Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Liesl G. Fisher"'
Autor:
Liesl G. Fisher, P.J. McCann, D.A. Young, C.M. Arbeeny, S. Skwish, Amarendra B. Mikkilineni, Poss Kathleen M, G.T. Allen, Chongqing Sun, Michael Cap, R.J. George, Dorothy Slusarchyk, B.E. Abboa-Offei, Ravindar N. Girotra, William N. Washburn, Carl P. Ciosek, A.V. Gavai, Belay Tesfamariam, T.W. Harper, Ginger Wu, B.H. Frohlich, D.E. Hillyer, Tammy C. Wang, A A Seymour, Mark S. Bednarz, Philip M. Sher, Kenneth E.J. Dickinson, T.L. Waldron, Arvind Mathur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3041-3044
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist (K(i)=
Autor:
Philip M. Sher, Liesl G. Fisher, Steven M. Seiler, Inge M. Michel, S. Skwish, Gang Wu, Arvind Mathur, Kenneth E.J. Dickinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1583-1588
Carboxyl and other negatively charged groups were found to be most effective at producing human β3 adrenergic receptor binding selectivity in 1 (BRL 37344) and related compounds. The sulfonic acid analog 7 (BMS-187413) is a novel and potent β3 adre
Autor:
Liesl G. Fisher, Kenneth E.J. Dickinson, Inge M. Michel, S. Skwish, Steven M. Seiler, Philip M. Sher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2253-2258
Novel heterocyclic β 3 adrenergic receptor agonists 2 were prepared and evaluated for their ability to bind to human β 1 , β 2 , and β 3 adrenergic receptors. Stimulatory effects on the β 3 adrenergic receptor were also measured. BMS-187257 ( 4b
Autor:
Inge M. Michel, S. Skwish, Steven M. Seiler, Liesl G. Fisher, Kenneth E.J. Dickinson, Philip M. Sher
Publikováno v:
ChemInform. 28
Novel heterocyclic β 3 adrenergic receptor agonists 2 were prepared and evaluated for their ability to bind to human β 1 , β 2 , and β 3 adrenergic receptors. Stimulatory effects on the β 3 adrenergic receptor were also measured. BMS-187257 ( 4b