Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Liezl Gibhard"'
Autor:
Daniel J. Watson, Lizahn Laing, Richard M. Beteck, Liezl Gibhard, Richard K. Haynes, Lubbe Wiesner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The emergence of Plasmodium falciparum (Pf) parasite strains tolerant of the artemisinin component and resistant to the other drug component in artemisinin combination therapies (ACTs) used for treatment now markedly complicates malaria control. Thus
Externí odkaz:
https://doaj.org/article/0fa9857392ad4a1886dbda6556e86f19
Autor:
Liezl Gibhard, Dina Coertzen, Janette Reader, Mariëtte E. van der Watt, Lyn-Marie Birkholtz, Ho Ning Wong, Kevin T. Batty, Richard K. Haynes, Lubbe Wiesner
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2066 (2021)
Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable s
Externí odkaz:
https://doaj.org/article/961b961512034a18beeab2e2a9be0ff9
Autor:
Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 65:16695-16715
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
The translation of a preclinical antimalarial drug development candidate to the clinical phases should be supported by rational human dose selection. A model-informed strategy based on preclinical data, which incorporates pharmacokinetic–pharmacody
Autor:
William M.R. Matshe, Lesego L. Tshweu, Sindisiwe Mvango, Zamani E.D. Cele, Avashnee S. Chetty, Lynne A. Pilcher, Ibukun M. Famuyide, Lyndy J. McGaw, Dale Taylor, Liezl Gibhard, Gregory S. Basarab, Mohammed O. Balogun
Publikováno v:
Macromolecular Bioscience. 23
Autor:
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale
Publikováno v:
Science Translational Medicine. 14
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and i
Autor:
Constance M. Korkor, Kelly Chibale, Godwin Akpeko Dziwornu, Sergio Wittlin, Dina Coertzen, Cleavon K Cloete, Meta Leshabane, Mathew Njoroge, Janette Reader, Nina Lawrence, Lyn-Marie Birkholtz, Liezl Gibhard, Mariëtte van der Watt
Publikováno v:
Journal of Medicinal Chemistry. 64:5198-5215
A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure-activity relationship studies revealed
Autor:
Gregory S. Basarab, Sandeep Ghorpade, Liezl Gibhard, Rudolf Mueller, Mathew Njoroge, Nashied Peton, Preshendren Govender, Lisa M. Massoudi, Gregory Thomas Robertson, Anne J. Lenaerts, Helena Ingrid Boshoff, Douglas Joerss, Tanya Parish, Thomas F. Durand-Reville, Manos Perros, Vinayak Singh, Kelly Chibale
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Described here is a series of spiropyrimidinetrione (SPT) compounds with activity against Mycobacterium tuberculosis through inhibition of DNA gyrase. The SPT class operates via a novel mode of inhibition, which involves Mg 2+ -independent stabilizat
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Autor:
Lyn-Marie Birkholtz, Liezl Gibhard, Lubbe Wiesner, Richard K. Haynes, Ho Ning Wong, Kevin T Batty, Janette Reader, Mariëtte van der Watt, Dina Coertzen
Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e29cbfca9c36e1c832a7602149756cce
https://doi.org/10.20944/preprints202111.0072.v1
https://doi.org/10.20944/preprints202111.0072.v1