatic approach to the preparation of both R and S enantiomers of glycidaldehyde diethyl acetal and 3-(benzyloxy)- and 3-(allyloxy)-1,2-epoxypropane useful for organic synthesis. The starting
Publikováno v:
ChemInform. 22