Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Liga Zvejniece"'
Autor:
Edgars Liepinsh, Baiba Svalbe, Gundega Stelfa, Solveiga Grinberga, Liga Zvejniece, Helgi B. Schiöth, Maija Dambrova
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-5 (2023)
Abstract Deletion of exon 2 of the trimethyllysine hydroxylase epsilon (TMLHE) gene was identified in probands with autism spectrum disorder (ASD). TMLHE encodes the first enzyme in carnitine biosynthesis, N6-trimethyllysine dioxygenase (TMLD). Resea
Externí odkaz:
https://doaj.org/article/888378238f98412c8fc26df3fd5b663f
Autor:
Liga Zvejniece, Baiba Svalbe, Edijs Vavers, Melita Ozola, Solveiga Grinberga, Baiba Gukalova, Eduards Sevostjanovs, Edgars Liepinsh, Maija Dambrova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115803- (2023)
Long-chain acylcarnitines (LCACs) are intermediates of fatty acid oxidation and are known to exert detrimental effects on mitochondria. This study aimed to test whether lowering LCAC levels with the anti-ischemia compound 4-[ethyl(dimethyl)ammonio]bu
Externí odkaz:
https://doaj.org/article/3f0ea55ad0d343ed96f7ef8b1fb33f5f
Publikováno v:
Pharmacological Research, Vol 191, Iss , Pp 106771- (2023)
Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R ligands are underway testing therapies for the treatment of drug
Externí odkaz:
https://doaj.org/article/fcee1aaa25db4baa8c677bd6ad2d9fd1
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
As traumatic brain injury (TBI) is one of the major causes of permanent disability, there is increasing interest in the long-term outcome of TBI. While motor deficits, cognitive impairment and longer-term risks of neurodegenerative disease are well-e
Externí odkaz:
https://doaj.org/article/1c9a22f7d8b1477b921fe750ed9ff516
Autor:
Sergei Kopanchuk, Edijs Vavers, Santa Veiksina, Kadri Ligi, Liga Zvejniece, Maija Dambrova, Ago Rinken
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268563 (2022)
Sigma-1 receptor (Sig1R) is an endoplasmic reticulum (ER)-related membrane protein, that forms heteromers with other cellular proteins. As the mechanism of action of this chaperone protein remains unclear, the aim of the present study was to detect a
Externí odkaz:
https://doaj.org/article/d7b5711de27e439cbc690a993924147d
Autor:
Baiba Svalbe, Baiba Zvejniece, Gundega Stelfa, Karlis Vilks, Edijs Vavers, José Miguel Vela, Maija Dambrova, Liga Zvejniece
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1572 (2022)
Sigma-1 receptor (Sig1R) has been proposed as a therapeutic target for neurological, neurodegenerative, and psychiatric disorders, including depression and anxiety. Identifying metabolites that are affected by Sig1R absence and cross-referencing them
Externí odkaz:
https://doaj.org/article/4732e11896264421963d18e2bf0d429e
Autor:
Edijs Vavers, Baiba Zvejniece, Gundega Stelfa, Baiba Svalbe, Karlis Vilks, Einars Kupats, Rudolfs Mezapuke, Lasma Lauberte, Maija Dambrova, Liga Zvejniece
Publikováno v:
Neurobiology of Disease, Vol 150, Iss , Pp 105244- (2021)
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute a
Externí odkaz:
https://doaj.org/article/1cc4f9f487ae4ef98baf5b2c15b14830
Autor:
Baiba Svalbe, Solveiga Grinberga, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Eduards Sevostjanovs, Maija Dambrova, Liga Zvejniece
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
MK-801, a N-methyl-d-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentratio
Externí odkaz:
https://doaj.org/article/51097e3a74f446119970aa7496ac07d7
Autor:
Gundega Stelfa, Edijs Vavers, Baiba Svalbe, Rinalds Serzants, Anna Miteniece, Lasma Lauberte, Solveiga Grinberga, Baiba Gukalova, Maija Dambrova, Liga Zvejniece
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11611 (2021)
Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral d
Externí odkaz:
https://doaj.org/article/70d253feb31247a8af31dba787ef2f8e
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Allosteric modulators of sigma-1 receptor (Sig1R) are described as compounds that can increase the activity of some Sig1R ligands that compete with (+)-pentazocine, one of the classic prototypical ligands that binds to the orthosteric Sig1R binding s
Externí odkaz:
https://doaj.org/article/326854e87b7f4f978ece355ff7283c14