Culture density influences the functional phenotype of human macrophages

Autor: Adele V. Ruder, Lieve Temmerman, Joep M.A. van Dommelen, Jan Nagenborg, Chang Lu, Judith C. Sluimer, Pieter Goossens, Erik A.L. Biessen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Macrophages (MΦ) are commonly cultured in vitro as a model of their biology and functions in tissues. Recent evidence suggests MΦ to engage in quorum sensing, adapting their functions in response to cues about the proximity of neighboring cells. Ho

Externí odkaz: https://doaj.org/article/47b579081a8041bf973af134d1fc3d2b

Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth

Autor: Emil Chteinberg, Suzan Wetzels, Wouter Gerritsen, Lieve Temmerman, Joost van den Oord, Erik Biessen, Anna Kordelia Kurz, Véronique Winnepenninckx, Martin Zenke, Ernst-Jan Speel, Axel zur Hausen

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 12 (2020)

Background: Merkel cell carcinoma (MCC) is a highly malignant skin cancer. Despite major treatment improvements during the last decade, up to 50% of patients do not respond to therapy or develop recurrent disease. For these patients, alternative trea

Externí odkaz: https://doaj.org/article/b16ae6b01d8a4a70ac0deccedf5a266c

A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

Autor: Renée J. H. A. Tillie, Thomas L. Theelen, Kim van Kuijk, Lieve Temmerman, Jenny de Bruijn, Marion Gijbels, Christer Betsholtz, Erik A. L. Biessen, Judith C. Sluimer

Publikováno v: Cells, Vol 10, Iss 7, p 1746 (2021)

Platelet-derived growth factor B (PDGF-B) is a mitogenic, migratory and survival factor. Cell-associated PDGF-B recruits stabilizing pericytes towards blood vessels through retention in extracellular matrix. We hypothesized that the genetic ablation

Externí odkaz: https://doaj.org/article/0540925b8de148c6998a61bf041b8371

Monocyte Heterogeneity in Cardiovascular Disease

Autor: Adele V Ruder, Suzan M W Wetzels, Lieve Temmerman, Erik A L Biessen, Pieter Goossens

Publikováno v: Cardiovascular Research.

Monocytes circulate the vasculature at steady state and are recruited to sites of inflammation where they differentiate into macrophages (MФ) to replenish tissue-resident MФ populations and engage in the development of cardiovascular disease (CVD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed0a045310af6e791d67403339c1d73e
https://doi.org/10.1093/cvr/cvad069

Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol

Autor: Kim van Kuijk, Ian R McCracken, Renée J H A Tillie, Sebastiaan E J Asselberghs, Dlzar A Kheder, Stan Muitjens, Han Jin, Richard S Taylor, Ruud Wichers Schreur, Christoph Kuppe, Ross Dobie, Prakesh Ramachandran, Marion J Gijbels, Lieve Temmerman, Phoebe M Kirkwoord, Joris Luyten, Yanming Li, Heidi Noels, Pieter Goossens, John R Wilson-Kanamori, Leon J Schurgers, Ying H Shen, Barend M E Mees, Erik A L Biessen, Neil C Henderson, Rafael Kramann, Andrew H Baker, Judith C Sluimer

Publikováno v: van Kuijk, K, McCracken, I, Tillie, RJHA, Asselberghs, SEJ, Kheder, DA, Muitjens, S, Jin, H, Taylor, R S, Wichers Schreur, R, Kuppe, C, Dobie, R, Ramachandran, P, Gijbels, M J, Temmerman, L, Kirkwoord, PM, Luyten, J, Li, Y, Noels, H, Goossens, P, Wilson-Kanamori, J R, Schurgers, L J, Shen, YH, Mees, BME, Biessen, E A L, Henderson, N C, Kramann, R, Baker, A H & Sluimer, J 2023, ' Human and murine fibroblast single cell transcriptomics reveals fibroblast clusters are differentially affected by ageing, and serum cholesterol ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvad016

Aims Specific fibroblast markers and in-depth heterogeneity analysis are currently lacking, hindering functional studies in cardiovascular diseases (CVDs). Here, we established cell-type markers and heterogeneity in murine and human arteries and stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4284963a76fbdd9b58b41521f19806b5
https://doi.org/10.1093/cvr/cvad016