Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.

Autor: Simpson JB; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Walker ME; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Sekela JJ; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Ivey SM; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Jariwala PB; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Storch CM; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Kowalewski ME; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA., Graboski AL; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA., Lietzan AD; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Walton WG; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Davis KA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA., Cloer EW; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Borlandelli V; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Hsiao YC; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Roberts LR; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Perlman DH; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Liang X; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Overkleeft HS; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Bhatt AP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lu K; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Redinbo MR; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA. Electronic address: redinbo@unc.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 Jun 12; Vol. 32 (6), pp. 925-944.e10. Date of Electronic Publication: 2024 May 15.

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.

Autor: Carlson DL; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Kowalewski M; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, 3(rd) Floor, Genetic Medicine Building, Chapel Hill, NC 27599, USA., Bodoor K; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Lietzan AD; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, The University of North Carolina at Chapel Hill, 385 South Columbia Street, Chapel Hill, NC 27599, USA., Hughes PF; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Gooden D; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Loiselle DR; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Alcorta D; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Dingman Z; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Mueller EA; Sarafan ChEM-H Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA., Irnov I; Sarafan ChEM-H Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA., Modla S; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA., Chaya T; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA., Caplan J; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA., Embers M; Department of Microbiology and Immunology, 18703 Three Rivers Road, Covington, LA 70433, USA., Miller JC; Galaxy Diagnostics, Inc, P.O. Box 14346 7020 Kit Creek Road, Ste 130, Research Triangle Park, Raliegh, NC 27709, USA., Jacobs-Wagner C; Sarafan ChEM-H Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA; Biology Department, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA; Howard Hughes Medical Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA., Redinbo MR; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, 3(rd) Floor, Genetic Medicine Building, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina at Chapel Hill, 4350 Genome Sciences Building, 250 Bell Tower Drive, Chapel Hill, NC 27599-3290, USA. Electronic address: redinbo@unc.edu., Spector N; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Haystead TAJ; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA. Electronic address: timothy.haystead@duke.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Mar 21; Vol. 31 (3), pp. 465-476.e12. Date of Electronic Publication: 2023 Nov 01.

Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome.

Autor: Conway JM; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA., Walton WG; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Salas-González I; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Law TF; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lindberg CA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Crook LE; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kosina SM; Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Fitzpatrick CR; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lietzan AD; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Northen TR; Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Jones CD; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Finkel OM; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Plant and Environmental Sciences, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Redinbo MR; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. redinbo@unc.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. redinbo@unc.edu.; Department of Biochemistry and Biophysics, and the Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. redinbo@unc.edu.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. redinbo@unc.edu., Dangl JL; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dangl@email.unc.edu.; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dangl@email.unc.edu.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dangl@email.unc.edu.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dangl@email.unc.edu.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dangl@email.unc.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2022 Nov; Vol. 7 (11), pp. 1817-1833. Date of Electronic Publication: 2022 Oct 20.

The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase.

Autor: Lietzan AD; Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA., Lin Y; Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA., St Maurice M; Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA. Electronic address: martin.stmaurice@marquette.edu.

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2014 Nov 15; Vol. 562, pp. 70-9. Date of Electronic Publication: 2014 Aug 23.

Functionally diverse biotin-dependent enzymes with oxaloacetate decarboxylase activity.

Autor: Lietzan AD; Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA., St Maurice M; Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA. Electronic address: martin.stmaurice@marquette.edu.

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2014 Feb 15; Vol. 544, pp. 75-86. Date of Electronic Publication: 2013 Oct 30.