Critical Review of the Use of Second-Generation Antipsychotics in Obsessive–Compulsive and Related Disorders

Autor: Dongmi Kim, Ligia Westrich, Julie Kalabalik, Nicole L. Ryba

Publikováno v: Drugs in R&D

Currently, all second-generation antipsychotics are approved for schizophrenia. Many are also approved for bipolar disorder, with some also approved as adjunctive treatment for depression and autism-related irritability. Second-generation antipsychot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef39cb0bf2a6bca820a50d9796a70ee
https://doi.org/10.1007/s40268-018-0246-8

Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Autor: Christoffer Bundgaard, Ligia Westrich, Arne Mørk, Benny Bang-Andersen, T. Bryan Stensbøl, Christina W. Fischer, Samuel I. Miller, Sandra Hogg, Nico Liebenberg, Gregers Wegener, Alan L. Pehrson, Connie Sanchez, H. Zhong, Lise T. Brennum, A.B. Lassen, N. J. Boyle, S. Møller Nielsen

Publikováno v: Mork, A, Pehrson, A, Tottrup Brennum, L, Moller Nielsen, S, Zhong, H, Lassen, A B, Miller, S, Westrich, L, Boyle, N J, Sanchez, C, Fischer, C, Liebenberg, N, Wegener, G, Bundgaard, C, Hogg, S, Bang-Andersen, B & Bryan Stensbol, T 2012, ' Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder ', Journal of Pharmacology and Experimental Therapeutics, vol. 340, no. 3, pp. 666-675 . https://doi.org/10.1124/jpet.111.189068

1-[2-(2,4-Dimethylphenyl-sulfanyl)-phenyl]-piperazine (Lu AA21004) is a human (h) serotonin (5-HT)(3A) receptor antagonist (K(i) = 3.7 nM), h5-HT(7) receptor antagonist (K(i) = 19 nM), h5-HT(1B) receptor partial agonist (K(i) = 33 nM), h5-HT(1A) rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723937f4dcc13fe06f59dd1b3127c678
https://doi.org/10.1124/jpet.111.189068

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

Autor: Steven C. Leiser, Ligia Westrich, Alan L. Pehrson, Deborah Iglesias-Bregna, Connie Sanchez

Publikováno v: Journal of Psychopharmacology (Oxford, England)

Antidepressants often disrupt sleep. Vortioxetine, a multimodal antidepressant acting through serotonin (5-HT) transporter (SERT) inhibition, 5-HT3, 5-HT7 and 5-HT1D receptor antagonism, 5-HT1B receptor partial agonism, and 5-HT1A receptor agonism, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe45d4f87e7922f4680b31338f76dbb
https://pubmed.ncbi.nlm.nih.gov/26174134

The effects of combining serotonin reuptake inhibition and 5-HT7 receptor blockade on circadian rhythm regulation in rodents

Autor: Connie Sanchez, Jeffrey Sprouse, Ligia Westrich

Publikováno v: Physiologybehavior.

Disruption of circadian rhythms may lead to mood disorders. The present study investigated the potential therapeutic utility of combining a 5-HT7 antagonist with a selective serotonin (5-HT) reuptake inhibitor (SSRI), the standard of care in depressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63e0d83061670e79a8878e200782c99
https://pubmed.ncbi.nlm.nih.gov/23276605

Development of tolerance in D3 dopamine receptor signaling is accompanied by distinct changes in receptor conformation

Autor: Sara Gil-Mast, Eldo V. Kuzhikandathil, Sandhya Kortagere, Ligia Westrich

Publikováno v: Biochemical pharmacology. 79(6)

The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3 receptor tolerance property is not mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0932f14a24d2435b74f7596197f1c0b
https://pubmed.ncbi.nlm.nih.gov/19879251