Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Liette Belair"'
Autor:
Zheng Huang, Lei Zhang, Liette Belair, Wayne Sturkenboom, Chun Sing Li, Yeeman K. Ramtohul, Jocelyne Guay, Renata Murgasva
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5214-5217
SCD1 inhibition may represent a novel treatment for obesity, type-2 diabetes and related metabolic disorders. A prototype thiazole amide analog 13 (MF-152) was identified as an excellent tool in the study of SCD biology in animals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348930203ee59f6b0f5762c823d46d85
https://doi.org/10.1016/j.bmcl.2009.07.015
https://doi.org/10.1016/j.bmcl.2009.07.015
Autor:
Renata M. Oballa, Liette Belair, W. Cameron Black, Kelly Bleasby, Chi Chung Chan, Carole Desroches, Xiaobing Du, Robert Gordon, Jocelyne Guay, Sebastien Guiral, Michael J. Hafey, Emelie Hamelin, Zheng Huang, Brian Kennedy, Nicolas Lachance, France Landry, Chun Sing Li, Joseph Mancini, Denis Normandin, Alessandro Pocai, David A. Powell, Yeeman K. Ramtohul, Kathryn Skorey, Dan Sørensen, Wayne Sturkenboom, Angela Styhler, Deena M. Waddleton, Hao Wang, Simon Wong, Lijing Xu, Lei Zhang
Publikováno v:
Journal of medicinal chemistry. 54(14)
The potential use of SCD inhibitors for the chronic treatment of diabetes and dyslipidemia has been limited by preclinical adverse events associated with inhibition of SCD in skin and eye tissues. To establish a therapeutic window, we embarked on des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c43863779b7e91be0da9e7afe20903
https://pubmed.ncbi.nlm.nih.gov/21661758
https://pubmed.ncbi.nlm.nih.gov/21661758