Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Liezl E. Francisco"'
Autor:
Tressie A. Posey, Joan Jacob, Ashlyn Parkhurst, Shraddha Subramanian, Liezl E. Francisco, Zhengdong Liang, Kendra S. Carmon
Publikováno v:
Molecular Cancer Therapeutics. 22:667-678
Leucine-rich repeat-containing, G protein-coupled receptor 5 (LGR5) is highly expressed in colorectal cancer and cancer stem cells (CSCs) that play important roles in tumor initiation, progression, and metastasis. Loss of LGR5 has been shown to enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e14901eed9e01d285d6f295dc99c889
https://doi.org/10.1158/1535-7163.mct-22-0415
https://doi.org/10.1158/1535-7163.mct-22-0415
Autor:
Joan Jacob, Liezl E. Francisco, Treena Chatterjee, Zhengdong Liang, Shraddha Subramanian, Qingyun J. Liu, Julie H. Rowe, Kendra S. Carmon
Publikováno v:
British Journal of Cancer. 128:1592-1602
Antibody-drug conjugates (ADCs) have become an increasingly successful class of anticancer therapy, particularly within the past few years. Though ADCs are in clinical trials for colorectal cancer (CRC), a candidate has yet to be approved. CRC contin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c31f42f7ee8312cf625cca3bc318d77
https://doi.org/10.1038/s41416-023-02192-3
https://doi.org/10.1038/s41416-023-02192-3
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
shows effects of chemotherapies and ADC on LGR5 protein and mRNA expression and LGR5 knockdown effects on clonogenicity, signaling pathways, and expression of STAT3 target genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b57b8002ac79aa5e68de778851d7158
https://doi.org/10.1158/1535-7163.22758737
https://doi.org/10.1158/1535-7163.22758737
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
shows cytotoxicity of inhibitors of MET, STAT3, and Wnt in CTL and LGR5 KD/KO CRC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a223c1b020177500b361067c9bd9fa
https://doi.org/10.1158/1535-7163.22758731.v1
https://doi.org/10.1158/1535-7163.22758731.v1
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
Table S1 shows IC50 values for irinotecan and anti-LGR5 ADCs in CRC cells with overexpression of STAT3-CA or LGR5; Table S2 shows IC50 values for MET and STAT3 inhibitors in CRC cells with and without loss of LGR5 expression; Table S3 shows combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4cc74ecd71c2cb5036355c5aefd9fc
https://doi.org/10.1158/1535-7163.22758719
https://doi.org/10.1158/1535-7163.22758719
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
shows LGR5 expression and cytotoxicity of irinotecan, stattic, and anti-LGR5 ADCs in PDO model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b466ba827a5d0d5a17996f3eb002bb9
https://doi.org/10.1158/1535-7163.22674492
https://doi.org/10.1158/1535-7163.22674492
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
Leucine-rich repeat-containing, G protein-coupled receptor 5 (LGR5) is highly expressed in colorectal cancer and cancer stem cells (CSCs) that play important roles in tumor initiation, progression, and metastasis. Loss of LGR5 has been shown to enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f983fff72c69bfaaac1b2d28e898dd5d
https://doi.org/10.1158/1535-7163.c.6611316.v1
https://doi.org/10.1158/1535-7163.c.6611316.v1
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
shows inhibitors of IL6/Gp130 and EGFR do not attenuate STAT3 activation in LGR5 KD/KO CRC cells, LGR5 KD in DLD-1 cells increases MET-STAT3 activation, and the effects of MET and STAT3 inhibitors at different time-points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3240cae0308bc290a3fc7c9cbb0aa6d6
https://doi.org/10.1158/1535-7163.22674501.v1
https://doi.org/10.1158/1535-7163.22674501.v1
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
shows effects of combination treatment on antitumor efficacy and survival in LoVo LGR5 KD xenografts and body weights of xenografts during treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a38ce728d9ecde561a4d3693dbcb2c6
https://doi.org/10.1158/1535-7163.22674489
https://doi.org/10.1158/1535-7163.22674489
Autor:
Kendra S. Carmon, Zhengdong Liang, Liezl E. Francisco, Shraddha Subramanian, Ashlyn Parkhurst, Joan Jacob, Tressie A. Posey
shows cytotoxicity of cryptotanshinone in combination with irinotecan in control and LGR5 KD LoVo cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb9da904153496b7f67ea51436255f8
https://doi.org/10.1158/1535-7163.22674495
https://doi.org/10.1158/1535-7163.22674495