Delayed and Attenuated Antibody Responses to Coronavirus Disease 2019 Vaccination With Poor Cross-Variant Neutralization in Solid-Organ Transplant Recipients—A Prospective Longitudinal Study.

Autor: Liew, May Y¹ (AUTHOR), Mathews, Josh I¹ (AUTHOR), Li, Amy² (AUTHOR), Singh, Rohan¹ (AUTHOR), Jaramillo, Salvador A¹ (AUTHOR), Weiss, Zoe F¹ (AUTHOR), Bowman, Kathryn¹ (AUTHOR), Ankomah, Pierre O¹ (AUTHOR), Ghantous, Fadi³ (AUTHOR), Lewis, Gregory D^4,5 (AUTHOR), Neuringer, Isabel⁶ (AUTHOR), Bitar, Natasha¹ (AUTHOR), Lipiner, Taryn¹ (AUTHOR), Dighe, Anand S⁷ (AUTHOR), Kotton, Camille N¹ (AUTHOR), Seaman, Michael S^3,5 (AUTHOR), Lemieux, Jacob E^1,5,8,9 (AUTHOR) jelemieux@partners.org, Goldberg, Marcia B^1,5,8,9 (AUTHOR) jelemieux@partners.org

Publikováno v: Open Forum Infectious Diseases. Aug2023, Vol. 10 Issue 8, p1-10. 10p.

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Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).

Autor: Boucau, Julie, Uddin, Rockib, Marino, Caitlin, Regan, James, Flynn, James P, Choudhary, Manish C, Chen, Geoffrey, Stuckwisch, Ashley M, Mathews, Josh, Liew, May Y, Singh, Arshdeep, Reynolds, Zahra, Iyer, Surabhi L, Chamberlin, Grace C, Vyas, Tammy D, Vyas, Jatin M, Turbett, Sarah E, Li, Jonathan Z, Lemieux, Jacob E, Barczak, Amy K

Publikováno v: Clinical Infectious Diseases; 2/1/2023, Vol. 76 Issue 3, pe526-e529, 4p

Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance.

Autor: Phan T; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87544, USA., Ribeiro RM; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87544, USA., Edelstein GE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Boucau J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Uddin R; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Marino C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Liew MY; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Barry M; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Choudhary MC; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Tien D; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Su K; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Reynolds Z; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Li Y; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA.; University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA., Sagar S; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Vyas TD; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Kawano Y; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Sparks JA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Hammond SP; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Wallace Z; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Vyas JM; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Li JZ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Siedner MJ; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA.; Africa Health Research Institute, KwaZulu-Natal, South Africa., Barczak AK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA., Lemieux JE; Department of Medicine, Massachusetts General Hospital, Havard Medical School, Boston, MA 02114, USA.; Broad Institute, Cambridge, MA 02142, USA., Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.; Santa Fe Institute, Santa Fe, NM 87501, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.

Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses.

Autor: Seaman MS; Beth Israel Deaconess Medical Center, Boston, MA.; Harvard Medical School, Boston, MA., Siedner MJ; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA., Boucau J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA., Lavine CL; Beth Israel Deaconess Medical Center, Boston, MA., Ghantous F; Beth Israel Deaconess Medical Center, Boston, MA., Liew MY; Massachusetts General Hospital, Boston, MA, USA., Mathews J; Massachusetts General Hospital, Boston, MA, USA., Singh A; Massachusetts General Hospital, Boston, MA, USA., Marino C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Regan J; Brigham and Women's Hospital Boston, MA, USA., Uddin R; Massachusetts General Hospital, Boston, MA, USA., Choudhary MC; Brigham and Women's Hospital Boston, MA, USA., Flynn JP; Brigham and Women's Hospital Boston, MA, USA., Chen G; Massachusetts General Hospital, Boston, MA, USA., Stuckwisch AM; Massachusetts General Hospital, Boston, MA, USA., Lipiner T; Massachusetts General Hospital, Boston, MA, USA., Kittilson A; Brigham and Women's Hospital Boston, MA, USA., Melberg M; Brigham and Women's Hospital Boston, MA, USA., Gilbert RF; Massachusetts General Hospital, Boston, MA, USA., Reynolds Z; Massachusetts General Hospital, Boston, MA, USA., Iyer SL; Massachusetts General Hospital, Boston, MA, USA., Chamberlin GC; Massachusetts General Hospital, Boston, MA, USA., Vyas TD; Massachusetts General Hospital, Boston, MA, USA., Vyas JM; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA., Goldberg MB; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA., Luban J; UMass Med School, Worcester, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Broad Institute, Cambridge, MA, USA., Li JZ; Brigham and Women's Hospital Boston, MA, USA., Barczak AK; Massachusetts General Hospital, Boston, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Lemieux JE; Harvard Medical School, Boston, MA.; Massachusetts General Hospital, Boston, MA, USA.; Broad Institute, Cambridge, MA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2022 Mar 03. Date of Electronic Publication: 2022 Mar 03.