Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lih-Yun Hsu"'
Autor:
Yuqin Song, Ning Ding, Dok Hyun Yoon, John C. Reneau, Ryan A. Wilcox, Won Seog Kim, Youn H. Kim, Michael S. Khodadoust, Tatyana A. Feldman, Costas K. Yannakou, Pratyush Giri, Jonathan E Brammer, Lih-Yun Hsu, Hongwei Yuan, Erik Verner, Suresh Mahabhashyam, Richard A. Miller
Publikováno v:
Blood. 140:8857-8859
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd57e7c8e8243ec9b84e25567123f94f
https://doi.org/10.1182/blood-2022-159177
https://doi.org/10.1182/blood-2022-159177
Autor:
Lih-Yun Hsu, Rahul D. Pawar, Dan Li, Poorva Ghosh, Kevin Nguyen, Carlene Williams, Yuqin Song, Ning Ding, Erik Verner, Richard A. Miller
Publikováno v:
Cancer Research. 83:1813-1813
Interleukin 2 inducible T cell kinase (ITK) plays a role in both T cell receptor (TCR) signaling and T helper cell differentiation. ITK-/- mice exhibit defects in Th2 differentiation while retaining the ability to differentiate into Th1 cells that se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa2101fe43c36c6a58aa40effaa06aa4
https://doi.org/10.1158/1538-7445.am2023-1813
https://doi.org/10.1158/1538-7445.am2023-1813
Autor:
Eric Hansen, Lih-Yun Hsu, Debra A. Cheng, Julie Zikherman, Judith F. Ashouri, Marina Sirota, Arthur Weiss, Lisa L. Lattanza, Yiling Chen, Dmitry Rychkov, Steven Yu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 37
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 37
Significance How arthritis-causing T cells trigger rheumatoid arthritis (RA) is not understood since it is difficult to differentiate T cells activated by inflammation in arthritic joints from those activated through their T cell antigen receptor (TC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b3b92009ae4696c750baabc52dc45
https://doi.org/10.1073/pnas.1904271116
https://doi.org/10.1073/pnas.1904271116
Publikováno v:
The Journal of experimental medicine, vol 214, iss 3
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Hsu et al. show that a hypermorphic allele of Zap70, characterized by reduced autoinhibition, is associated with increased TCR signaling and triggers regulatory mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc1e914d8a5420e9832c154e7a08c03
https://escholarship.org/uc/item/5x92s2b3
https://escholarship.org/uc/item/5x92s2b3
Autor:
Lih-Yun Hsu, Emil H. Palacios, John Kuriyan, Arthur Weiss, Byron B. Au-Yeung, Susan E. Levin, Sebastian Deindl
Publikováno v:
Immunological Reviews. 228:41-57
The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement. The importance of ZAP-70 is evidenced by the severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2bed7a722fdf5db647afbf2f2acc45
https://doi.org/10.1111/j.1600-065x.2008.00753.x
https://doi.org/10.1111/j.1600-065x.2008.00753.x
Autor:
Ashouri, Judith F., Lih-Yun Hsu, Steven Yu, Rychkov, Dmitry, Yiling Chen, Cheng, Debra A., Sirota, Marina, Hansen, Erik, Lattanza, Lisa, Zikherman, Julie, Weiss, Arthur
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/10/2019, Vol. 116 Issue 37, p18517-18527, 11p
Publikováno v:
Cell. 118(1):19-29
Regulated gene rearrangement is thought to underlie allelic exclusion, the observation that an individual B cell expresses only a single immunoglobulin molecule. Previous data has implicated transcriptional activation of rearranging loci in the regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec9b42ca71e055f26e9344c0647480b
Publikováno v:
The Journal of Experimental Medicine
Mice deficient for the B cell–restricted transcription factor Pax5 show a defect in the VH to DJH rearrangement step of immunoglobulin heavy chain gene assembly even though the expression of the V(D)J recombinase is not diminished in Pax5−/− pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa30a83cf63448238b8de26d6ba6bf69
https://doi.org/10.1084/jem.20032249
https://doi.org/10.1084/jem.20032249
Autor:
Leonore A. Herzenberg, Mark S. Schlissel, Michael G. Anderson, Rachel M. Gerstein, Lih-Yun Hsu, Lisa A. Borghesi, Juli P. Miller, David Allman, Leonard A. Herzenberg
Publikováno v:
The Journal of Experimental Medicine
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initiation of V(D)J recombination at antigen receptor loci. However, little is known about when during hematopoietic development the V(D)J recombinase is fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228b6fdc61ebd5d278721dc71cb14511
https://doi.org/10.1084/jem.20031800
https://doi.org/10.1084/jem.20031800
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 193, iss 6
Van Der Loeff, IS; Hsu, LY; Saini, M; Weiss, A; & Seddon, B. (2014). Zap70 is essential for long-term survival of naive CD8 T cells. Journal of Immunology, 193(6), 2873-2880. doi: 10.4049/jimmunol.1400858. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6vd6673w
Van Der Loeff, IS; Hsu, LY; Saini, M; Weiss, A; & Seddon, B. (2014). Zap70 is essential for long-term survival of naive CD8 T cells. Journal of Immunology, 193(6), 2873-2880. doi: 10.4049/jimmunol.1400858. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6vd6673w
Survival of naive T cells requires engagement of TCR with self-peptide major histocompatibility Ags. The signaling pathways required to transmit this survival signal are poorly understood. In this study, we asked whether the tyrosine kinase Zap70 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84ab07e1c797bbe0ef8f297efc30475
https://escholarship.org/uc/item/6vd6673w
https://escholarship.org/uc/item/6vd6673w