Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Lieve, Verlinden"'
Autor:
Stefanie Doms, Lieve Verlinden, Iris Janssens, Justine Vanhevel, Roy Eerlings, René Houtman, Shigeaki Kato, Chantal Mathieu, Brigitte Decallonne, Geert Carmeliet, Annemieke Verstuyf
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract The vitamin D receptor (VDR) plays a critical role in the regulation of mineral and bone homeostasis. Upon binding of 1α,25-dihydroxyvitamin D3 to the VDR, the activation function 2 (AF2) domain repositions and recruits coactivators for the
Externí odkaz:
https://doaj.org/article/f27a6b6d0cb449ae93888a4d081135ad
Autor:
Sergi Llambrich, Birger Tielemans, Ellen Saliën, Marta Atzori, Kaat Wouters, Vicky Van Bulck, Mark Platt, Laure Vanherp, Nuria Gallego Fernandez, Laura Grau de la Fuente, Harish Poptani, Lieve Verlinden, Uwe Himmelreich, Anca Croitor, Catia Attanasio, Zsuzsanna Callaerts-Vegh, Willy Gsell, Neus Martínez-Abadías, Greetje Vande Velde
Publikováno v:
eLife, Vol 12 (2024)
Down syndrome (DS) is characterized by skeletal and brain structural malformations, cognitive impairment, altered hippocampal metabolite concentration and gene expression imbalance. These alterations were usually investigated separately, and the pote
Externí odkaz:
https://doaj.org/article/d1bf3adbb5e949bbaf5fbc9292d9e0ff
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionDue to the relatively long life span of rodent models, in order to expediate the identification of novel therapeutics of age related diseases, mouse models of accelerated aging have been developed. In this study we examined skeletal chang
Externí odkaz:
https://doaj.org/article/ec71a6aba2cc46458b1bcd6c26a7a449
Autor:
Lieve Verlinden, Stefanie Doms, Iris Janssens, Mark B. Meyer, J. Wesley Pike, Geert Carmeliet, Annemieke Verstuyf
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionNeuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover, NRP2 expression is suggested to be involved in the regulation of bone
Externí odkaz:
https://doaj.org/article/ebe7e524e4a4478983c68aea0c4b42f5
Autor:
Jef Serré, Carolien Mathyssen, Tom Tanjeko Ajime, Tobias Heigl, Lieve Verlinden, Karen Maes, Annemieke Verstuyf, Didier Cataldo, Jeroen Vanoirbeek, Bart Vanaudenaerde, Wim Janssens, Ghislaine Gayan-Ramirez
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients. However, oral vitamin D supplementation is limite
Externí odkaz:
https://doaj.org/article/8de62b396ca648018017f65abd30c61c
Autor:
Justine Vanhevel, Lieve Verlinden, Shauni Loopmans, Stefanie Doms, Iris Janssens, Sien Bevers, Steve Stegen, Hans Wildiers, Annemieke Verstuyf
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Active vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], and its synthetically derived analogs possess potent anticancer properties. In breast cancer (BC) cells, 1,25(OH)2D3 blocks cell proliferation and induces apoptosis through different cell-typ
Externí odkaz:
https://doaj.org/article/f8c2d50d3b314c8eb21cb7d3f7fb7c48
Autor:
Catarina Meng, Hanne Skou Jørgensen, Lieve Verlinden, Nathalie Bravenboer, Henriette de Loor, Patrick C. D'Haese, Geert Carmeliet, Pieter Evenepoel
Publikováno v:
Bone Reports, Vol 16, Iss , Pp 101172- (2022)
Bone microarchitecture is an important component of bone quality and disturbances may reduce bone strength and resistance to trauma. Kidney transplant recipients have an excess risk of fractures, and bone loss affecting both trabecular and cortical b
Externí odkaz:
https://doaj.org/article/60f320836ea749d299c5a1a3190b0dc1
Autor:
Pieter-Jan Martens, Javier Centelles-Lodeiro, Darcy Ellis, Dana Paulina Cook, Gabriele Sassi, Lieve Verlinden, Annemieke Verstuyf, Jeroen Raes, Chantal Mathieu, Conny Gysemans
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The hormonally-active form of vitamin D, 1,25-dihydroxyvitamin D3, can modulate both innate and adaptive immunity, through binding to the nuclear vitamin D receptor expressed in most immune cells. A high dose of regular vitamin D protected non-obese
Externí odkaz:
https://doaj.org/article/7e7cfecdd2334f6f8b7b29d02f511920
Autor:
Lieve Verlinden, Geert Carmeliet
Publikováno v:
JBMR Plus, Vol 5, Iss 12, Pp n/a-n/a (2021)
ABSTRACT 1,25(OH)2D3, the biologically active form of vitamin D3, is a major regulator of mineral and bone homeostasis and exerts its actions through binding to the vitamin D receptor (VDR), a ligand‐activated transcription factor that can directly
Externí odkaz:
https://doaj.org/article/cbb7715aa48b48efbdb9716556a501cf
Autor:
Anna Y. Belorusova, Daniela Rovito, Yassmine Chebaro, Stefanie Doms, Lieve Verlinden, Annemieke Verstuyf, Daniel Metzger, Natacha Rochel, Gilles Laverny
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8445 (2022)
The Vitamin D receptor (VDR) plays a key role in calcium homeostasis, as well as in cell proliferation and differentiation. Among the large number of VDR ligands that have been developed, we have previously shown that BXL-62 and Gemini-72, two C-20-m
Externí odkaz:
https://doaj.org/article/5252e406bde940ce937811cf1cef9b09