Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Ligand discovery"'
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100174- (2024)
Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent
Externí odkaz:
https://doaj.org/article/14dcede2a25b44e698c22c77b0bfd532
Autor:
Vikrant Kumar, Puneeth Kumar Chunchagatta Lakshman, Thazhe Kootteri Prasad, Kavyashree Manjunath, Sneha Bairy, Akshaya S. Vasu, B. Ganavi, Subbarao Jasti, Neelagandan Kamariah
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23864- (2024)
Target-based discovery of first-in-class therapeutics demands an in-depth understanding of the molecular mechanisms underlying human diseases. Precise measurements of cellular and biochemical activities are critical to gain mechanistic knowledge of b
Externí odkaz:
https://doaj.org/article/db664869fa4c445ba01299e12ca67ed2
Akademický článek
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Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract The thermal shift assay (TSA)—also known as differential scanning fluorimetry (DSF), thermofluor, and Tm shift—is one of the most popular biophysical screening techniques used in fragment-based ligand discovery (FBLD) to detect protein
Externí odkaz:
https://doaj.org/article/716f45629e2b4f94b161dcee7038bf05
Diverse Sensory Repertoire of Paralogous Chemoreceptors Tlp2, Tlp3, and Tlp4 in Campylobacter jejuni
Autor:
Taha, Bassam A. Elgamoudi, Ekaterina P. Andrianova, Thomas Haselhorst, Christopher J. Day, Lauren E. Hartley-Tassell, Rebecca M. King, Tahria Najnin, Igor B. Zhulin, Victoria Korolik
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Campylobacter jejuni responds to extracellular stimuli via transducer-like chemoreceptors (Tlps). Here, we describe receptor-ligand interactions of a unique paralogue family of dCache_1 (double Calcium channels and chemotaxis) chemoreceptors
Externí odkaz:
https://doaj.org/article/00194fa2e5ad4d1288c5e6247486085e
Akademický článek
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Autor:
Kevin S. Johnson, Bassam A. Elgamoudi, Freda E.-C. Jen, Christopher J. Day, Emily Goers Sweeney, Megan L. Pryce, Karen Guillemin, Thomas Haselhorst, Victoria Korolik, Karen M. Ottemann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The Helicobacter pylori chemoreceptor TlpA plays a role in dampening host inflammation during chronic stomach colonization. TlpA has a periplasmic dCache_1 domain, a structure that is capable of sensing many ligands; however, the only charac
Externí odkaz:
https://doaj.org/article/958587dd065b4f2d967bac45ac018790
Autor:
Korczynska, Magdalena, Clark, Mary J., Valant, Celine, Xu, Jun, Von Moo, Ee, Albold, Sabine, Weiss, Dahlia R., Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C., Lyda, Brent R., May, Lauren T., Baltos, Jo-Anne, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur, Shoichet, Brian K., Sunahara, Roger K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Mar 01. 115(10), E2419-E2428.
Externí odkaz:
https://www.jstor.org/stable/26507907
Autor:
Claire Colas
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
SLC transporters are emerging key drug targets. One important step for drug development is the profound understanding of the structural determinants defining the substrate selectivity of each transporter. Recently, the improvement of computational po
Externí odkaz:
https://doaj.org/article/464397495a794a18b8e1dff644b4abe1
Autor:
Romain Galy, Stéphanie Ballereau, Yves Génisson, Lionel Mourey, Jean-Christophe Plaquevent, Laurent Maveyraud
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1282 (2021)
The mycolic acid biosynthetic pathway represents a promising source of pharmacological targets in the fight against tuberculosis. In Mycobacterium tuberculosis, mycolic acids are subject to specific chemical modifications introduced by a set of eight
Externí odkaz:
https://doaj.org/article/869c4c95e0134e7ba56dcb8fa892eb3e