Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Ligand-based pharmacophore"'
Publikováno v:
Journal of HerbMed Pharmacology, Vol 13, Iss 2, Pp 308-323 (2024)
Introduction: Over 422 million people worldwide suffer from diabetes, causing 1.5 million fatalities annually. The existing medications have shortcomings, including poor glucose control and adverse effects. The present study aimed to create possible
Externí odkaz:
https://doaj.org/article/2599fcc0aba14475aabbc9c6be307587
Autor:
Abeer H. A. Abdelhafiz, Rabah A. T. Serya, Deena S. Lasheen, Nessa Wang, Mansour Sobeh, Michael Wink, Khaled A. M. Abouzid
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2710-2724 (2022)
Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In this study, certain
Externí odkaz:
https://doaj.org/article/57eeea20c5b242c7b876f7be7406cf6f
Akademický článek
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Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100752- (2023)
Non-small-cell lung cancer (NSCLC) accounts for 85 % of lung cancer cases and is the leading cause of mortality globally. Anaplastic lymphoma kinase (ALK) has been identified as an NSCLC mutational cancer mediator. Many additional ALK inhibitors are
Externí odkaz:
https://doaj.org/article/91a6ee06c22f4553b71b7aab75e0e968
Publikováno v:
Informatics in Medicine Unlocked, Vol 32, Iss , Pp 101063- (2022)
Cardiovascular diseases (CVDs) are the leading causes of death, morbidity, and health expenses in developed and developing countries. Hyperlipidemia is the increase in plasma lipids and represents one of the main factors leading to CVDs. The 3-hydrox
Externí odkaz:
https://doaj.org/article/d8df29a1ffab4af58665c86eae7ac589
Autor:
Mohammad Habibur Rahman Molla, Mohammed Othman Aljahdali, Md Afsar Ahmed Sumon, Amer H. Asseri, Hisham N. Altayb, Md. Shafiqul Islam, Ahad Amer Alsaiari, F. A. Dain Md Opo, Nushrat Jahan, Foysal Ahammad, Farhan Mohammad
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 120 (2023)
Pancreatic cancer is a very deadly disease with a 5-year survival rate, making it one of the leading causes of cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) is a ubiquitously expressed protein in pancreatic cancer. FAK, a tyrosine ki
Externí odkaz:
https://doaj.org/article/b28373d3134e498dac5a28e884015a7d
Autor:
Serena Vittorio, Ilenia Adornato, Rosaria Gitto, Samuel Peña-Díaz, Salvador Ventura, Laura De Luca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1727-1735 (2020)
Parkinson’s disease is one of the most common neurodegenerative disorders in elderly age. One of the mechanisms involved in the neurodegeneration appears related to the aggregation of the presynaptic protein alpha synuclein (α-syn) into toxic olig
Externí odkaz:
https://doaj.org/article/8e22f912610347c8ba292a3ad609a7b1
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 646 (2022)
Computer-aided drug discovery techniques reduce the time and the costs needed to develop novel drugs. Their relevance becomes more and more evident with the needs due to health emergencies as well as to the diffusion of personalized medicine. Pharmac
Externí odkaz:
https://doaj.org/article/8a7c224795c64d7481535b3146f8d740
Akademický článek
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Akademický článek
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