Axenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression

Autor: Huaihan Cai, Ping Wu, Lieselot Vandemeulebroucke, Ineke Dhondt, Madina Rasulova, Andy Vierstraete, Bart P. Braeckman

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 19, p 11517 (2022)

Axenically cultured C. elegans show many characteristic traits of worms subjected to dietary restriction, such as slowed development, reduced fertility, and increased stress resistance. Hence, the term axenic dietary restriction (ADR) is often applie

Externí odkaz: https://doaj.org/article/8a4f6666002d441aa05765f110baf76e

FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Autor: Ineke Dhondt, Vladislav A. Petyuk, Huaihan Cai, Lieselot Vandemeulebroucke, Andy Vierstraete, Richard D. Smith, Geert Depuydt, Bart P. Braeckman

Publikováno v: Cell Reports, Vol 16, Iss 11, Pp 3028-3040 (2016)

Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. However,

Externí odkaz: https://doaj.org/article/19b68d92d6af46d18ff4b9ec415b5c77

Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan

Autor: Aleksandra Zečić, Ineke Dhondt, Lieselot Vandemeulebroucke, Jose Manuel Monje Moreno, Madina Rasulova, Bart P. Braeckman

Publikováno v: Metabolites
Volume 11
Issue 2
METABOLITES
Metabolites, Vol 11, Iss 105, p 105 (2021)

The C. elegans insulin/IGF-1 (insulin-like growth factor 1) signaling mutant daf-2 recapitulates the dauer metabolic signature-a shift towards lipid and carbohydrate accumulation-which may be linked to its longevity and stress resistance phenotypes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563da851dbdca8f94364e6bede00abd7

CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans

Autor: Huaihan Cai, Caroline Vlaeminck, Madina Rasulova, Bart P. Braeckman, Lieselot Vandemeulebroucke, Ineke Dhondt

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

When cultured in axenic medium, Caenorhabditis elegans shows the largest life-span extension compared with other dietary restriction regimens. However, the underlying molecular mechanism still remains elusive. The gene cbp-1, encoding the worm orthol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81acc282a71d8d100505a0f332852859
https://pubmed.ncbi.nlm.nih.gov/29099917