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6-Heterocyclic carboxylic ester derivatives of gliotoxin lead to LSD1 inhibitors in gastric cancer cells

Autor: Lihong Shan, Zhaoxiang Li, Huabin Chen, Meng Ge, Yingying Sun, Ying Sun, Yaru Li, Hongyu Li, Ling Fu, Hongmin Liu

Publikováno v: Bioorganic chemistry. 131

Gliotoxin is a representative compound of the epipolythiodioxopiperazine (ETP) class of fungal metabolites. Histone Lysine Specific Demethylase 1 (LSD1) is highly expressed in a variety of cancers. Herein, a series of 6-heterocyclic carboxylic ester

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b02421ced9c72d22403817feb9a1de2
https://pubmed.ncbi.nlm.nih.gov/36508940

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Designed, synthesized and biological evaluation of proteolysis targeting chimeras (PROTACs) as AR degraders for prostate cancer treatment

Autor: Hang Xie, Rui-Hua Yang, Lihong Shan, Yu Ke, Ya-Lei Wang, Hong-Min Liu, Zi-Jun Zheng, Liang Jianjia, Zhi-Jia Wang, Chen Zhou, Ni Wang

Publikováno v: Bioorganicmedicinal chemistry. 45

As a continuation of our research on developing potent and potentially safe androgen receptor (AR) degrader, a series of novel proteolysis targeting chimeras (PROTACs) containing the phthalimide degrons with different linker were designed, synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bee2ef8ba38e6e64252aca49df423e
https://pubmed.ncbi.nlm.nih.gov/34364224

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Screening and pharmacodynamic evaluation of the antirespiratory syncytial virus activity of steroidal pyridine compounds in vitro and in vivo

Autor: Li Zhu, Duoduo Hou, Yingying Sun, Jieyu Fang, Yayun Tan, Lihong Shan, Zhenya Wang, Zichen Gu

Publikováno v: Journal of medical virologyREFERENCES. 93(6)

Respiratory syncytial virus (RSV) causes serious lower respiratory tract infections and there are currently no safer or more effective drugs available. It is important to find novel medications for RSV infection. A series of steroidal pyridines were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4133210a166d0b14b3f0269e5bba7564
https://pubmed.ncbi.nlm.nih.gov/33064304

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Tetramethylpyrazine Showed Therapeutic Effects on Sepsis-Induced Acute Lung Injury in Rats by Inhibiting Endoplasmic Reticulum Stress Protein Kinase RNA-Like Endoplasmic Reticulum Kinase (PERK) Signaling-Induced Apoptosis of Pulmonary Microvascular Endothelial Cells

Autor: Kaizhong Liu, Shu Zhang, Jiangfeng Tang, Wensheng Liu, Lihong Shan

Publikováno v: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

BACKGROUND Acute lung injury (ALI) is a life-threatening complication of sepsis. Tetramethylpyrazine (TMP) has been used in the clinical treatment of vascular diseases. The aim of this study was to investigate the therapeutic effects and possible inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8c1374c9eb1f7ea720e2a1e9602281
https://doi.org/10.12659/msm.908616

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Metal-Free Synthesis of (E)-Monofluoroenamine from 1-Sulfonyl-1,2,3-triazole and Et2O·BF3 via Stereospecific Fluorination of α-Diazoimine

Autor: Ze-Feng Xu, Lihong Shan, Haican Dai, Chuan-Ying Li

Publikováno v: Organic Letters. 20:1054-1057

A general, stereospecific, and straightforward method for the rapid preparation of functionalized (E)-monofluoroenamines is reported. Rather than transition metals (Rh, Ni, Pd, Cu, Ag, etc.), Et2O·BF3 was employed to promote the formation of α-diaz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e159cb67eb2682749708aa140152209f
https://doi.org/10.1021/acs.orglett.7b04014

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