Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lihong, Zhan"'
Autor:
Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.
Externí odkaz:
https://doaj.org/article/1f855da0da7c4c2995106bb45af63b8f
Autor:
Lihong Zhan, Li Fan, Lay Kodama, Peter Dongmin Sohn, Man Ying Wong, Gergey Alzaem Mousa, Yungui Zhou, Yaqiao Li, Li Gan
Publikováno v:
eLife, Vol 9 (2020)
Microglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse brains can survive without CSF1R signaling and reestablish the
Externí odkaz:
https://doaj.org/article/38de165a5edb4d8e822dcdefe18cdd9b
Autor:
Lihong Zhan, Grietje Krabbe, Fei Du, Ian Jones, Meredith C Reichert, Maria Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-Hyun Cho, Faten Sayed, Yaqiao Li, David Le, Yungui Zhou, Yin Shen, Brian West, Li Gan
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000134 (2019)
Microglia are resident immune cells that play critical roles in maintaining the normal physiology of the central nervous system (CNS). Remarkably, microglia have an intrinsic capacity to repopulate themselves after acute ablation. However, the underl
Externí odkaz:
https://doaj.org/article/20a6e03402384b01a796884e40f2c6d4
Autor:
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I. Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E. Pizzo, Rachel Prorok, Elliot Thomsen, Laura M. Bartos, Philipp Beumers, Anja Capell, Sonnet S. Davis, Lis de Weerd, Jason C. Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T. Kunte, Lea H. Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O. Torres, Hoang N. Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H. Suh, Robert G. Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y. Joy Yu Zuchero, Dolo Diaz, Mark S. Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J. Watts, Christian Haass, Joseph W. Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E. Sanchez, Kathryn M. Monroe
Publikováno v:
Nature neuroscience 26, 416-429 (2023). doi:10.1038/s41593-022-01240-0
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a1a80e71ec71d0d797c20ae600bdaa
https://doi.org/10.1038/s41593-022-01240-0
https://doi.org/10.1038/s41593-022-01240-0
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Yungui Zhou, Lihong Zhan, Ben A. Bahr, Sheng Ding, David Le, Maria Telpoukhovskaia, Min Xie, Jon Iker Etchegaray, Yaqiao Li, Faten A. Sayed, Matthew Bogyo, Li Gan, Kai Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Patients with frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have reduced levels of progranulin and exhibit dysregulation in inflammatory and lysosomal networks. Microglia produce high levels of progranulin, and reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b717edaa83f83d26f6fc4d526cda2c
http://link.springer.com/article/10.1038/s41598-020-70534-9
http://link.springer.com/article/10.1038/s41598-020-70534-9
Autor:
Nina M, Dräger, Sydney M, Sattler, Cindy Tzu-Ling, Huang, Olivia M, Teter, Kun, Leng, Sayed Hadi, Hashemi, Jason, Hong, Giovanni, Aviles, Claire D, Clelland, Lihong, Zhan, Joe C, Udeochu, Lay, Kodama, Andrew B, Singleton, Mike A, Nalls, Justin, Ichida, Michael E, Ward, Faraz, Faghri, Li, Gan, Martin, Kampmann
Publikováno v:
Nature neuroscience. 25(9)
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2d21f95b47547b29ccf967a5ceb7717
https://pubmed.ncbi.nlm.nih.gov/35953545
https://pubmed.ncbi.nlm.nih.gov/35953545
Autor:
Kun Leng, Michael E. Ward, Faraz Faghri, Justin K. Ichida, Li Gan, AB Singleton, Clelland Cd, Huang Ct, Martin Kampmann, Sattler Sm, Jason Hong, Draeger Nm, Sayed Hadi Hashemi, Teter Om, Mike A. Nalls, Lihong Zhan, Kodama L
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c734cf19c0bc8ab4d0a99ef72f1238b
https://doi.org/10.1101/2021.06.16.448639
https://doi.org/10.1101/2021.06.16.448639
Autor:
Chao Wang, Yaqiao Li, Lay Kodama, Li Fan, Bruce L. Miller, Carlo Condello, Lihong Zhan, Lea T. Grinberg, David Le, Sue-Ann Mok, Bangyan Liu, Jason E. Gestwicki, Marcus Y. Chin, Li Gan, Yungui Zhou, William W. Seeley
Activation of microglia, the brain’s innate immune cells, is a prominent pathological feature in tauopathies, including Alzheimer’s disease. How microglia activation contributes to tau toxicity remains largely unknown. Here we show that nuclear f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d36224b5351f3eaf619107ba55d7bb
https://doi.org/10.1101/2021.02.22.432272
https://doi.org/10.1101/2021.02.22.432272
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57214 (2013)
Cytosolic aggregation of the nuclear RNA-binding protein TDP-43 is a histopathologic signature of degenerating neurons in amyotrophic lateral sclerosis (ALS), and mutations in the TARDBP gene encoding TDP-43 cause dominantly inherited forms of this c
Externí odkaz:
https://doaj.org/article/c645b9604db14decae0770f39639484e