Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Lihong Zhan"'
Autor:
Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.
Externí odkaz:
https://doaj.org/article/1f855da0da7c4c2995106bb45af63b8f
Autor:
Lihong Zhan, Li Fan, Lay Kodama, Peter Dongmin Sohn, Man Ying Wong, Gergey Alzaem Mousa, Yungui Zhou, Yaqiao Li, Li Gan
Publikováno v:
eLife, Vol 9 (2020)
Microglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse brains can survive without CSF1R signaling and reestablish the
Externí odkaz:
https://doaj.org/article/38de165a5edb4d8e822dcdefe18cdd9b
Autor:
Lihong Zhan, Grietje Krabbe, Fei Du, Ian Jones, Meredith C Reichert, Maria Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-Hyun Cho, Faten Sayed, Yaqiao Li, David Le, Yungui Zhou, Yin Shen, Brian West, Li Gan
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000134 (2019)
Microglia are resident immune cells that play critical roles in maintaining the normal physiology of the central nervous system (CNS). Remarkably, microglia have an intrinsic capacity to repopulate themselves after acute ablation. However, the underl
Externí odkaz:
https://doaj.org/article/20a6e03402384b01a796884e40f2c6d4
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57214 (2013)
Cytosolic aggregation of the nuclear RNA-binding protein TDP-43 is a histopathologic signature of degenerating neurons in amyotrophic lateral sclerosis (ALS), and mutations in the TARDBP gene encoding TDP-43 cause dominantly inherited forms of this c
Externí odkaz:
https://doaj.org/article/c645b9604db14decae0770f39639484e
Autor:
Naval P Shanware, Lihong Zhan, John A Hutchinson, Sang Hwa Kim, Leah M Williams, Randal S Tibbetts
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12173 (2010)
Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles
Externí odkaz:
https://doaj.org/article/70967b6e9d904f0facf833fe18b14c88
Autor:
Hongwei Duan, Fang Wang, Ke Wang, Shuai Yang, Rong Zhang, Chen Xue, Lihong Zhang, Xiaofei Ma, Xianghong Du, Jian Kang, Yong Zhang, Xingxu Zhao, Junjie Hu, Longfei Xiao
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Follicular cysts contribute significantly to reproductive loss in high-yield dairy cows. This results from the death of follicular granulosa cells (GCs) caused by oxidative stress. Quercetin is known to have significant antioxidan
Externí odkaz:
https://doaj.org/article/e31e7ed1cfe04b9a8808ce774de44e4f
Autor:
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I. Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E. Pizzo, Rachel Prorok, Elliot Thomsen, Laura M. Bartos, Philipp Beumers, Anja Capell, Sonnet S. Davis, Lis de Weerd, Jason C. Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T. Kunte, Lea H. Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O. Torres, Hoang N. Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H. Suh, Robert G. Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y. Joy Yu Zuchero, Dolo Diaz, Mark S. Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J. Watts, Christian Haass, Joseph W. Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E. Sanchez, Kathryn M. Monroe
Publikováno v:
Nature neuroscience 26, 416-429 (2023). doi:10.1038/s41593-022-01240-0
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2-activati
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Weifeng Fan, Xiaojing Zhong, Qing Wu, Lihong Zhang, Zhenhao Yang, Yong Gu, Qi Guo, Xiaoyu Chen, Chen Yu, Kun Zhang, Wei Ding, Hualin Qi, Junli Zhao, Liming Zhang, Suhua Zhang, Jianying Niu
Publikováno v:
Kidney Research and Clinical Practice, Vol 43, Iss 3, Pp 358-368 (2024)
Background The correlation between hearing loss (HL) and physical performance in patients receiving maintenance hemodialysis (MHD) remains poorly investigated. This study explored the association between HL and physical performance in patients on MHD
Externí odkaz:
https://doaj.org/article/80afe5d388794fc684b6c606b7181f1d
Autor:
Wei Liu, Maoliang Zhang, Yi Liu, Lifeng Cui, Yuji Sano, Xiaocheng Zhou, Ying Li, Lihong Zhang, Yun-Chao Lang, Cong-Qiang Liu, Sheng Xu
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-11 (2024)
Abstract The active Himalayan-Tibetan orogen, where India underthrusts into Asia, is an important geological source of carbon dioxide (CO2) emission into Earth’s atmosphere. However, the extent to which Indian underthrusting could stimulate the mob
Externí odkaz:
https://doaj.org/article/909f8611072b4198ae088d6e73b4c5bc