Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Liguo Chi"'
Autor:
Wenjing Liang, Shakti Sagar, Rishith Ravindran, Rita H. Najor, Justin M. Quiles, Liguo Chi, Rachel Y. Diao, Benjamin P. Woodall, Leonardo J. Leon, Erika Zumaya, Jason Duran, David M. Cauvi, Antonio De Maio, Eric D. Adler, Åsa B. Gustafsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degrada
Externí odkaz:
https://doaj.org/article/02588d67bd4f4beeb14563fa5e5e84d7
Publikováno v:
Circulation Research. 131
Cardiac myocytes require large amounts of energy generated by mitochondria to sustain contraction, and there is a strong link between mitochondrial dysfunction and heart disease. Defective mitochondria are less efficient at generating ATP, produce ex
Publikováno v:
Circulation Research. 131
Alpha-B-crystallin (CryAB) is an abundant molecular chaperone comprising nearly 5% of total cardiac mass. While predominately cytosolic, some studies note mitochondrial translocation of CryAB during stress. The autosomal dominant R120G mutation leads
Publikováno v:
Circulation Research. 131
Cardiac myocytes require large amounts of energy supplied by mitochondrial oxidative phosphorylation to sustain contractile function in heart. Because mitochondria can turn into death-promoting organelles, cells have developed defense mechanisms agai
Autor:
Ouyang Kunfu, Anh T. Nguyen, Wei Feng, Siting Zhu, Liguo Chi, Leonardo J Leon, Sylvia M. Evans, Simone Spinozzi, Frédéric M. Vaz, Yi Zhou, Åsa B. Gustafsson, Mason Zhu, Ying Shen, Changming Tan, Yusu Gu, Zee Chen, Xi Fang, Xiaohong Wang
Publikováno v:
Circulation. Heart failure, 708-721. Lippincott Williams and Wilkins
STARTPAGE=708;ENDPAGE=721;ISSN=1941-3289;TITLE=Circulation. Heart failure
Circ Heart Fail
STARTPAGE=708;ENDPAGE=721;ISSN=1941-3289;TITLE=Circulation. Heart failure
Circ Heart Fail
Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafazzin ( TAZ ), encoding a mitochondrial acyltransferase required for cardiolipin remodeling. Despite r
Autor:
Michael Holinstat, Anuli C. Anyanwu, Raymond Zhao, J. Michelle Kahlenberg, Sharon Koonse, Hui Liao, Yogendra Kanthi, Benjamin E. Tourdot, Benjamin N. Jacobs, Scott H. Visovatti, Srilakshmi Yalavarthi, Alison L. Banka, Liguo Chi, Vinita Yadav, David J. Pinsky, Jason S. Knight
Publikováno v:
Journal of Clinical Investigation. 129:2872-2877
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of evidence ind
Autor:
Vinita, Yadav, Liguo, Chi, Raymond, Zhao, Benjamin E, Tourdot, Srilakshmi, Yalavarthi, Benjamin N, Jacobs, Alison, Banka, Hui, Liao, Sharon, Koonse, Anuli C, Anyanwu, Scott H, Visovatti, Michael A, Holinstat, J Michelle, Kahlenberg, Jason S, Knight, David J, Pinsky, Yogendra, Kanthi
Publikováno v:
The Journal of clinical investigation. 129(7)
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis, is the third most common cause of cardiovascular mortality, however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of evidence in
Autor:
Yogendra Kanthi, Tekashi Mimura, Raymond Zhao, Keigo Fukase, Matthew C. Hyman, Vinita Yadav, David J. Pinsky, Hui Liao, Saabir Kaskar, Karl C. Desch, Liguo Chi, Martin M. Gruca, Thomas W. Wakefield, Anuli C. Anyanwu, Hussein Sheikh-Aden
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39
Objective— Leukocyte flux contributes to thrombus formation in deep veins under pathological conditions, but mechanisms that inhibit venous thrombosis are incompletely understood. Ectonucleotide di(tri)phosphohydrolase 1 ( ENTPD1 or Cd39 ), an ecto
Autor:
Aliya Zeng, Haiyun Ling, Sridharan Rajamani, Ryoko Hirakawa, Luiz Belardinelli, Liguo Chi, Arvinder Dhalla
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H1313-H1320
Late Na+ current ( INaL) is enhanced in myocytes of animals with chronic heart failure and patients with hypertrophic cardiomyopathy. To define the role of INaL in diastolic heart failure, the effects of GS-458967 (GS-967), a potent INaL inhibitor on
Autor:
Siting Zhu, Ze’e Chen, Mason Zhu, Ying Shen, Leon, Leonardo J., Liguo Chi, Spinozzi, Simone, Changming Tan, Yusu Gu, Anh Nguyen, Yi Zhou, Wei Feng, Vaz, Frédéric M., Xiaohong Wang, Gustafsson, Asa B., Evans, Sylvia M., Ouyang Kunfu, Xi Fang
Publikováno v:
Circulation: Heart Failure; Jun2021, Vol. 14 Issue 6, p708-721, 14p