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The glutamine 27 β-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families

Autor: Jane Dewar, Harvey Jf, J Wilkinson, Holgate St, Liggett Sb, N. S. Thomas, Pietro Liò, Morton N, Ian P. Hall, Iolo Doull, Amanda Wheatley

Publikováno v: Journal of Allergy and Clinical Immunology. 100:261-265

Background: The β 2 -adrenoceptor polymorphisms occurring at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamate) are known to be functionally relevant and also disease-modifying in subjects with asthma. However, the contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98573c65fa1afb5de890fd2ac5bc62af
https://doi.org/10.1016/s0091-6749(97)70234-3

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β2-agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D

Autor: Trian, T, Burgess, JK, Niimi, K, Moir, LM, Ge, Q, Berger, P, Liggett, SB, Black, JL, Oliver, BG

Background and Objective: Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::0a3b9a9f0fb9531cb7d7fb1259bc0e0f
https://hdl.handle.net/10453/121786

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An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta(2)-adrenergic receptor stimulation

Autor: Small, KM, Brown, KM, Theiss, CT, Seman, CA, Weiss, ST, Liggett, SB

Publikováno v: Pharmacogenetics, 13(9), 535-541

Adenylyl cyclase (AC) mediates signalling following activation of G(alphas)-coupled receptors such as the beta(2)- adrenergic receptor (PAR). Genetic variation in the receptor component of this pathway can alter signal transduction and the response t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::96d2da7d57be138afc4b04f487957343
https://research.rug.nl/en/publications/b559ec27-3a97-4bb5-9d06-7eebeb3f1d11

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Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma

Publikováno v: Israel, E; Drazen, JM; Liggett, SB; Boushey, HA; Cherniack, RM; Chinchilli, VM; et al.(2001). Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.. International archives of allergy and immunology, 124(1-3), 183-186. doi: 10.1159/000053705. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3k75x163

Regular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9c5bd04321499115d5a65fc0651f17ca
http://www.escholarship.org/uc/item/3k75x163

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The effect of polymorphisms of the β2-adrenergic receptor on the response to regular use of albuterol in asthma

Autor: Israel, E, Drazen, JM, Liggett, SB, Boushey, HA, Cherniack, RM, Chinchilli, VM, Cooper, DM, Fahy, JV, Fish, JE, Ford, JG

Publikováno v: Israel, E; Drazen, JM; Liggett, SB; Boushey, HA; Cherniack, RM; Chinchilli, VM; et al.(2000). The effect of polymorphisms of the β2-adrenergic receptor on the response to regular use of albuterol in asthma. American Journal of Respiratory and Critical Care Medicine, 162(1), 75-80. doi: 10.1164/ajrccm.162.1.9907092. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0ph8b9jj

Inhaled β-adrenergic agonists are the most commonly used medications for the treatment of asthma although there is evidence that regular use may produce adverse effects in some patients. Polymorphisms of the β2- adrenergic receptor (β2-AR) can aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f11ae39a18e1318df68ead6a05531e1a
http://www.escholarship.org/uc/item/0ph8b9jj

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