Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Ligand <Biochemie>"'
Autor:
Drakopoulos, Antonios
Opioid receptors (ORs) are among the most intensively studied members of the G protein-coupled receptor (GPCR) family due to their important role in pain management and their involvement in psychological and neurological disorders. However, currently
Autor:
Volpato, Daniela
The past decades have witnessed the development of new pharmaceutical compounds that modulate receptor function by targeting allosteric sites. Allosteric sites are, by definition, domains topographically distinct from the orthosteric binding pocket w
Autor:
Volpato, Daniela
The past decades have witnessed the development of new pharmaceutical compounds that modulate receptor function by targeting allosteric sites. Allosteric sites are, by definition, domains topographically distinct from the orthosteric binding pocket w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______713::b5aa0009a1cbe91eea5cb45328c2cf89
https://doi.org/10.25972/OPUS-24881
https://doi.org/10.25972/OPUS-24881
Autor:
Riad, Noura
GPCRs, particularly muscarinic receptors (mAChRs), are significant therapeutic targets in many physiological conditions. The significance of dualsteric hybrids selectively targeting mAChR subtypes is their great advantage in avoiding undesired side e
Autor:
Riad, Noura
GPCRs, particularly muscarinic receptors (mAChRs), are significant therapeutic targets in many physiological conditions. The significance of dualsteric hybrids selectively targeting mAChR subtypes is their great advantage in avoiding undesired side e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7869ee832ae690d515d649bbc7b10a
Autor:
Schöpel, Miriam (M. Sc.)
Die Interaktion von Proteinen mit organischen Molekülen ist essentiell für die Zell-Signaltransduktion, da diese auf eine dynamische Anpassung an Umweltfaktoren angewiesen ist. Zusätzlich bieten Protein-Ligand-Interaktionen die Möglichkeit medizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3579::86c25524923d002665fca2a7c9e74901
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/5567
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/5567
Autor:
Dolles, Dominik
While life expectancy increases worldwide, treatment of neurodegenerative diseases such as AD becomes a major task for industrial and academic research. Currently, a treatment of AD is only symptomatical and limited to an early stage of the disease b
Autor:
Dolles, Dominik
While life expectancy increases worldwide, treatment of neurodegenerative diseases such as AD becomes a major task for industrial and academic research. Currently, a treatment of AD is only symptomatical and limited to an early stage of the disease b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______713::1f5de20a908d559a0c700569335b295b
https://opus.bibliothek.uni-wuerzburg.de/files/16344/Dolles_Dominik_Development_of_Hybrid_GPCR_Ligands.pdf
https://opus.bibliothek.uni-wuerzburg.de/files/16344/Dolles_Dominik_Development_of_Hybrid_GPCR_Ligands.pdf
G‐Protein‐gekoppelte Rezeptoren dienen der Wahrnehmung von extrazellulären Reizen wie z.B. Licht oder kleinen organischen Molekülen. Im Fokus dieser Arbeit stehen der \(\beta_2\)AR und Melanopsin. Ziel war die Charakterisierung beider GPCRs hin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3579::72ef4073fe0d64f1beb2ae9dc4a81b8a
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/5130/diss.pdf
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/5130/diss.pdf
Synthesis of Dualsteric Ligands for Muscarinic Acetylcholine Receptors and Cholinesterase Inhibitors
Autor:
Messerer, Regina
The study is dealing with the synthesis and pharmacological investigation of newly designed dualsteric ligands of muscarinic acetylcholine receptors belonging to the superfamily of G protein-coupled receptors. Such bipharmacophoric ligands combine th