Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Lih-Shen Chin"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract DJ-1 is a ubiquitously expressed protein that protects cells from stress through its conversion into an active protease. Recent work found that the active form of DJ-1 was induced in the ischemic heart as an endogenous mechanism to attenuate
Externí odkaz:
https://doaj.org/article/edca3d41b4134b81ac974e626b3347aa
Publikováno v:
Bio-Protocol, Vol 11, Iss 12 (2021)
Protein N-glycosylation plays a vital role in diverse cellular processes, and dysregulated N-glycosylation is implicated in a variety of human diseases including neurodegenerative disorders and cancer. With recent advances in high-resolution mass spe
Externí odkaz:
https://doaj.org/article/4287af10959a450da91cd48ca3ec70e0
Autor:
Cheng Ma, Hong-Yuan Tsai, Qi Zhang, Lakmini Senavirathna, Lian Li, Lih-Shen Chin, Ru Chen, Sheng Pan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8251 (2022)
As a well-known glycolysis inhibitor for anticancer treatment, 2-Deoxy-D-glucose (2DG) inhibits the growth and survival of cancer cells by interfering with the ATP produced by the metabolism of D-glucose. In addition, 2DG inhibits protein glycosylati
Externí odkaz:
https://doaj.org/article/5331aea9d83e4335b4ff9b50dc3ef69d
Autor:
Yuuki Shimizu, Chad K. Nicholson, Rohini Polavarapu, Yvanna Pantner, Ahsan Husain, Nawazish Naqvi, Lih‐Shen Chin, Lian Li, John W. Calvert
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 4 (2020)
Background DJ‐1 is a ubiquitously expressed protein typically associated with the development of early onset Parkinson disease. Recent data suggest that it also plays a role in the cellular response to stress. Here, we sought to determine the role
Externí odkaz:
https://doaj.org/article/454ddee5519d4b83b7cd5d6673f04554
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-19 (2018)
Abstract Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a systems-level study of disease-associated proteome ch
Externí odkaz:
https://doaj.org/article/5888454dc6ab45978910ccc7ca7cb301
Publikováno v:
Protein & Cell, Vol 9, Iss 8, Pp 693-716 (2017)
ABSTRACT Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson’s disease, dystonia, and epilepsy. Genetic studies have identified a homozygous truncation mutation
Externí odkaz:
https://doaj.org/article/d11ef78e0050489fa6822dde43d47628
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1, aka PGP9.5) is an abundant, neuronal deubiquitinating enzyme that has also been suggested to possess E3 ubiquitin-protein ligase activity and/or stabilize ubiquitin monomers in vivo. Recent evidence i
Externí odkaz:
https://doaj.org/article/0f00193023364801b521fb9e165c74f4
Publikováno v:
PLoS Biology, Vol 5, Iss 7, p e172 (2007)
Mutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been reported, and the mechanism by which PINK1 mutations lead to neurodegeneration is unkno
Externí odkaz:
https://doaj.org/article/2e06a98d00c0430f82af4d2e76d6400d
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
DJ-1 is a ubiquitously expressed protein that protects cells from stress through its conversion into an active protease. Recent work found that the active form of DJ-1 was induced in the ischemic heart as an endogenous mechanism to attenuate glycativ
Publikováno v:
Bio Protoc
Protein N-glycosylation plays a vital role in diverse cellular processes, and dysregulated N-glycosylation is implicated in a variety of human diseases including neurodegenerative disorders and cancer. With recent advances in high-resolution mass spe