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Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

Autor: Nicol, Marlynne Q., Campbell, Gillian M., Shaw, Darren J., Dransfield, Ian, Ligertwood, Yvonne, Beard, Philippa M., Nash, Anthony A., Dutia, Bernadette M.

Publikováno v: Virology

IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR-/-) at a dose which caused severe disease in wild type 129

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::147ada0c0b0b75b3c146b02a84dd7d64
http://europepmc.org/articles/PMC6286381

Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

Autor: Turnbull, Matthew L, Wise, Helen M, Nicol, Marlynne Q, Smith, Nikki, Dunfee, Rebecca L, Beard, Philippa M, Jagger, Brett W, Ligertwood, Yvonne, Hardisty, Gareth R, Xiao, Haixia, Benton, Donald J, Coburn, Alice M, Paulo, Joao A, Gygi, Steven P, McCauley, John W, Taubenberger, Jeffery K, Lycett, Samantha J, Weekes, Michael P, Dutia, Bernadette M, Digard, Paul

UNLABELLED: Two alleles of segment 8 (NS) circulate in nonchiropteran influenza A viruses. The A allele is found in avian and mammalian viruses, but the B allele is viewed as being almost exclusively found in avian viruses. This might reflect the fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::f776285e305e6f81a7edca984259a206
https://www.repository.cam.ac.uk/handle/1810/260668

The Role of the B-Allele of the Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

Autor: Turnbull, Matthew, Wise, Helen, Nicol, Marlynne, Smith, Nikki, Dunfee, Rebecca L, Beard, Philippa, Jagger, Brett W, Ligertwood, Yvonne, Hardisty, Gareth, Xiao, Haixia, Benton, Donald J, Coburn, Alice M, Paulo, Joao A, Gygi, Steven P, McCauley, John W, Taubenberger, Jeffery K., Lycett, Samantha, Weekes, Michael P, Dutia, Bernadette, Digard, Paul

Publikováno v: Turnbull, M, Wise, H, Nicol, M, Smith, N, Dunfee, R L, Beard, P, Jagger, B W, Ligertwood, Y, Hardisty, G, Xiao, H, Benton, D J, Coburn, A M, Paulo, J A, Gygi, S P, McCauley, J W, Taubenberger, J K, Lycett, S, Weekes, M P, Dutia, B & Digard, P 2016, ' The Role of the B-Allele of the Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity ', Journal of Virology, vol. 90, no. 20, pp. 9263-9284 . https://doi.org/10.1128/JVI.01205-16

Two ‘alleles' of segment 8 (NS) circulate in non-chiropteran influenza A viruses. The A-allele is found in avian and mammalian viruses, but the B-allele is viewed as almost exclusively avian. This might reflect that one or both of its encoded prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::98d192b58d4dda3986c741f97b1864af
https://www.pure.ed.ac.uk/ws/files/28306130/J._Virol._2016_Turnbull_9263_84.pdf

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