Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Liesl A. Lawrence"'
Publikováno v:
Clinical Cancer Research. 28:A012-A012
The goals of this study are to investigate how EWS-FLI1 disrupts regulation of transcription and splicing in Ewing sarcoma, and to evaluate this dysregulation as a potential therapeutic target. Ewing Sarcoma is an aggressive pediatric bone and soft t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b4dec1a805da5d925236361f974c4e
https://doi.org/10.1158/1557-3265.sarcomas22-a012
https://doi.org/10.1158/1557-3265.sarcomas22-a012
Autor:
Nicklas Bassani, Henry E. Miller, Liesl A. Lawrence, Aparna Gorthi, Alexander J.R. Bishop, Brian S. Iskra
Publikováno v:
Cancers
Volume 12
Issue 4
Cancers, Vol 12, Iss 948, p 948 (2020)
Volume 12
Issue 4
Cancers, Vol 12, Iss 948, p 948 (2020)
Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11
22) (q24
q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Co
22) (q24
q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4010caeb66aca33d55e46e23787784eb
Publikováno v:
Cancer Research. 80:B24-B24
Ewing sarcoma (EwS) is a pediatric and young adult cancer that is driven by the EWSR1-FLI1 translocation. Despite decades of work, this cancer is still an enigma, with poorly understood biology and no targeted treatments. Our recent work published in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65442bf96e6129e24e0cb5566ca45966
https://doi.org/10.1158/1538-7445.pedca19-b24
https://doi.org/10.1158/1538-7445.pedca19-b24
Autor:
Xavier Bernard, Jeffrey A. Toretsky, Alexander J.R. Bishop, Elizabeth R. Lawlor, V. Pragathi Masamsetti, Lin Cao, Sydney Roston, Eva Loranc, Stephen L. Lessnick, Aparna Gorthi, Elicia Goodale, Kimberly Stegmaier, Amanda Balboni Iniguez, July Carolina Romero, Yi Chen, Liesl A. Lawrence
Publikováno v:
Nature. 559:E11-E11
Ewing sarcoma is an aggressive paediatric cancer of the bone and soft tissue. It results from a chromosomal translocation, predominantly t(11;22)(q24:q12), that fuses the N-terminal transactivation domain of the constitutively expressed EWSR1 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d212243eb20b75ff54b6bdcff73370
https://doi.org/10.1038/s41586-018-0230-z
https://doi.org/10.1038/s41586-018-0230-z
Autor:
Lin Cao, Kimberly Stegmaier, V. Pragathi Masamsetti, Liesl A. Lawrence, Elicia Goodale, Xavier Bernard, Eva Loranc, July Carolina Romero, Amanda Balboni Iniguez, Jeffrey A. Toretsky, Yi Chen, Alexander J.R. Bishop, Stephen L. Lessnick, Sydney Roston, Aparna Gorthi, Elizabeth R. Lawlor
Publikováno v:
Nature. 555(7696)
Ewing sarcoma is an aggressive paediatric cancer of the bone and soft tissue. It results from a chromosomal translocation, predominantly t(11;22)(q24:q12), that fuses the N-terminal transactivation domain of the constitutively expressed EWSR1 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7c947b0b9d3e8f7083ed0c744c5601
https://pubmed.ncbi.nlm.nih.gov/29950716
https://pubmed.ncbi.nlm.nih.gov/29950716