Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy

Autor: Woutje M. Berdowski, Herma C. van der Linde, Marjolein Breur, Nynke Oosterhof, Shanice Beerepoot, Leslie Sanderson, Lieve I. Wijnands, Patrick de Jong, Elisa Tsai-Meu-Chong, Walter de Valk, Moniek de Witte, Wilfred F. J. van IJcken, Jeroen Demmers, Marjo S. van der Knaap, Marianna Bugiani, Nicole I. Wolf, Tjakko J. van Ham

Publikováno v: Acta Neuropathologica 144 (2022) 2
Acta Neuropathologica, 144(2), 211-239. Springer Verlag
Acta Neuropathologica, 144, 211-239. SPRINGER
Acta Neuropathologica, 144(2), 211-239. Springer-Verlag
Berdowski, W M, van der Linde, H C, Breur, M, Oosterhof, N, Beerepoot, S, Sanderson, L, Wijnands, L I, de Jong, P, Tsai-Meu-Chong, E, de Valk, W, de Witte, M, van IJcken, W F J, Demmers, J, van der Knaap, M S, Bugiani, M, Wolf, N I & van Ham, T J 2022, ' Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy ', Acta Neuropathologica, vol. 144, no. 2, pp. 211-239 . https://doi.org/10.1007/s00401-022-02440-5
Acta Neuropathologica, 144(2), 211-239

Tissue-resident macrophages of the brain, including microglia, are implicated in the pathogenesis of various CNS disorders and are possible therapeutic targets by their chemical depletion or replenishment by hematopoietic stem cell therapy. Neverthel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddadef2bdc7da915da1bb7314cdad89f
https://doi.org/10.1007/s00401-022-02440-5