Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Lieve Naesens"'
Autor:
Laura Seldeslachts, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Jeason Haughton, Teresa Prezzemolo, Oliver Burton, Simon Feys, Frank L. van de Veerdonk, Agostinho Carvalho, Lieve Naesens, Patrick Matthys, Katrien Lagrou, Erik Verbeken, Georgios Chamilos, Joost Wauters, Stephanie Humblet-Baron, Greetje Vande Velde
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105347- (2024)
Summary: Background: Influenza-associated pulmonary aspergillosis (IAPA) is a severe fungal superinfection in critically ill influenza patients that is of incompletely understood pathogenesis. Despite the use of contemporary therapies with antifungal
Externí odkaz:
https://doaj.org/article/f1c0a658976b449e99040d50fd414abc
Autor:
Ali Pormohammad, Melika Moradi, Josefien W. Hommes, Eugènia Pujol, Lieve Naesens, Santiago Vázquez, Bas G. J. Surewaard, Mohammad Zarei, Manuel Vazquez-Carrera, Raymond J. Turner
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Novel antimicrobial agents are needed to combat antimicrobial resistance. This study tested novel pentafluorosulfanyl-containing triclocarban analogs for their potential antibacterial efficacy. Standard procedures were used to produce pentaf
Externí odkaz:
https://doaj.org/article/a8d67d93cda24ba49779369483d1e709
Autor:
Ilona Bereczki, Vladimir Vimberg, Eszter Lőrincz, Henrietta Papp, Lajos Nagy, Sándor Kéki, Gyula Batta, Ana Mitrović, Janko Kos, Áron Zsigmond, István Hajdú, Zsolt Lőrincz, Dávid Bajusz, László Petri, Jan Hodek, Ferenc Jakab, György M. Keserű, Jan Weber, Lieve Naesens, Pál Herczegh, Anikó Borbás
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Patients infected with SARS-CoV-2 risk co-infection with Gram-positive bacteria, which severely affects their prognosis. Antimicrobial drugs with dual antiviral and antibacterial activity would be very useful in this setting. Although glycop
Externí odkaz:
https://doaj.org/article/91f0f017bd784a0087174f5750d3561a
Autor:
Eszter Boglárka Lőrincz, Mihály Herczeg, Josef Houser, Martina Rievajová, Ákos Kuki, Lenka Malinovská, Lieve Naesens, Michaela Wimmerová, Anikó Borbás, Pál Herczegh, Ilona Bereczki
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17268 (2023)
In the shadow of SARS-CoV-2, influenza seems to be an innocent virus, although new zoonotic influenza viruses evolved by mutations may lead to severe pandemics. According to WHO, there is an urgent need for better antiviral drugs. Blocking viral hema
Externí odkaz:
https://doaj.org/article/ab384dde763d4113b4a3247c043b338d
Autor:
Laura Seldeslachts, Lore Vanderbeke, Astrid Fremau, Agustin Reséndiz-Sharpe, Cato Jacobs, Bo Laeveren, Tessa Ostyn, Lieve Naesens, Matthias Brock, Frank L. Van De Veerdonk, Stephanie Humblet-Baron, Erik Verbeken, Katrien Lagrou, Joost Wauters, Greetje Vande Velde
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 2493-2508 (2021)
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immunocompetent
Externí odkaz:
https://doaj.org/article/1a58bca21f2048878a27c71e670ede56
Autor:
Annelies Stevaert, Ria Van Berwaer, Cato Mestdagh, Julie Vandeput, Els Vanstreels, Valerie Raeymaekers, Manon Laporte, Lieve Naesens
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urges better understanding of the functional motifs in the spike (S) protein and their tolerance to mutations. Here, we focused on the S
Externí odkaz:
https://doaj.org/article/c9eb7daf134d4d728bceb84fb8af5508
Autor:
Kelly Bugatti, Andrea Sartori, Lucia Battistini, Crescenzo Coppa, Emiel Vanhulle, Sam Noppen, Becky Provinciael, Lieve Naesens, Annelies Stevaert, Alessandro Contini, Kurt Vermeire, Franca Zanardi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8765 (2023)
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safe anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike (S) protein of SARS-CoV-
Externí odkaz:
https://doaj.org/article/f60413dfa7c94c51ab033a9e6be82aaf
Autor:
Miklós Bege, Alexandra Kiss, Ilona Bereczki, Jan Hodek, Lenke Polyák, Gábor Szemán-Nagy, Lieve Naesens, Jan Weber, Anikó Borbás
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12566 (2022)
d-Arabinofuranosyl-pyrimidine and -purine nucleoside analogues containing alkylthio-, acetylthio- or 1-thiosugar substituents at the C2’ position were prepared from the corresponding 3’,5’-O-silylene acetal-protected nucleoside 2’-exomethylen
Externí odkaz:
https://doaj.org/article/4e31e1fe77574c7ba4f71155525b74e2
Autor:
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1021 (2022)
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–ac
Externí odkaz:
https://doaj.org/article/d301b0071e384bba936c2d8ac80db4e5
Autor:
Manon Laporte, Valerie Raeymaekers, Ria Van Berwaer, Julie Vandeput, Isabel Marchand-Casas, Hendrik-Jan Thibaut, Dominique Van Looveren, Katleen Martens, Markus Hoffmann, Piet Maes, Stefan Pöhlmann, Lieve Naesens, Annelies Stevaert
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009500 (2021)
The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper airways, which is not observed for the other highly pathogenic coronaviruses SARS-CoV and MERS-CoV. We here reveal features of the coronavirus spike (S) protein,
Externí odkaz:
https://doaj.org/article/2bc3d90380d249a3aa02f9334a1946a2