Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Liesbeth, Spruijt"'
1
Akademický článek
TINF2 is a haploinsufficient tumor suppressor that limits telomere length
Autor: Isabelle Schmutz, Arjen R Mensenkamp, Kaori K Takai, Maaike Haadsma, Liesbeth Spruijt, Richarda M de Voer, Seunga Sara Choo, Franziska K Lorbeer, Emma J van Grinsven, Dirk Hockemeyer, Marjolijn CJ Jongmans, Titia de Lange
Publikováno v: eLife, Vol 9 (2020)
Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-pron
Externí odkaz: https://doaj.org/article/fefee7f4f78a4dcf9950c74585342521
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2
Akademický článek
Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility.
Autor: Richarda M de Voer, Marc-Manuel Hahn, Robbert D A Weren, Arjen R Mensenkamp, Christian Gilissen, Wendy A van Zelst-Stams, Liesbeth Spruijt, C Marleen Kets, Junxiao Zhang, Hanka Venselaar, Lilian Vreede, Nil Schubert, Marloes Tychon, Ronny Derks, Hans K Schackert, Ad Geurts van Kessel, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg, Roland P Kuiper
Publikováno v: PLoS Genetics, Vol 12, Iss 2, p e1005880 (2016)
Approximately 25-30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5-10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may b
Externí odkaz: https://doaj.org/article/d9f202028a73475093e7c1d60ba66471
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3
Evaluation of yield and experiences of age‐related molecular investigation for heritable and nonheritable causes of mismatch repair deficient colorectal cancer to identify Lynch syndrome
Autor: Janet R. Vos, Sera Langenveld, Liesbeth Spruijt, Ingrid E Fakkert, Edward M Leter, Marjolijn J. L. Ligtenberg, Arjen R. Mensenkamp, Riki W. Willems, Nicoline Hoogerbrugge, Iris D. Nagtegaal
Publikováno v: International Journal of Cancer
International Journal of Cancer, 147, 2150-2158
International Journal of Cancer, 147, 8, pp. 2150-2158
International Journal of Cancer, 147(8), 2150-2158. Wiley
Universal mismatch repair deficiency (dMMR) testing of colorectal cancer (CRC) is promoted as routine diagnostics to prescreen for Lynch syndrome. We evaluated the yield and experience of age‐related molecular investigation for heritable and nonher
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b685957977e871f78f34fcb5896bfd22
http://europepmc.org/articles/PMC7496272
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7
TINF2 is a haploinsufficient tumor suppressor that limits telomere length
Autor: Maaike Haadsma, Franziska K. Lorbeer, Marjolijn C.J. Jongmans, Seung-A Sara Choo, Richarda M. de Voer, Titia de Lange, Emma J van Grinsven, Dirk Hockemeyer, Kaori K. Takai, Isabelle Schmutz, Arjen R. Mensenkamp, Liesbeth Spruijt
Publikováno v: Elife, 9
eLife, Vol 9 (2020)
eLife
Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-pron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b2af333cf084d572afbabffd8e03eb
http://hdl.handle.net/2066/228576
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8
Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility
Autor: Encarna B. Gomez Garcia, Liesbeth Spruijt, Rolf H. Sijmons, Cora M. Aalfs, Margreet G. E. M. Ausems, Inga Bjørnevoll, Marjolijn J. L. Ligtenberg, Frederik J. Hes, Hans K. Schackert, Anna Jakubowska, Carla Oliveira, Rachel S. van der Post, Guglielmina Nadia Ranzani, Jan Lubinski, Annemieke Cats, Urszula Teodorczyk, Liselotte P. van Hest, Ingrid P. Vogelaar, Eveline J. Kamping, J. Han van Krieken, Maurizio Genuardi, Robbert D.A. Weren, Lizet E. van der Kolk, Elke Holinski-Feder, Anja Wagner, Nicoline Hoogerbrugge
Publikováno v: Journal of Medical Genetics, 55, 669-674
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Medical Genetics
Journal of Medical Genetics, 55(10), 669-674. BMJ Publishing Group
Weren, R D A, van der Post, R S, Vogelaar, I P, Han van Krieken, J, Spruijt, L, Lubinski, J, Jakubowska, A, Teodorczyk, U, Aalfs, C M, van Hest, L P, Oliveira, C, Kamping, E J, Schackert, H K, Ranzani, G N, García, E B G M, Hes, F J, Holinski-Feder, E, Genuardi, M, Ausems, M G E M, Sijmons, R H, Wagner, A, van der Kolk, L E, Cats, A, Bjørnevoll, I, Hoogerbrugge, N & Ligtenberg, M J L 2018, ' Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility ', Journal of Medical Genetics, vol. 55, no. 10, pp. 669-674 . https://doi.org/10.1136/jmedgenet-2017-104962
Journal of Medical Genetics, 55(10), 669-674
Journal of medical genetics, 55(10), 669-674. BMJ Publishing Group
Journal of Medical Genetics, 55, 10, pp. 669-674
BackgroundIn approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7affe88f414f3f722496f49bd18bff
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049163281&origin=inward
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9
Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing
Autor: Carla Oliveira, Roland P. Kuiper, Hildegunn Høberg-Vetti, James R. Lupski, Encarna B. Gomez Garcia, Margreet G. E. M. Ausems, Christian Gilissen, Liesbeth Spruijt, Elke Holinski-Feder, C. Marleen Kets, Urszula Teodorczyk, Jelle J. Goeman, Rachel S. van der Post, Ad Geurts van Kessel, Anja Wagner, Alexander Hoischen, Anna Jakubowska, Wendy A. G. van Zelst-Stams, Rolf H. Sijmons, Cora M. Aalfs, Nicoline Hoogerbrugge, Maartje van de Vorst, Marjolijn J. L. Ligtenberg, Maurizio Genuardi, Shalini N. Jhangiani, Jan Lubinski, Lisenka E.L.M. Vissers, Frederik J. Hes, Inga Bjørnevoll, J. Han van Krieken, Hugo Pinheiro, Hans K. Schackert, Joep de Ligt, Ingrid P. Vogelaar, Guglielmina Nadia Ranzani, Donna M. Muzny, Liselotte P. van Hest, Richard A. Gibbs, Lizet E. van der Kolk, Valeria Molinaro
Publikováno v: European Journal of Human Genetics, 25, 11, pp. 1246-1252
European Journal of Human Genetics, 25(11), 1246. Nature Publishing Group
European Journal of Human Genetics, 25(11), 1246-1252. Nature Publishing Group
European journal of human genetics, 25(11), 1246-1252. Nature Publishing Group
European Journal of Human Genetics, 25, 1246-1252
European Journal of Human Genetics
Vogelaar, I P, Van Der Post, R S, Van Krieken, J H J M, Spruijt, L, Van Zelst-Stams, W A G, Kets, C M, Lubinski, J, Jakubowska, A, Teodorczyk, U, Aalfs, C M, Van Hest, L P, Pinheiro, H, Oliveira, C, Jhangiani, S N, Muzny, D M, Gibbs, R A, Lupski, J R, De Ligt, J, Vissers, L E L M, Hoischen, A, Gilissen, C, Van De Vorst, M, Goeman, J J, Schackert, H K, Ranzani, G N, Molinaro, V, García, E B G, Hes, F J, Holinski-Feder, E, Genuardi, M, Ausems, M G E M, Sijmons, R H, Wagner, A, Van Der Kolk, L E, Bjørnevoll, I, Høberg-Vetti, H, Van Kessel, A G, Kuiper, R P, Ligtenberg, M J L & Hoogerbrugge, N 2017, ' Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing ', European Journal of Human Genetics, vol. 25, no. 11, pp. 1246-1252 . https://doi.org/10.1038/ejhg.2017.138
European Journal of Human Genetics, 25(11), 1246-1252
Contains fulltext : 182216.pdf (Publisher’s version ) (Open Access) Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric canc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8924302c8b22121fd84e066e6595ac39
https://doi.org/10.1038/ejhg.2017.138
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10
The apparent genetic anticipation in PMS2-associated Lynch syndrome families is explained by birth cohort effect
Autor: Stefan Aretz, Jenny von Salomé, Liesbeth Spruijt, Inge Bernstein, Tom G.W. Letteboer, Theo A. M. van Os, Kristina Lagerstedt-Robinson, Magnus von Knebel Doeberitz, Encarna B. Gomez-Garcia, Verena Steinke-Lange, Sanne W. ten Broeke, Maran J. W. Olderode-Berends, Hans K. Schackert, Marta Pineda, Manon Suerink, Gabriel Capellá, Nils Rahner, Carli M. J. Tops, Mar Rodríguez-Girondo, Christoph Engel, Anja Wagner, Pål Møller, Liselotte P. van Hest, Maartje Nielsen
Publikováno v: Ten Broeke, S W, Rodríguez-Girondo, M, Suerink, M, Aretz, S, Bernstein, I, Capella, G, Engel, C, Gomez-Garcia, E B, van Hest, L P, von Knebel Doeberitz, M, Lagerstedt-Robinson, K, Letteboer, T G W, Møller, P, van Os, T A M, Pineda, M, Rahner, N, Olderode-Berends, M J W, von Salomé, J, Schackert, H K, Spruijt, L, Steinke-Lange, V, Wagner, A, Tops, C M J & Nielsen, M 2019, ' The apparent genetic anticipation in PMS2-associated Lynch syndrome families is explained by birth cohort effect ', Cancer Epidemiology, Biomarkers & Prevention, vol. 28, no. 6, pp. 1010-1014 . https://doi.org/10.1158/1055-9965.EPI-18-0576
Cancer Epidemiology, Biomarkers & Prevention, 28, 6, pp. 1010-1014
Cancer Epidemiology, Biomarkers and Prevention, 28(6), 1010-1014
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 28(6), 1010-1014. AMER ASSOC CANCER RESEARCH
Cancer Epidemiology Biomarkers and Prevention, 28(6), 1010-1014. American Association for Cancer Research Inc.
Cancer Epidemiology Biomarkers & Prevention, 28(6), 1010-1014. American Association for Cancer Research Inc.
Cancer epidemiology, biomarkers & prevention, 28(6), 1010-1014. American Association for Cancer Research Inc.
Cancer Epidemiology, Biomarkers and Prevention, 28(6), 1010-1014. AMER ASSOC CANCER RESEARCH
Cancer Epidemiology, Biomarkers & Prevention, 28, 1010-1014
ten Broeke, S W, Rodríguez-Girondo, M, Suerink, M, Aretz, S, Bernstein, I, Capella, G, Engel, C, Gomez-Garcia, E B, van Hest, L P, von Knebel Doeberitz, M, Lagerstedt-Robinson, K, Letteboer, T G W, Moller, P, van Os, T A, Pineda, M, Rahner, N, Olderode-Berends, M J W, von Salome, J, Schackert, H K, Spruijt, L, Steinke-Lange, V, Wagner, A, Tops, C M J & Nielsen, M 2019, ' The apparent genetic anticipation in PMS2-associated lynch syndrome families is explained by birth-cohort effect ', Cancer Epidemiology Biomarkers and Prevention, vol. 28, no. 6, pp. 1010-1014 . https://doi.org/10.1158/1055-9965.EPI-18-0576
Background: PMS2-associated Lynch syndrome is characterized by a relatively low colorectal cancer penetrance compared with other Lynch syndromes. However, age at colorectal cancer diagnosis varies widely, and a strong genetic anticipation effect has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0beddab517e53f3ad2c205e858456c07
https://vbn.aau.dk/da/publications/40c915a4-1b63-4f9e-a656-f8d3d59aa08f
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