Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Liesbet Martens"'
Autor:
Irene Kleinberger, Ellen Sanders, Katrien Staes, Marleen Van Troys, Shinji Hirano, Tino Hochepied, Kelly Lemeire, Liesbet Martens, Christophe Ampe, Frans van Roy
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-33 (2022)
Abstract Background Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms differ
Externí odkaz:
https://doaj.org/article/f67b0e732ff24d6cb6c18854c8488483
Autor:
Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquière, Charlotte L. Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109748- (2021)
Summary: Obesity-induced inflammation is a major driving force in the development of insulin resistance, type 2 diabetes (T2D), and related metabolic disorders. During obesity, macrophages accumulate in the visceral adipose tissue, creating a low-gra
Externí odkaz:
https://doaj.org/article/8fd7d230be304c529b1a2ae294191f7d
Autor:
Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cel
Externí odkaz:
https://doaj.org/article/ddd72678135941fdb84362715749b1f1
Autor:
Bart Neyns, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg populatio
Externí odkaz:
https://doaj.org/article/f3b73327b159432399d5c58c01682dd6
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The increasing prevalence of obesity is accompanied by a rising incidence in metabolic syndrome and related pathologies such as non-alcoholic fatty liver disease. Macrophages are hypothesized to play central roles in these diseases, through their rol
Externí odkaz:
https://doaj.org/article/148d97539f88489fafb6d3f178d38ca4
Autor:
Aline Van Acker, Konrad Gronke, Aindrila Biswas, Liesbet Martens, Yvan Saeys, Jessica Filtjens, Sylvie Taveirne, Els Van Ammel, Tessa Kerre, Patrick Matthys, Tom Taghon, Bart Vandekerckhove, Jean Plum, Ildiko Rita Dunay, Andreas Diefenbach, Georges Leclercq
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1431-1443 (2017)
The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal Vγ3 T cells, intestinal intraepithelial CD8αα+ T lymphocytes, and CD49a+ liver natural killer (NK) cells. As the latter have recently been shown to
Externí odkaz:
https://doaj.org/article/6a4642d7f77f4b7b9316846659e527b8
Autor:
Katrien Van der Borght, Charlotte L. Scott, Veronika Nindl, Ann Bouché, Liesbet Martens, Dorine Sichien, Justine Van Moorleghem, Manon Vanheerswynghels, Sofie De Prijck, Yvan Saeys, Burkhard Ludewig, Thierry Gillebert, Martin Guilliams, Peter Carmeliet, Bart N. Lambrecht
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 3005-3017 (2017)
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An exa
Externí odkaz:
https://doaj.org/article/c4860be651284d9aa672697290287335
Autor:
Esther Hoste, Christian Maueröder, Lisette van Hove, Leen Catrysse, Hanna-Kaisa Vikkula, Mozes Sze, Bastiaan Maes, Dyah Karjosukarso, Liesbet Martens, Amanda Gonçalves, Eef Parthoens, Ria Roelandt, Wim Declercq, Ignacia Fuentes, Francis Palisson, Sergio Gonzalez, Julio C. Salas-Alanis, Louis Boon, Peter Huebener, Klaas Willem Mulder, Kodi Ravichandran, Yvan Saeys, Robert Felix Schwabe, Geert van Loo
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2689-2701.e4 (2019)
Summary: Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a danger-associated molecular pattern contributing to inflammatory pathologies. We show that HMGB1 derived from
Externí odkaz:
https://doaj.org/article/7a64937c6b7147c69bf52d9db0900e4f
Autor:
Hanne Dubois, Frederic Sorgeloos, Soroush T Sarvestani, Liesbet Martens, Yvan Saeys, Jason M Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007709 (2019)
Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenes
Externí odkaz:
https://doaj.org/article/a5e5350e08ed4b97b673e9f53edd4c1b
Autor:
Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin, Martin Guilliams
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their e
Externí odkaz:
https://doaj.org/article/fe465a1e14fb4c67be69745568b1a073